A5021215502- Hydrogels: synthesis, properties, applications
- 3D Printing in Biomedical Research
- Cellular Mechanics and Interactions
- Proteoglycans and glycosaminoglycans research
- Analytical Chemistry and Sensors
- Microfluidic and Capillary Electrophoresis Applications
- Electrohydrodynamics and Fluid Dynamics
- Biochemical and Structural Characterization
- Water Quality Monitoring and Analysis
- Renewable energy and sustainable power systems
- Protein purification and stability
- Electrospun Nanofibers in Biomedical Applications
- Combustion and Detonation Processes
- Graphene and Nanomaterials Applications
- Tissue Engineering and Regenerative Medicine
- Mechanical and Optical Resonators
- Thermochemical Biomass Conversion Processes
- Microfluidic and Bio-sensing Technologies
- Tendon Structure and Treatment
- Analytical Chemistry and Chromatography
- Polymer Surface Interaction Studies
- Signaling Pathways in Disease
Leibniz Institute of Polymer Research
2020-2025
Boehringer Ingelheim (Germany)
2021
University of Freiburg
1966
Abstract Developing tissue is typically soft, highly hydrated, dynamic, and increasingly heterogeneous matter. Recapitulating such characteristics in engineered cell‐instructive materials holds the promise of maximizing options to direct formation. Accordingly, progress design multiphasic hydrogel expected expand therapeutic capabilities engineering approaches relevance human 3D vitro disease models. Recently pioneered methodologies allow for creation systems suitable template guide dynamic...
While autoregulative adaptation is a common feature of living tissues, only few feedback-controlled adaptive biomaterials are available so far. This paper herein reports new polymer hydrogel platform designed to release anti-inflammatory molecules in response the inflammatory activation human blood. In this system, peptide drugs, targeting either complement cascade, receptor, or cyclophilin A, conjugated by sequence that cleaved elastase released from activated granulocytes. As proof...
Abstract Mit dem Ziel, die Molekulargewichtsverteilung Polymerer registrierend zu ermitteln, wurde zunächst eine Trennkolonne vom Baker‐Williams‐Typ entwickelt, anstatt des üblichen Lösungsmittel/Fällungsmittel‐Gemisches nur ein kritisches Lösungsmittel verwendet. Die Konzentration der nach Molekulargewicht aufgetrennten Polymeren im Eluat Kolonne wird kontinuierlich mittels eines Differentialrefraktometers bestimmt. — Außerdem Kapillarkolonne für Fraktionierung kleinster Polymermengen...
Microfluidic synthesis options of monodisperse poly(ethylene glycol) hydrogel microparticles for microinterferometric biosensing were evaluated with a focus on introducing reactive surface moieties.
Abstract The delivery of chemotactic signaling molecules via customized biomaterials can effectively guide the migration cells to improve regeneration damaged or diseased tissues. Here, we present a novel biohybrid hydrogel system containing two different sulfated glycosaminoglycans (sGAG)/sGAG derivatives, namely either mixture short heparin polymers (Hep-Mal) structurally defined nona-sulfated tetrahyaluronans (9s-HA4-SH), precisely control release charged molecules. polymer networks are...
Abstract Concentration gradients of soluble signaling molecules—morphogens—determine the cellular organization in tissue development. Morphogen‐releasing microgels have shown potential to recapitulate this principle engineered constructs, however, with limited control over molecular cues space and time. Inspired by functionality sulfated glycosaminoglycans (sGAGs) morphogen vivo, a library sGAG‐based is developed designated as µGel Units Instruct Development (µGUIDEs). Adjustment microgel's...
Multiphasic cell- and tissue-instructive hydrogels create unprecedented options to account for the spatial heterogeneity dynamic nature of tissues organs in engineered living matter. In article number 1908857, Petra B. Welzel, Carsten Werner, co-workers summarize current design concepts methods fabrication gel-in-gel materials highlight potential this emerging class biomaterials.