A5060814203- Synthesis and Biological Evaluation
- Quinazolinone synthesis and applications
- Flavonoids in Medical Research
- Pharmacological Effects of Natural Compounds
- Pharmacological Receptor Mechanisms and Effects
- Head and Neck Cancer Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuropeptides and Animal Physiology
- Immune Response and Inflammation
- Synthesis of Organic Compounds
- Natural product bioactivities and synthesis
- Neuroscience and Neuropharmacology Research
- Cancer, Hypoxia, and Metabolism
- Plant Toxicity and Pharmacological Properties
- Lung Cancer Research Studies
- Synthesis and bioactivity of alkaloids
- Receptor Mechanisms and Signaling
- Biochemical effects in animals
- Bioactive Compounds and Antitumor Agents
- Eicosanoids and Hypertension Pharmacology
- Phenothiazines and Benzothiazines Synthesis and Activities
- Cholinesterase and Neurodegenerative Diseases
- Drug Transport and Resistance Mechanisms
- Phytochemistry and biological activity of medicinal plants
- Chromatography in Natural Products
Shanghai Cancer Institute
2025
Renji Hospital
2025
Shanghai Jiao Tong University
2025
Children's Hospital of Chongqing Medical University
2025
Chongqing Medical University
2025
National Yang Ming Chiao Tung University
2006-2018
Sun Yat-sen University
2013-2018
Sun Yat-sen University Cancer Center
2013-2018
National Yang Ming University Hospital
2004-2014
Taipei City Hospital
2014
Abstract This article reviews the anti-inflammatory relative and anti-infectious effects of Evodia rutaecarpa its major bioactive components involvement nitric oxide synthases, cyclooxygenase, NADPH oxidase, nuclear factor kappa B, hypoxia-inducible 1 alpha, reactive oxygen species, prostaglandins, tumor necrosis factor, LIGHT, amyloid protein orexigenic neuropeptides. Their potential applications for treatment endotoxaemia, obesity, diabetes, Alzheimer's disease their uses as cardiovascular...
The vasoreactivity of dehydroevodiamine (1), evodiamine (2), and rutaecarpine (3), quinazoline alkaloids isolated from Evodia rutaecarpa, to aorta smooth muscle demonstrated that they produce a vasodilatory effect on endothelium-intact rat with equal potency. Compound 3 produced full (100%) nitric oxide-dependent vasodilatation, whereas 2 1 partially endothelium-dependent effect, 50% 10%, respectively. At the same time, I may also act by other mechanisms, including probably an...
This study aimed to explore the mechanisms by which andrographolide protects against hypoxia-induced oxidative/nitrosative brain injury provoked cerebral ischemic/reperfusion (CI/R) in mice. Hypoxia IN VITRO was modeled using oxygen-glucose deprivation (OGD) followed reoxygenation of BV-2 microglial cells. Our results showed that treatment mice have undergone CI/R with (10-100 µg/kg, i. v.) at 1 h after hypoxia ameliorated CI/R-induced stress, infarction, and neurological deficits mice,...
Possible antiinflammatory effects of dehydroevodiamine (1) and evodiamine (2) were examined by assessing their on NO production in the murine macrophage-like cell line RAW 264.7. The results indicated that both 1 2 inhibited IFN-γ/LPS-stimulated a concentration-dependent manner. However, appeared to inhibit interfering not only with priming signal initiated IFN-γ but also iNOS protein synthesis, while affected former only.
Dimemorfan, an antitussive and a sigma-1 (sigma(1)) receptor agonist, has been reported to display neuroprotective properties. We set up animal model of ischemic stroke injury by inducing cerebral ischemia (for 1 h) followed reperfusion 24 (CI/R) in rats examine the protective effects action mechanisms dimemorfan against stroke-induced damage. Treatment with (1.0 microg/kg 10 microg/kg, i.v.) either 15 min before or at time reperfusion, like putative sigma(1) PRE084 (10 i.v.), ameliorated...
Uterine injury can cause uterine scarring, leading to a series of complications that threaten women's health. healing is complex process, and there are currently no effective treatments. Although our previous studies have shown bone marrow mesenchymal stem cells (BMSCs) promote damage repair, the underlying mechanisms remain unclear. However, exploring specific regulatory roles BMSCs in treatment crucial for further understanding their functions enhancing therapeutic efficacy. To investigate...
Diabetes is characterized by chronic hyperglycemia, which in turn facilitates the formation of advanced glycation end products (AGEs). AGEs activate signaling proteins such as Src, Akt and ERK1/2. However, mechanisms these kinases remain unclear. We examined effect on activation 3T3-L1 preadipocytes. Addition to cells activated a dose- time-dependent manner. The AGEs-stimulated was blocked PI3-kinase inhibitor LY 294002, Src PP2, an antioxidant NAC, superoxide scavenger Tiron, or...
Three psychological active principles from the seeds of Peganum harmala L., harmine, harmaline and harmalol, showed vasorelaxant activities in isolated rat thoracic aorta preparations precontracted by phenylephrine or KCl with rank order relaxation potency harmine > harmalol. The effects (but not harmalol) were attenuated endothelium removal pretreatment a nitric oxide (NO) synthase Nomega-nitro-L-arginine methyl ester. In cultured aortic endothelial cells, increased NO release, which was...
In vivo and in vitro studies were carried out to examine the putative hypotensive actions of S-petasin, a sesquiterpene extracted from medicinal plant Petasites formosanus. Intravenous S-petasin (0.1-1.5 mg/kg) anesthetized rats produced dose-dependent effect. isolated aortic ring, isometric contraction elicited by KCl or L-type Ca2+ channel agonist Bay K 8644 was reduced (0.1-100 microM), an action not affected cyclooxygenase inhibitor indomethacin, nitric-oxide synthase...
Lipopolysaccharide (LPS) stimulates peripheral mononuclear cells (PBMC) to synthesize or release pyrogenic cytokines, including interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-alpha (TNF-α). Nuclear factor-kappa B (NF-κB) influences inflammatory responses through the regulation of genes encoding cytokines. In present study, experiments were carried out determine whether an inhibition NF-κB mechanisms causes cytokine synthesis from PBMC results in antipyresis. Intravenous...