A5039132169- Multi-Criteria Decision Making
- Fuzzy Systems and Optimization
- Blood properties and coagulation
- Decision-Making and Behavioral Economics
- Protease and Inhibitor Mechanisms
- Bayesian Modeling and Causal Inference
- Statistical Distribution Estimation and Applications
- Maritime Navigation and Safety
- Maritime Transport Emissions and Efficiency
- Reliability and Maintenance Optimization
- Risk and Safety Analysis
- Blood Coagulation and Thrombosis Mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Maritime Ports and Logistics
- Economic and Environmental Valuation
- Vehicle emissions and performance
- Fuzzy Logic and Control Systems
- Sports Analytics and Performance
- Scientific Research and Discoveries
- Coastal and Marine Management
- Probabilistic and Robust Engineering Design
- Neural Networks and Applications
- Atmospheric chemistry and aerosols
- Fault Detection and Control Systems
- Transportation Planning and Optimization
University of Tasmania
2015-2025
Australian Maritime College
2015-2025
Varna Free University
2025
Nikola Vaptsarov Naval Academy
2013-2023
Systems Research Institute
2021
Polish Academy of Sciences
2021
University of Library Studies and Information Technologies
2021
Institute of Information and Communication Technologies
2021
Bulgarian Academy of Sciences
2021
Semmelweis University
1997-2015
Pancreatic cancer is associated with a high incidence of venous thromboembolism. Neutrophils have been shown to contribute thrombosis in part by releasing neutrophil extracellular traps (NET). A recent study showed that increased plasma levels the NET biomarker, citrullinated histone H3 (H3Cit), are thromboembolism patients pancreatic and lung but not those other types cancer, including breast cancer. In this study, we examined contribution neutrophils nude mice bearing human tumors. We...
Arterial thrombi contain variable amounts of red blood cells (RBCs), which interact with fibrinogen through an eptifibatide-sensitive receptor and modify the structure fibrin. In this study, we evaluated modulator role RBCs in lytic susceptibility fibrin.If fibrin is formed at increasing RBC counts, scanning electron microscopy evidenced a decrease fiber diameter from 150 to 96 nm 40% (v/v) RBCs, effect susceptible eptifibatide inhibition (restoring 140 diameter). prolonged lysis time...
(1) Background: Let the continuous parameter X be a proxy variable for outcome of an intervention R. Quasi-experimental studies are designed to evaluate effect R over when forming randomized control group (without intervention) is impractical or/and unethical. The most popular quasi-experimental design, difference-in-differences (DID) method, uses four samples values (pre- and post-intervention experimental pseudo-control groups). DID always quantitatively evaluates X. However, its practical...
The recent advancements in Artificial Intelligence (AI) have profoundly transformed various aspects of our lives, from societal interactions to business operations and educational methodologies. As traditional AI systems grapple with challenges like transparency the lack human-centric adaptability, concept Hybrid-Augmented emerges as a transformative approach. By integrating human cognitive capabilities advanced computational systems, aims overcome such limitations, fostering collaboration...
The maritime transport industry is recognised as one of the cleanest modes global transport. It important to measure engine exhaust emissions maintain its ecological superiority over road, rail, and other forms Emission inventories are needed estimate emissions. Current need review emission factors (EFs) they currently employ, which generally yield over- or under-estimations. There a consider more relevant measurements that will enhance accuracy prediction models. also different mathematical...
A new model has been introduced to characterize the action of a fluid phase enzyme on solid substrate. This approach is applied evaluate kinetics fibrin dissolution with several proteases. The predicts rate constants for formation and dissociation protease-fibrin complex, apparent order association reaction between substrate, as well global catalytic constant (kcat) process. These kinetic parameters show strong dependence nature protease structure polymerized data trypsin, PMN-elastase,...
Abstract The use of autonomous underwater vehicles (AUVs) for various scientific, commercial, and military applications has become more common with maturing technology improved accessibility. One relatively new development lies in the AUVs under‐ice marine science research Antarctic. extreme environment, ice cover, inaccessibility as compared to open‐water missions can result a higher risk loss. Therefore, having an effective assessment risks before undertaking any Antarctic is crucial...
