Grape seed proanthocyanidine extract (GSPE) is a strong antioxidant derived from the grape seeds (Vitis vinifera, Terral J.F.) and has polyphenolic structure with wide range of biological activity. The aim present study was to evaluate effects GSPE on alveolar bone loss histopathological changes in rats diabetes mellitus ligature-induced periodontitis.Forty were divided into 6 groups. Control (C, rats) group, periodontitis (P, (D, (D+P, diabetes, 100 mg/kg/day (GSPE-100, 8 rats), 200...

Periodontal disease is the chronic infectious of periodontium. Because irreversibility, prevention one most important goals periodontal treatment. The aim this study was to evaluate effect luteolin, a powerful anti-inflammatory agent, on experimental periodontitis by determining morphological and histological tissue alterations.This consisted 28 rats four groups: healthy control group (C, n = 6); (P, 50 mg/kg luteolin administered (L-50, 8); 100 (L-100, 8). Experimental induced via ligature...

Astaxanthin is a keto-carotenoid that has strong antioxidant effect. The purpose of this study was to evaluate the effects astaxanthin on alveolar bone loss and histopathological changes in ligature-induced periodontitis rats.Wistar rats were divided into four experimental groups: non-ligated (C, n = 6); ligature only (L, (1 mg/kg/day astaxanthin, AS1 group, 8); (5 AS5 8). Silk ligatures placed at gingival margin lower first molars mandibular quadrant. duration 11 days animals killed end...

The present study aimed to evaluate proinflammatory cytokine and vitamin D levels in rheumatoid arthritis (RA) chronic periodontitis (CP) patients healthy individuals before after initial periodontal treatment. Overall, 17 CP with RA (RA + CP), 18 systemically (CP), controls (C) were included. Clinical measurements recorded gingival crevicular fluid (GCF) blood samples recorded. received nonsurgical Vitamin D, tumor necrosis factor (TNF)-α, receptor activator of nuclear factor-KB ligand...

The aim of this study examines the effect systemic melatonin administration on proinflammatory cytokine levels, apoptosis, alveolar bone loss (ABL), lipid metabolism, and diabetic control in rats with diabetes mellitus (DM) ligature-induced periodontitis.Fifty-two male Wistar were used study. Study groups as follows: 1) non-ligated (NL, n = 6); 2) streptozotocin (STZ, 8); 3) STZ (STZ+Mel, 4) ligature (L, 5) (L+Mel, 6) (STZ+L, 7) STZ, ligature, (STZ+L+Mel, 8). DM was induced by...

Anti-inflammatory cytokines play a crucial role in periodontitis by inhibiting synthesis of pro-inflammatory cytokines. The purpose this study was to evaluate the effect interleukin-10 (-597) gene polymorphism and genotype distributions on chronic (CP) development IL-6 IL-10 levels gingival crevicular fluid (GCF) serum before after non-surgical periodontal treatment.The population consisted 55 severe generalized CP patients as group 50 healthy individuals control group. Plaque index, probing...

Abstract Objective Smoking causes pathological changes in all tissues, including gingiva and alveolar bone. The aim of present study was to evaluate apoptotic tissue alterations destruction smoker non‐smoker periodontitis patients healthy individuals. Methods Gingival biopsy samples from 15 systemically orally individuals (Group 1), 2), smokers 3), 4) were enrolled the study. Clinical periodontal measurements as plaque index (PI), gingival (GI), clinical attachment levels (CAL) recorded,...

Abstract Background and Objective Periodontitis is the chronic destructive disease of periodontium, which causes severe inflammation in tissues. Cinnamic acid as an unsaturated carboxylic might prevent periodontal destruction. The present study aimed to evaluate effects cinnamic two different forms free liposome on experimental periodontitis Wistar rats. Methods Thirty‐two female rats were used study. Four main groups created follows: C: control group; P: C‐P: acid‐administered CL‐P: applied...

Objective. The purpose of this study was to evaluate the effects systemically administered boric acid on alveolar bone loss, histopathological changes and oxidant/antioxidant status in ligature-induced periodontitis diabetic rats. Materials methods. Forty-four Wistar rats were divided into six experimental groups: (1) non-ligated (NL, n = 6) group, (2) ligature only (LO, (3) Streptozotocin (STZ, 8) (4) STZ (STZ+LO, (5) STZ, systemic administration 15 mg/kg/day for days (BA15, group (6) 30...

Diabetes mellitus and periodontitis are chronic inflammatory diseases that disrupt soft tissue metabolism. The separately or together increase apoptosis in gingival fibroblast cells reduce cell renewal. We investigated the effects of diabetes on composition structure connective tissue. used biopsies from 16 healthy individuals (control group, C), type 2 diabetic patients with (diabetes + D P) (periodontitis P). Biopsies were obtained under local anesthesia. Clinical attachment level (CAL),...

