A5012277983- 3D Printing in Biomedical Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Treatments and Mutations
- Eosinophilic Disorders and Syndromes
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Barrier Structure and Function Studies
- Cancer Research and Treatments
- Glioma Diagnosis and Treatment
Université de Sherbrooke
2023-2025
Abstract Addressing the limited responsiveness to immune checkpoint blockade (ICB) in human cancers remains a critical challenge. Efforts over past two decades have primarily focused on enhancing CD8 T cell function and preventing their exhaustion. However, less attention has been given understanding molecular mechanisms that contribute immunosuppressive tumor microenvironment (TME), which impedes infiltration fosters ICB resistance. The TME ICB-resistant tumors is characterized by...
Lung parenchymal hypoxia has emerged as a cardinal feature of idiopathic pulmonary fibrosis (IPF). Hypoxia promotes cancer cell invasion and metastasis through signaling that is dependent upon the lysophosphatidic acid (LPA) receptor, LPA1 (LPAR1). Abundant data indicate LPA1-dependent also enhances lung fibrogenesis in IPF. We recently reported fibroblasts isolated from lungs individuals with IPF have an increased capacity to form subcellular matrix-degradative structures known invadosomes,...
High-grade gliomas (HGG) are aggressive brain tumors associated with short median patient survival and limited response to therapies, driving the need develop tools improve outcomes. Patient-derived xenograft (PDX) models, such as mouse PDX, have emerged potential Avatar platforms for personalized oncology approaches, but difficulty some human grafts grow successfully long time required mice preclude their use HGG.We used a rapid efficient ex-ovo chicken embryo chorioallantoic membrane (CAM)...