A5043977012- Phagocytosis and Immune Regulation
- Photonic and Optical Devices
- Immune cells in cancer
- Monoclonal and Polyclonal Antibodies Research
- Quantum Dots Synthesis And Properties
- Smart Grid Security and Resilience
- Optimal Power Flow Distribution
- Acoustic Wave Resonator Technologies
- Plasmonic and Surface Plasmon Research
- Statistical Methods and Bayesian Inference
- Cell Image Analysis Techniques
- Power Systems and Technologies
- Statistical Methods in Clinical Trials
- Nanocluster Synthesis and Applications
- Heavy Metal Exposure and Toxicity
- Semiconductor Quantum Structures and Devices
- Neuroinflammation and Neurodegeneration Mechanisms
- Optical properties and cooling technologies in crystalline materials
- Perovskite Materials and Applications
- Extracellular vesicles in disease
- Advanced Causal Inference Techniques
- Neuroscience and Neuropharmacology Research
- Silicone and Siloxane Chemistry
- Asian Geopolitics and Ethnography
- Adenosine and Purinergic Signaling
University of Kentucky
2019-2023
Sanofi (United States)
2022
Metal halide perovskite nanocrystals (NCs) are attractive materials for optoelectronics. However, further improvements in stability, reproducibility, and photoluminescence quantum yield (ΦPL) essential enabling future applications. Inadequate surface passivation is a major cause of instability, irreproducibility, less than unity ΦPL. Herein, we probe the influence multiple ligand binding groups on colloidal stability ΦPL CsPbBr3 (NCs). We find that post-synthetic treatment with dodecanethiol...
Tumor-associated macrophages are the predominant immune cells present in tumor microenvironment and mostly exhibit a pro-tumoral M2-like phenotype. However, macrophage biology is reversible allowing them to acquire an anti-tumoral M1-like phenotype response external stimuli. A potential therapeutic strategy for treating cancer may be achieved by modulating from M2 with microenvironment. Here, programmed nanovesicles generated as immunomodulatory platform capability re-polarize toward...
The capability of quantum dots to generate both single and multiexcitons can be harnessed for a wide variety applications, including those that require high optical gain. Here, we use time-correlated photoluminescence (PL) spectroscopy demonstrate the isolation CdSeTe/ZnS core-shell, nanocrystal (QDs) in Zero Mode Waveguides (ZMWs) leads significant modification PL intensity, blinking dynamics, biexciton behavior. QDs aluminum ZMWs (AlZMWs) exhibited 15-fold increase emission, indicating...
Zero-mode waveguides (ZMWs) are capable of modifying fluorescence emission through interactions with surface plasmon modes leading to either plasmon-enhanced or quenching. Enhancement requires spectral overlap the absorption fluorophore. Thus, enhancement is limited fluorophores in resonance metals (e.g. Al, Au, Ag) used for ZMWs. The ability tune match a wider range across visible spectra would significantly extend utility We fabricated ZMWs composed aluminum and gold individually also...
Single molecule imaging and spectroscopy are powerful techniques for the study of a wide range biological processes including protein assembly trafficking. However, in vivo single biomolecules has been challenging because difficulties associated with sample preparation technical challenges isolating proteins within system. Here we provide detailed protocol to conduct ex where transmembrane isolated by rapidly extracting nanovesicles containing receptors interest from different regions brain...
Fluorescent carbon nanodots (CDs) have been highlighted as promising semiconducting materials due to their outstanding chemical and optical properties. However, the intrinsic heterogeneity of CDs has impeded a clear understanding mechanisms behind photophysical In this study, as-prepared are fractionated via chromatography reduce structural analyzed through ensemble single-particle spectroscopies. Many single particles reveal fluorescence intensity fluctuations between two or more discrete...
Astrocytic processes interact with synapses throughout the brain modulating neurotransmitter signaling and synaptic communication. During conditions such as exposure to drugs of abuse neurological diseases, astrocytes respond by altering their morphological functional properties. Reactive astrocyte phenotypes exhibit a bushy morphology altered soma volume an increased number compared resting astrocytes. The reactive astrocytic phenotype also overexpresses proteins one which can be glial...
Liposomal azithromycin (L-AZM) promotes macrophage polarization toward an M2-like phenotype in the context of myocardial infarction that results improved cardiovascular outcomes mice. To improve upon this formulation, we sought to identify optimized stability, and biological activity parameters necessary enhance immunomodulatory efficacy L-AZM. While our parent formulation contains a mixture long-chain saturated phosphatidylcholine phosphatidylglycerol lipids, evaluated series formulations...
Reliability investigation assumes a critical job in structuring and arranging of radial distribution systems that work for insignificant interference client end electric loads.Power are known as the constituent piece power with most noteworthy convergence failure occasions.Despite fact deficiencies have nearby impact when contrasted age transmission ides, significant possibility acceleration occasions rule all more every now again announced from this segment.Mix new innovations,...