Background-Post-partum haemorrhage (PPH) is the leading cause of maternal death world-wide.The WOMAN trial showed that antifibrinolytic tranexamic acid (TXA) reduces PPH deaths.Maternal anaemia increases risk PPH.The WOMAN-2 now assessing whether TXA can prevent in women with anaemia.Low RBC-counts promote fibrinolysis by altering fibrin structure and plasminogen activation.Objectives-We explored interactions between RBCs inhibiting fibrinolysis.Methods-We used global fibrinolytic assays...
Abstract With the maturing of autonomous technology and better accessibility, there has been a growing interest in use underwater vehicles (AUVs). The deployment AUVs for under‐ice marine science research Antarctic is one such example. However, higher risk AUV loss present during endeavors due to extreme operating environment. To control loss, existing analyses approaches tend focus more on AUV's technical aspects neglect role soft factors, as organizational human influences. In addition,...
Upon platelet activation, free fatty acids are released at the stage of thrombus formation, but their effects on fibrin formation largely unexplored. Our objective was to characterize kinetic thrombin activity, as well structural and mechanical properties resultant clots. Thrombin activity fibrinogen followed by turbidimetry detailed characterization performed using a fluorogenic short peptide substrate. The viscoelastic were measured with rotatory oscillation rheometer, whereas its...
Abstract Progress curve analysis is a convenient tool for the characterization of enzyme action: single reaction mixture provides multiple experimental measured points continuously varying amounts substrates and products with exactly same modulator concentrations. The determination kinetic parameters from progress curves, however, requires complex mathematical evaluation time-course data. Some freely available programs (e.g. FITSIM, DYNAFIT) are widely applied to fit user-defined enzymatic...
The emissions from vessels utilising heavy fuel oil include large amounts of nitrogen oxides, sulphur dioxide and particulate matter, presenting significant health risks to people living near ports. To determine the effect these on human health, complex atmospheric dispersion modelling using CALPUFF assesses ground-level concentrations at receptors surrounding sources. This paper demonstrates application methodology by applying it Port Brisbane for full 2013 calendar year. Various Health...
Removal of C-terminal lysine residues that are continuously exposed in lysing fibrin is an established anti-fibrinolytic mechanism dependent on the plasma carboxypeptidase TAFIa, which also removes arginines at time fibrinogen clotting by thrombin.To evaluate impact alterations structure mediated constitutive activity function as a template for tissue plasminogen activator-(tPA) induced activation and its susceptibility to digestion plasmin.We used stable B (CPB), shows same substrate...
Intravascular fibrin clots are resolved by plasmin acting at the interface of gel-phase substrate and fluid-borne enzyme. The classic Michaelis–Menten kinetic scheme cannot describe satisfactorily this heterogeneous-phase proteolysis because it assumes homogeneous well-mixed conditions. A more suitable model for these spatial constraints, known as fractal kinetics, includes a time-dependence Michaelis coefficient KmF = Km0F(1 + t)h, where h is exponent time, t. aim present study was to build...
Thrombi, which are dissolved primarily by plasmin (EC 3.4.21.7.), contain up to millimolar concentrations of fatty acids and these known affect the action protease. In present study modulation activity was characterized quantitatively in a continuous amidolytic assay based on synthetic substrate (Spectrozyme-PL). A novel numerical procedure applied for identification kinetic parameters their confidence intervals, with Monte Carlo simulation reaction progress curves, providing adequate...
This paper aims to statistically test the null hypothesis H 0 for identity of probability distribution onedimensional (1D) continuous parameters in two different populations, presented by fuzzy samples i.i.d.observations.A degree membership corresponding population is assigned any observations sample.The statistic Kuiper's statistic, which measures between sample cumulative functions (CDF) parameter.A Bootstrap algorithm developed simulation-based approximation CDF Kuiper provided that...
The paper presents a discussion on fuzzy rationality in the elicitation of subjective probabilities and utilities. In addition to previous research, two functions, measuring degree preference real decision maker both sides uncertainty interval are introduced, their relationship with indifference function, over gambles, is analyzed graphically interpreted. A new relation -- hesitation introduced give better description actual process by makers. influence preference-hesitation combination an...