A5103124184- Breast Cancer Treatment Studies
- Balance, Gait, and Falls Prevention
- Breast Lesions and Carcinomas
- Cerebral Palsy and Movement Disorders
- Stroke Rehabilitation and Recovery
- Breast Implant and Reconstruction
- Appendicitis Diagnosis and Management
- Chronic Lymphocytic Leukemia Research
- Physical Activity and Health
- Intraperitoneal and Appendiceal Malignancies
- Bone health and osteoporosis research
- Global Cancer Incidence and Screening
- Radiomics and Machine Learning in Medical Imaging
- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- HIV/AIDS drug development and treatment
- Biochemical and Molecular Research
- Cardiac Health and Mental Health
- Cancer Risks and Factors
- Bone and Joint Diseases
- Innovative Human-Technology Interaction
- Acute Lymphoblastic Leukemia research
- Esophageal Cancer Research and Treatment
- Health and Wellbeing Research
Uppsala University
2015-2024
Västmanlands sjukhus Västerås
2014-2024
Mälardalen University
2019-2023
Umeå University
2006-2021
Eskilstuna Municipality
2021
Center for Clinical Research Dalarna
2015-2020
Karolinska Institutet
1988-2018
Lund University
2011
Danderyds sjukhus
1997-2006
Västerås Municipality
2006
In a prospective controlled study the effect of antibiotics as only treatment in acute appendicitis was evaluated. Of 40 patients admitted with duration abdominal pain less than 72 h, 20 received intravenously for 2 days followed by oral 8 and considered controls were randomized to surgery. All treated conservatively discharged within days, except one who required surgery after 12 h because peritonitis secondary perforated appendicitis. Seven readmitted 1 year result recurrent underwent...
The two thymidine (dThd) kinases in human cells, the cytosolic, S-phase-specific TK1 and mitochondrial, constitutively expressed TK2 were purified to homogeneity as judged from sodium dodecyl sulfate-gel electrophoresis. substrate specificity of toward natural substrates important nucleoside analogues was compared. With TK1, Km values for 5-fluorodeoxyuridine (FdUrd), 3'-azido-2',3'-dideoxythymidine (AZT), 3'-fluoro-2',3'-dideoxythymidine (FLT) 2.2, 0.6, 2.1 microM compared 0.5 dThd 9...
A total of 149 patients in 7 centers Denmark, Norway and Sweden entered a 6‐week double‐blind trial intended to assess the antidepressant effect safety citalopram vs placebo depressed elderly (65 years age or older) who might also suffer from somatic disorders and/or senile dementia. Results ratings on Hamilton Rating Scale for Depression, Montgomery‐Åsberg Depression Clinical Global Impression provided consistent evidence that citalopram‐treated improved more than placebo‐treated patients....
The aim of the study is to compare efficacy SPIO as a tracer in sentinel node biopsy (SNB) breast cancer with Tc and patent blue multicentre prospective perform meta-analysis all published studies. It also aims follow skin discoloration after injection describe when how it resolves. Totally 206 patients early were recruited. administered standard fashion. Patients injected (Sienna+) preoperatively. SNB was performed detection rates recorded for both methods. Skin followed documented...
Difficulty in preoperatively assessing the risk for occult invasion or surgery that precludes future accurate axillary mapping patients with ductal cancer situ (DCIS) account overutilization of SLND.
The relative importance of motor, perceptual, and some cognitive functions for self-care ability was analyzed in a representative sample 109 subjects within 2 weeks acute stroke. Forty-nine patients (45%) were dependent or partly self-care. Profound motor dysfunction present 39%, low-order perceptual deficits 10%, high-order 60%, disorientation time space 13% the patients. There significant covariation between function perception orientation function. Low-order covaried only weakly....
Abstract Background Superparamagnetic iron nanoparticles perform comparably to radioisotope ± blue dye for sentinel lymph node detection in breast cancer, even when injected up 8 weeks before surgery. Using superparamagnetic after primary systemic therapy, and the maximum time frame of nanoparticle administration have not been investigated. Methods This cohort study included cN0/1-to-ycN0 patients undergoing or targeted axillary dissection. All received either therapy surgery, on day Results...
When a tourniquet is used during surgery on the extremities, pressure applied to muscles, nerves and blood vessels can cause neuromuscular damage that contributes postoperative weakness. The hypothesis was rehabilitation-related results would be improved if total knee arthroplasty (TKA) performed without use of tourniquet.81 patients with osteoarthritis who underwent TKA were randomized or tourniquet. Active flexion extension knee, pain by visual analog scale (VAS), swelling circumference,...
Metabolite-protein interactions define the output of metabolic pathways and regulate many cellular processes. Although diseases are often characterized by distortions in processes, efficient means to discover study such directly cells have been lacking. A stringent implementation proteome-wide Cellular Thermal Shift Assay (CETSA) was developed applied key nucleotides, where previously experimentally confirmed protein-nucleotide were well recaptured. Many predicted, but never confirmed, as...
Superparamagnetic iron oxide nanoparticles (SPIO) are non-inferior to radioisotope and blue dye (RI + BD) for sentinel lymph node (SLN) detection. Previously, 2 mL SPIO (Sienna+®) in 3 NaCl was used. In this dose-optimizing study, lower doses of a new refined solution (Magtrace®) (1.5 vs. 1.0 mL) were tested different timeframes (0–24 h perioperative 1–7 days preoperative) injections sites (subareolar peritumoral). Two consecutive breast cancer cohorts (n = 328) scheduled SLN-biopsy included...
This study investigated if behavioral factors, treatment with support, readiness to change, fall self-efficacy, and activity habits could predict long-term adherence an exercise program. Included in this were 114 community-dwelling older adults who had participated one of two home-based interventions. Behavioral factors associated the program over 52 weeks analyzed. The specifically at baseline, significantly predicted program, odds ratio = 3.39, 95% confidence interval [1.38, 8.32], for...
In Western countries, falls and fall-related injuries are a well-known threat to health in the aging population. Studies indicate that regular exercise improves strength balance can therefore decrease incidence of injuries. The challenge, however, is provide programs safe, effective, attractive older aim this study was investigate short-term effect home-based program with or without motivational interviewing (MI) compared standard care on physical performance, fall self-efficacy, balance,...
The bone mineral density was determined by dual-photon absorptiometry on the proximal femur in 32 women with femoral neck fractures, 30 trochanteric 39 a fracture elsewhere than hip, and 16 premenopausal healthy women. Single-photon performed at two sites radius. intertrochanteric area greater fractures those fractures. distribution essentially same for group as reference of Neither Singh index, radiographs, nor measurements radius single photon provided reliable estimate femur.
Background: It is a challenge to promote exercise among older persons. Knowledge needed regarding the maintenance of aiming at preventing falls and promoting health well-being in Purpose: This descriptive study used qualitative inductive approach describe persons' experiences fall-preventive, home-based program with support for behavioral change. Methods: Semi-structured interviews were conducted 12 elderly persons aged 75 years or older, content analysis was performed. Results: Four...
This cohort study uses registry data to report the long-term outcomes of patients who participated in randomized clinical trials antibiotics vs surgery Sweden 1990s.