A5031605719- Lipoproteins and Cardiovascular Health
- Neurological Disorders and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Ischemic Stroke Management
- Venous Thromboembolism Diagnosis and Management
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Coronary Interventions and Diagnostics
- Advanced Statistical Methods and Models
- Pain Mechanisms and Treatments
- Computational Drug Discovery Methods
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Botulinum Toxin and Related Neurological Disorders
- Brain Metastases and Treatment
- SARS-CoV-2 and COVID-19 Research
- Cancer, Lipids, and Metabolism
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Long-Term Effects of COVID-19
- Blood Pressure and Hypertension Studies
- Lung Cancer Treatments and Mutations
- COVID-19 Clinical Research Studies
- Pain Management and Opioid Use
Clinical Hospital No. 8
2012-2023
Penza State University
2022
Thales (Portugal)
2020-2021
Ministry of Health of the Russian Federation
2021
National Cancer Centre Japan
2020
City Clinical Hospital
2013
Введение. Колоректальный рак (КР) представляет собой крайне гетерогенную группу заболеваний. Молекулярный анализ на наличие соматической мутации генов семейства RAS (KRAS/NRAS/BRAF), определение MSI/dMMR статуса у больных мКРР включено в стандартный алгоритм обследования соответствии с российскими и международными рекомендациями по диагностике лечению рака. Если стандарты для опухолей дикого типа известны, то заболеваний комбинированным биологическим типом наличием мутаций подходы к до конца...
Abstract Background Elevated levels of low-density lipoprotein cholesterol (LDL-C) and glycosylated hemoglobin (HbA1c) are risk factors for cardiovascular complications. This study evaluated LDL-C goal attainment in Russian clinical practice among patients with moderate to very high risk. The also assessed prescribed lipid-lowering therapy primary compared secondary disease (CVD) prevention, predictors attainment, the proportion individuals diabetes mellitus who achieved HbA1c < 7%....
Aim. To estimate in a 12-month study mortality and frequency of recurrent cardiovascular events, dynamics neurological deficit endothelial dysfunction patients with the first-time ischemic stroke treated simvastatin 40 mg/day acute period disease. Materials methods. The efficacy high-dose (40 mg/day) therapy initiated stage was evaluated comparative randomized study. Patients first group (n=97) received standard , second (n=86) also treatment additionally. Combined endpoint (cardiovascular...
Молекулярно-генетическое исследование опухолевого материала при колоректальном раке (КРР) необходимо для обоснованного выбора лекарственной терапии. Решающее значение пациентов с диссеминированным процессом имеет оценка статуса генов RAS, BRAF, HER2, а также микросателлитной нестабильности (MSI). К более редко встречающимся молекулярным маркерам, которые могут повлиять на выбор терапевтического подхода, относятся мутации в гене POLE и перестройки участием тирозинкиназ NTRK1-3, RET ALK. В...
Aim. To evaluate in open 12 month prospective, randomized study the mortality and recurrent cardiovascular events rate, dynamics of neurological deficit, endothelial dysfunc- tion renal function patients with first ischemic stroke hemispheric localization after prescription simvastatin 40 mg daily acute stage disease. Material methods. Patients (n=210) above 18 years age (95 men 115 women) were included into study. two groups. group 1 (n=105) received standard treatment for stroke. 2 mg/day...
The article discusses modern approaches in the treatment of HER2-positive breast cancer (BC) with brain metastases (BM).The patients are subject to multidisciplinary, comprehensive and biologically – oriented treatment, involvement a neurosurgeon radiation therapist make decision considering local BM, as well clinical oncologist choose systemic drug therapy. Local HER2+ BC BM includes surgical and/or radiotherapy. Use targeted anti-HER2 therapy changes “biology” disease from aggressive...
В 24-месячном исследовании оценена эффективность раннего и длительного применения статинов в лечении острого ишемического инсульта полушарной локализации.На первом этапе проанализированы показатели смертности повторных кардиоваскулярных событий, выраженность эндотелиальной дисфункции, динамика липидного профиля, безопасность симвастатина.На втором проведен сравнительный анализ динамики изучаемых параметров зависимости от вида препарата из группы ингибиторов ГМГ-КоА-редуктазы длительности
Direkord is an original drug containing the active substance of dicholine succinate, which improves sensitivity insulin receptors in neurons to insulin. The aim work was select optimal dosage and study efficacy, safety, tolerability Direkord, a solution for intramuscular injection, ischemic stroke patients early recovery period. In total, 132 after first carotid system, confirmed by computed or magnetic resonance imaging, with remoteness from 3 weeks 2 months mean age 64.35±8.03 years, were...
Narcotic drugs have become more available for use, but it is obvious that monotherapy of pain syndrome with narcotic not always effective. Patients sometimes change prescribed opiates to NSAIDs on their own, because effective despite the high risk complications. In this case patient has a grade 2 associated bone metastases taking maximum daily dose tramadol complicated by nausea. Treatment was successfully changed medium doses and dexketoprophen. We consider combination as opiate-sparing...
The objective of the study was evaluation effectiveness tocilizumab in patients with coronavirus infection COVID-19 who were treated intensive care unit an infectious diseases hospital. Material and methods. There carried out a retrospective analysis case histories 40 confirmed severe extremely COVID-19. average age 58.3 ± 1.8 years, total lung lesion volume 83.2 2.0%. Results: survival rate received immunosuppressive therapy combination pulse glucocorticosteroids 55%, 44% 100% involvement....