A5069833940- Orthopedic Infections and Treatments
- Orthopaedic implants and arthroplasty
- Infectious Diseases and Tuberculosis
- Bone Tissue Engineering Materials
- Signaling Pathways in Disease
- Pain Management and Opioid Use
- Opioid Use Disorder Treatment
- Macrophage Migration Inhibitory Factor
- Bacterial biofilms and quorum sensing
- Spine and Intervertebral Disc Pathology
- Vitamin K Research Studies
- Anesthesia and Pain Management
- Dental Implant Techniques and Outcomes
Johns Hopkins Medicine
2023-2025
Johns Hopkins University
2023-2025
Westchester Medical Center
2025
New York Medical College
2024
To (1) create a novel tissue-engineered bone graft comprising the osteoinductive oxysterol Oxy133 and (2) compare osteogenic capability of this with substitutes previously examined.
INTRODUCTION: Osteoinductive oxysterols present a promising small-molecule alternative to rhBMP-2 promote bone formation. However, few reports have investigated the use of when administered as an adjuvant in tissue-engineered grafts for spinal fusion. METHODS: Oxy133 was incorporated into biomimetic graft substitute (BioMim) comprising extracellular matrix (ECM) and calcium phosphate; low-dose (2 mg Oxy133/graft, BioMim-Oxy133-Lo) high-dose (20 BioMim-Oxy133-Hi) formulations were produced....
BackgroundPostoperative infection is a complication of spinal fusion surgery resulting in increased patient morbidity. Strategies including intraoperative application powdered vancomycin have been proposed to reduce the incidence infection; however, such antimicrobial effects are short-lived.MethodsInstrumentation L4-L5 vertebrae was performed mimicking pedicle screw and rod fixation 30 rats. Titanium instrumentation inoculated with either PBS or 1 × 105 CFU bioluminescent MRSA, along...
OBJECTIVE Infuse bone graft is a widely used osteoinductive adjuvant; however, the simple collagen sponge scaffold in implant has minimal inherent properties and poorly controls delivery of adsorbed recombinant human morphogenetic protein–2 (rhBMP-2). In this study, authors sought to create novel substitute material that overcomes limitations compare ability with facilitate union following spine surgery clinically translatable rat model spinal fusion. METHODS The created polydopamine...
Systematic review.
INTRODUCTION: Postoperative infection is a complication of spinal fusion surgery resulting in increased patient morbidity. Strategies including intraoperative application powdered vancomycin have been proposed to reduce the incidence infection, however such antimicrobial effects are short-lived. METHODS: Instrumentation L4-L5 vertebrae was performed mimicking pedicle screw and rod fixation 30 rats. Titanium inoculated with PBS or 1x105 CFU bioluminescent MRSA biomimetic bone grafts infused...