A5101812411- Wound Healing and Treatments
- Periodontal Regeneration and Treatments
- Dermatologic Treatments and Research
- Liver physiology and pathology
- Organ Transplantation Techniques and Outcomes
- MicroRNA in disease regulation
- Atherosclerosis and Cardiovascular Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Inflammasome and immune disorders
- NF-κB Signaling Pathways
- Lipid metabolism and disorders
- Venomous Animal Envenomation and Studies
- Bioactive Compounds in Plants
- Mangiferin and Mango Extracts
- Acute Kidney Injury Research
- Polymer composites and self-healing
- Cholesterol and Lipid Metabolism
- Phytochemical compounds biological activities
- Building materials and conservation
- Nanocomposite Films for Food Packaging
- Extracellular vesicles in disease
- Immune Response and Inflammation
- Allergic Rhinitis and Sensitization
- Medical Image Segmentation Techniques
- Peroxisome Proliferator-Activated Receptors
Union Hospital
2017-2023
Jilin University
2017-2023
Health Commission of Jilin Province
2019-2023
Union Hospital
2020
Mesenchymal stem cells (MSCs) are increasingly being applied as a therapy for liver fibrosis. Exosomes possess similar functions to their parent cells; however, they safe and effective cell-free reagents with controllable predictable outcomes. In this study, we investigated the therapeutic potential underlying molecular mechanism human bone mesenchymal cells-derived exosomes (hBM-MSCs-Ex) in treatment of We established an 8-week CCl4-induced rat fibrosis model, after which, administered...
Cutaneous wound healing represents a morphogenetic response to injury and is designed restore anatomic physiological function. Human bone marrow mesenchymal stem cell-derived exosomes (hBM-MSC-Ex) are promising source for cell-free therapy skin regeneration.In this study, we investigated the cell regeneration effects its underlying mechanism of hBM-MSC-Ex on cutaneous in rats. In vitro studies, evaluated role two types cells: human keratinocytes (HaCaT) dermal fibroblasts (HDFs)...
We explored the effects of chitosan oligosaccharides (COS) on coronary heart disease (CHD) patients. The component COS was measured by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). CHD patients were evenly assigned into group (COG) and placebo (CG). duration treatment 6 months therapeutic results measuring left ventricular ejection fraction (LVEF) value, Lee scores, quality life (QOL), blood urea nitrogen, serum creatinine. intestinal flora...
Radiation dermatitis is a refractory skin injury caused by radiotherapy. Human fetal skin-derived stem cell (hFSSC) preferable source for therapy and tissue regeneration. In the present study, we investigated repair effect of using hFSSC secretome on radiation model in rats.We prepared studied its effects proliferation tube formation human umbilical vein endothelial (HUVEC) vitro. Furthermore, used Sr-90 radiation-induced rats evaluated vivo.The results showed that significantly promoted...
Citrus aurantium is rich in flavonoids, which may prevent osteosarcoma progression, but its related molecular mechanism remains unclear. Flavonoids were extracted from C. and purified by reparative HPLC. Each fraction was identified using electrospray ionisation mass spectrometry (ESI‐MS). Three main components (naringin, naringenin, hesperetin) isolated . Naringenin inhibited the growth of MG‐63 cells, whereas naringin hesperetin had no inhibitory function on cell growth. ROS production...
Shrimp-derived allergen has a serious impact on people's health. Chitosan oligosaccharide (COS) anti-allergic action but its function shrimp allergen-induced allergy and related molecular mechanisms remain unclear.COS degrees of polymerization (DP) were selected to interact with tropomyosin (TM) IgE was measured. A mouse model food established by receiving TM intraperitoneally. The models treated different concentrations COS. Fecal serum histamine, IgE, IgG1 IgG2a, inflammatory cytokines...
(Scolopendra subspinipes mutilans L. Koch. (SSLK) helps reduce the risk of coronary heart disease (CHD) but its effects on rheumatic (RHD) patients remain unclear. 80 RHD were recruited and randomly assigned into SG (to receive SSLK treatment) CG placebo) groups, intervention lasted for 3 months. The following cardiac indexes measured, including mean arterial pressure (MAP), rate (HR), central venous (CVP), blood lactate, fatigue, shortness breath, palpitation, chest pain. ELISA kits used to...
In order to accurately segment the calcification of vascular in medical images, a level set segmentation method based on CV model is designed. Firstly, image preprocessing carried out, which including that median filter used remove noise, and histogram equalization enhance contrast. Next, according actual need we region interest calcification? And then, adopted calcified points adhere wall vascular. Finally, morphological operation eliminate small noise hole. A large number clinical images...
With the increasing number of obese patients worldwide, metabolic and bariatric surgery (MBS) has quickly become an effective way to treat obesity related diseases such as type 2 diabetes, hypertension, lipid abnormalities, etc. Although MBS important part general surgery, there is still controversy regarding indications for MBS. In 1991, National Institutes Health (NIH) issued a statement on surgical treatment severe other issues, which continues be standard insurance companies, health care...
Chronic kidney disease condition requires regular dialysis; the patients have greater risk of sepsis and high mortality rate compared to general people with sepsis. The adverse cardiac leads in subjects In present work, we studied consequences chronic damage by 5/6 nephrectomy on function mice induced mechanism involved.We used C57BL/6 subjected them nephrectomy; after induction damage, they were either LPS treatment or cecal ligation puncture (CLP) method. test was done echocardiography....
Abstract Background: Cutaneous wound healing represents a morphogenetic response to injury, and is designed restore anatomic physiological function. Human bone marrow mesenchymal stem cells-derived exosomes (hBM-MSCs-Ex) promising source for cell-free therapy skin regeneration. Methods: In this study, we investigated the cell regeneration effects its underlying mechanism of hBM-MSCs-Ex on cutaneous in rats. vitro studies , w e evaluated role two type s : human keratinocytes (HaCaT) dermal...
Abstract Background: Cutaneous wound healing represents a morphogenetic response to injury, and it designed restore anatomic physiological function. Human bone marrow mesenchymal stem cells-derived exosomes (hBM-MSCs-Ex) is promising source for cell-free therapy skin regeneration. Methods: In this study, we investigated the therapeutic effects underlying mechanism of hBM-MSCs-Ex on cutaneous in rats. We assessment role two type cell: human keratinocytes (HaCaT) dermal fibroblasts (HDFs)....
Abstract Background: Cutaneous wound healing represents a morphogenetic response to injury, and is designed restore anatomic physiological function. Human bone marrow mesenchymal stem cells-derived exosomes (hBM-MSCs-Ex) promising source for cell-free therapy skin regeneration. Methods: In this study, we investigated the cell regeneration effects its underlying mechanism of hBM-MSCs-Ex on cutaneous in rats. vitro studies, evaluated role two types cells: human keratinocytes (HaCaT) dermal...