Abstract The Objective present study aimed to evaluate the effects of oleuropein on ligature‐induced alveolar bone loss. In this respect, osteoblastic activity, osteoclastic inflammatory markers, and apoptosis were evaluated. Background Oleuropein is a flavonoid, which has potent anti‐inflammatory bone‐protective effects. Methods Thirty‐two Wistar rats divided into four experimental groups as following: control (C, n = 8) group; periodontitis (P, low‐dose group (12 mg/kg/day oleuropein, LDO...

The aim of this study is to investigate the effects systemically administered boric acid on osteoporosis-related bone alterations, alveolar loss, receptor activator nuclear factor kappa-b ligand (RANKL) expressions, and mandibular density in experimental periodontitis model osteoporotic rats. Thirty-six male Wistar rats were separated into five groups: nonligated control (C, n = 6) group; (P, osteoporosis (O, 8) + (O+P, group, with 50 mg/kg/d (BA50, group for 15 days. Osteoporosis was...

Objective: The aim of present study was to determine the effects conjugated linoleic acid enriched milk on alveolar bone loss, hyperglycaemia, oxidative stress and apoptosis in ligature-induced periodontal disease diabetic rat model.Methods: Wistar rats were divided into six experimental groups: 1; non-ligated (NL, n = 6) group, 2; ligature only (LO, 3; streptozotocin (STZ, 8) 4; STZ (STZ + L, 5; (CLA) (L CLA, 6; STZ, CLA group L group. Diabetes mellitus induced by 60 mg/kg streptozotocin....

Hyaluronic acid (HA) is found in connective tissue and participates wound healing. We investigated the efficacy of a HA gel (2% hyaluronic acid; 1% antioxidants, coenzyme Q10 vitamin E; 5% benzocaine) on healing palatal wounds rats. established two groups rats: control group treated with vehicle an gel. The was divided into five subgroups four according to day which animals were sacrificed. Wounds created by elevating 5 mm diameter full thickness flaps. Healed unhealed areas measured using...

Aim: Quercetin is an antioxidant agent with proven beneficial effects in preventing inflammation. Aim of present study was to evaluate quercetin gel on a secondary intention wound healing model Wistar rats. Material and Methods: 42 rats were divided into two groups, one group administered (Q, n=18) while other vehicle (C, n=24). 5-mm diameter palatal wounds created each rat all given either or daily until sacrification days. Gel contained 5% quercetin, benzocaine glycerin, 0.2 ml every day....

Objective: Aim of present study was to evaluate gingival tissue samples obtained from healthy and diseased sites teeth dental implants in terms hypoxia collagenase activity.Methods: Four groups were created as Group-1; individuals (H), Group-2; periodontitis patients with stage 3 grade B (P), Group-3; peri-implant mucositis. Group-4; peri-implantitis (P-IMP). Plaque index (PI), (GI) probing pocket depth (PPD) recorded. Gingival mucosal biopsies obtained. Fibroblast inflammatory cells...

Colchicine is widely used in the treatment of several inflammatory diseases due to its anti-inflammatory effect, but effects on bone metabolism are unclear. The aim this study was evaluate systemically-administered colchicine healthy periodontium and experimentally-induced periodontitis. In total, 42 male Wistar rats were included study. A non-ligated group constituting negative control (Control, C, n = 6) a ligature-only forming positive (LO, 12) created separately. Twelve treated with 0.4...

Present study suggests that diseased sites of periodontitis with stage 3 grade B and C had decreased fibroblast cell density, hypoxia-inducible factor (HIF) vascular endothelial growth (VEGF) expressions while increased inflammatory counts compared to both healthy the patients controls. Collagen maturation enzymes also in sites. Objective: The present aimed at determining markers hypoxia collagen crosslinking gingiva from individuals patients. Methods: Group-1; individuals, Group-2;...

Aim: Periodontal diseases are chronic, inflammatory and infectious diseases. Therefore, periodontal treatment aims to eliminate periodontopathogenic bacteria causing The aim of present study was evaluate the effect a bacterial end metabolite, acetic acid, on bacteria, Streptococcus gordonii Eikenella corrodens.Material Method: In research, corrodens (ATCC® 23834™) (NCTC 7870) were tested. Acetic acid used in 5% concentration dissolved distilled water. Negative control agent water positive...

Aim: Depression is a multi-factorial disease characterized by variety of symptoms. Individuals with psychiatric disorders areseem to be more prone periodontitis. However, depression and periodontal can considered bidirectional risk factors.Periodontal diseases also an effect on depression. The aim this study determine the non-surgical mechanicalperiodontal treatment psychological state.Materials Methods: Two randomized groups were established from depressed patients non-treated diseases.Test...

Preclinical studies are crucial in studying the etiology and pathogenesis of human diseases especially with multifactoriel such as diabetes, cardiovascular periodontitis. Studies animal models complementary to vitro experiments prior clinical trials. Every model has its own advantage disadvantage there is not any suitable for all kinds studies. To find optimal experimental species a major issue researchers. In this mini-review I aimed review used field periodontology relatively novel...