A5039773248- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Peptidase Inhibition and Analysis
- Mycobacterium research and diagnosis
- Fungal Infections and Studies
- melanin and skin pigmentation
- Antimicrobial Peptides and Activities
- Autoimmune and Inflammatory Disorders
- Cancer-related gene regulation
- Prostate Cancer Treatment and Research
- Glycosylation and Glycoproteins Research
- Actinomycetales infections and treatment
- Diet and metabolism studies
Guangzhou Medical University
2021-2024
First Affiliated Hospital of GuangXi Medical University
2018-2020
Guangxi Medical University
2018-2020
Abstract Background Hepatocellular carcinoma (HCC) remains a medical challenge due to its high proliferation and metastasis. Although deubiquitinating enzymes (DUBs) play key role in regulating protein degradation, their pathological roles HCC have not been fully elucidated. Methods By using biomass spectrometry, co-immunoprecipitation, western blotting immunofluorescence assays, we identify ribosomal S16 (RPS16) as substrate of ubiquitin-specific peptidase 1 (USP1). The USP1-RPS16 axis the...
Abstract Androgen receptor splice variant 7 (AR-V7), a form of ligand-independent and constitutively activating androgen (AR), is considered as the key driver to initiate castration-resistant prostate cancer (CRPC). Because AR-V7 lacks ligand-binding domain, AR-targeted therapies that aim inactivate AR signaling through disrupting interaction between are limited in CRPC. Thus, emergence has become greatest challenge for treating Targeting protein degradation recently proposed novel avenue...
HER2 is a transmembrane receptor with intrinsic tyrosine kinase activity that overexpressed in almost 25% of human breast cancers. Here, we report the neddylation new post-translational modification controls its expression and oncogenic cancer. Two critical members pathway, NEDD8 NEDD8-activating enzyme E1 subunit 1 (NAE1), are detected specimens. Overexpressed NAE1 positively correlated Subsequent structure function experiments show directly interacts NAE1, whereas protein decreased by...