A5067042333- RNA Research and Splicing
- Genomics and Chromatin Dynamics
- Genetics, Aging, and Longevity in Model Organisms
- RNA modifications and cancer
- Developmental Biology and Gene Regulation
- Chromosomal and Genetic Variations
- Adipose Tissue and Metabolism
- Amyotrophic Lateral Sclerosis Research
- Molecular Biology Techniques and Applications
- Mitochondrial Function and Pathology
- Genetic Neurodegenerative Diseases
- Neurology and Historical Studies
- CRISPR and Genetic Engineering
- RNA Interference and Gene Delivery
University of Lausanne
2022-2025
Max Planck Institute of Molecular Cell Biology and Genetics
2022
Centre National de la Recherche Scientifique
2020
Biologie du Développement et Cellules Souches
2020
Institut Pasteur
2020
Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)
2019
Instituto di Biofisica
2019
Abstract The localization of transcriptional activity in specialized transcription bodies is a hallmark gene expression eukaryotic cells. It remains unclear, however, if and how affect expression. Here we disrupted the formation two prominent endogenous that mark onset zygotic zebrafish embryos analysed effect on using enriched SLAM-seq live-cell imaging. We find disruption results misregulation hundreds genes. focus genes are upregulated. These have accessible chromatin poised to be...
ABSTRACT An important hallmark of aging is the loss proteostasis, which can lead to formation protein aggregates and mitochondrial dysfunction in neurons. Although it well known that synthesis finely regulated brain, especially at synapses, where mRNAs are locally translated activity-dependent manner, little as changes synaptic proteome transcriptome during aging. Therefore, this work aims elucidate relationship between soma level Proteomic transcriptomic data analysis reveal that, young...
ABSTRACT The localization of transcriptional activity in specialized transcription bodies is a hallmark gene expression eukaryotic cells. How proteins the machinery come together to form such bodies, however, unclear. Here, we take advantage two large, isolated, and long-lived that reproducibly during early zebrafish embryogenesis, characterize dynamics body formation. Once formed, these are enriched for initiating elongating RNA polymerase II, as well factors Nanog Sox19b. Analyzing events...
Hormesis refers to a biphasic intensity-dependent response stressors where low-intensity or short-duration exposure potentially noxious induces long-lasting adaptations that have positive physiological effects [1]. It was proposed life-extending interventions, such as calorie restriction, retard aging via their hormetic action [2]. More recently, it shown transient burst of reactive oxygen species is required induce the restriction [3], physical exercise [4], inhibition insulin/IGF-I pathway...
The localization of transcriptional activity in specialized transcription bodies is a hallmark gene expression eukaryotic cells. It remains unclear, however, if and how they affect expression. Here, we disrupted the formation two prominent endogenous that mark onset zygotic zebrafish embryos analysed effect on using enriched SLAM-Seq live-cell imaging. We find disruption results downregulation hundreds genes, providing experimental support for model which increase efficiency transcription....