A5102788493- Advanced X-ray and CT Imaging
- Radiation Dose and Imaging
- Medical Imaging Techniques and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- MRI in cancer diagnosis
- Liver Disease and Transplantation
- Radiomics and Machine Learning in Medical Imaging
- Welding Techniques and Residual Stresses
- Appendicitis Diagnosis and Management
- Renal and Vascular Pathologies
- Radiology practices and education
- Advanced MRI Techniques and Applications
- Colorectal Cancer Screening and Detection
- Pancreatic and Hepatic Oncology Research
- Advanced Radiotherapy Techniques
- Renal cell carcinoma treatment
- Cardiac Imaging and Diagnostics
- Colorectal Cancer Surgical Treatments
- Genetic factors in colorectal cancer
- Gallbladder and Bile Duct Disorders
- Diverticular Disease and Complications
- Organ Transplantation Techniques and Outcomes
- Adrenal and Paraganglionic Tumors
- Hernia repair and management
Baptist Health South Florida
2025
Duke Medical Center
2015-2024
Duke University Hospital
2015-2024
Duke University Health System
2021-2024
Duke University
2013-2023
Sapienza University of Rome
2005-2022
Duke Cancer Institute
2021
Siemens (Germany)
2017-2018
Politecnica Salesiana University
2018
University Radiology
2018
Dual-energy CT provides information about how substances behave at different energies, the ability to generate virtual unenhanced datasets, and improved detection of iodine-containing on low-energy images. Knowing a substance behaves two energies can provide tissue composition beyond that obtainable with single-energy techniques. The term K edge refers spike in attenuation occurs energy levels just greater than K-shell binding because increased photoelectric absorption these levels. K-edge...
Purpose To prospectively compare gadoxetate disodium–enhanced magnetic resonance (MR) imaging with multiphasic 64-section multidetector computed tomography (CT) in the detection of hepatocellular carcinoma (HCC) patients cirrhosis. Materials and Methods Institutional review board approval informed patient consent were obtained for this prospective study. Fifty-eight (39 men, 19 women; mean age, 63 years; age range, 35–84 years) underwent MR CT. The examinations performed within 30 days each...
Purpose To characterize the noise and spatial resolution properties of a commercially available deep learning‐based computed tomography (CT) reconstruction algorithm. Methods Two phantom experiments were performed. The first used multisized image quality (Mercury v3.0, Duke University) imaged at five radiation dose levels (CTDI vol : 0.9, 1.2, 3.6, 7.0, 22.3 mGy) with fixed tube current technique on commercial CT scanner (GE Revolution CT). Images reconstructed conventional (FBP), iterative...
To intraindividually compare a low tube voltage (80 kVp), high current computed tomographic (CT) technique with standard CT protocol (140 kVp) in terms of image quality, radiation dose, and detection malignant hypervascular liver tumors during the late hepatic arterial phase.This prospective single-center HIPAA-compliant study had institutional review board approval, written informed consent was obtained. Forty-eight patients (31 men, 17 women; age range, 35-77 years) 60 (mean diameter, 20.1...
To investigate whether dual-energy multidetector row computed tomographic (CT) imaging with iodine quantification is able to distinguish between clear cell and papillary renal carcinoma ( RCC ) subtypes.In this retrospective, HIPAA-compliant, institutional review board-approved study, 88 patients (57 men, 31 women) diagnosis of either or at pathologic analysis, who underwent contrast material-enhanced nephrographic phase study December 2007 June 2013, were included. Five readers, blinded...
To intraindividually compare a low-tube-voltage (80 kVp), high-tube-current (675 mA) computed tomographic (CT) technique with high-tube-voltage (140 kVp) CT protocol for the detection of pancreatic tumors, image quality, and radiation dose during parenchymal phase.This prospective, single-center, HIPAA-compliant study was approved by institutional review board, written informed consent obtained. Twenty-seven patients (nine men, 18 women; mean age, 64 years) 23 solitary tumors underwent...
The purpose of our study was to investigate whether virtual unenhanced adrenal nodule attenuation values can replace true noncontrast values.Twenty-three incidentally discovered nodules (19 adenomas and four metastases) were identified in 19 patients (11 men eight women; mean age, 65 years; age range, 38-84 years) who underwent single-energy CT followed by contrast-enhanced dual-energy on the same scanner. A imaging dataset generated from each dataset. measured at location images three...
To investigate whether dual-energy multi-detector row computed tomography (CT) with virtual monochromatic imaging can overcome renal cyst pseudoenhancement in a phantom experiment and clinical study.This retrospective single-center HIPAA-compliant study was approved by the institutional review board, waiver of informed consent. Four compartments inserted into torso phantoms were filled saline to simulate unenhanced state iodinated solutions three levels parenchyma enhancement (140, 180, 240...
Background Low-density lipoprotein receptor-related protein 1b (encoded by LRP1B ) is a putative tumor suppressor, and preliminary evidence suggests LRP1B- mutated cancers may have improved outcomes with immune checkpoint inhibitors (ICI). Methods We conducted multicenter, retrospective pan-cancer analysis of patients alterations treated ICI at Duke University, Johns Hopkins University (JHU) Michigan (UM). The primary objective was to assess the association between overall response rate...
<h3>Background</h3> Resistance to immune checkpoint inhibitors (ICIs) has been linked local immunosuppression independent of major ICI targets (e.g., PD-1). Clinical experience with response prediction based on PD-L1 expression suggests that other factors influence sensitivity ICIs in non-small cell lung cancer (NSCLC) patients. <h3>Methods</h3> Tumor specimens from 120 NSCLC patients 10 institutions were evaluated for by immunohistochemistry, and global proliferative profile targeted...
Dual-Energy CT for Characterization of Adrenal Nodules: Initial ExperienceRajan T. Gupta1, Lisa M. Ho1, Daniele Marin1, Daniel Boll1, Huiman X. Barnhart2 and Rendon C. Nelson1Audio Available | Share
Purpose: To prospectively investigate whether combined interpretation of dynamic and hepatobiliary phase magnetic resonance (MR) images can improve the accuracy gadobenate dimeglumine–enhanced MR imaging in detection hepatocellular carcinoma (HCC) compared with either or multiphasic multidetector computed tomographic (CT) alone. Materials Methods: Institutional review board approval informed patient consent were obtained. Fifty-two patients (39 men, 13 women; mean age, 68 years; range, 38–81...
<b>Background:</b> Neurologic hallmarks of Fabry disease (FD) include small fiber neuropathy as well cerebral micro- and macroangiopathy with premature stroke. Cranial MRI shows progressive white matter lesions (WML) at an early age, increased signal intensity in the pulvinar, tortuosity dilatation larger vessels. To unravel most promising imaging tool for detection CNS involvement FD we compared diagnostic utility different MR findings. <b>Methods:</b> Twenty-five clinically affected...
The objective of our study was to assess the accuracy iodine-related attenuation and iodine quantification as imaging biomarkers uptake in renal lesions on a single-phase nephrographic image with dual-energy MDCT.Fifty-nine patients (41 men, 18 women; age range, 28-84 years) 80 underwent contrast-enhanced CT during phase enhancement. Renal were characterized enhancing or nonenhancing color-coded overlay maps using (in Hounsfield units) milligrams per milliliter). For thresholds 15 20 HU...
To determine whether contrast material-enhanced dual-energy multidetector computed tomography (CT) with material decomposition analysis allows differentiation of adrenal adenomas from nonadenomatous lesions and to compare findings those nonenhanced CT.This retrospective HIPAA-compliant study was approved by the institutional review board Duke University, waiver informed consent. Thirty-eight nonconsecutive patients (22 men 16 women; mean age, 65 years) 47 nodules underwent contrast-enhanced...
Purpose To determine whether single-phase contrast material–enhanced dual-energy material attenuation analysis improves the characterization of small (1–4 cm) renal lesions compared with conventional measurements by using histopathologic and follow-up imaging as clinical reference standards. Materials Methods In this retrospective, HIPAA-compliant, institutional review board–approved study, 136 consecutive patients (95 men 41 women; mean age, 54 years) 144 (111 benign, 33 malignant)...
To determine the variance in virtual monochromatic computed tomography (CT) numbers from same lesion, comparing two clinically available dual-energy multidetector CT hardware implementations (single-source projection-based and dual-source image-based), a phantom-based simulated abdominal environment.This study was exempt institutional review board oversight. Polyethylene terephthalate spheres (15 18 mm) with iodine-to-saline dilutions (0.8 1.2 mg of iodine per millilliter) were serially...