A5054817512- Nicotinic Acetylcholine Receptors Study
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Chemical Synthesis and Analysis
- Neuroendocrine regulation and behavior
- Blood Coagulation and Thrombosis Mechanisms
- Cardiac electrophysiology and arrhythmias
- Memory and Neural Mechanisms
- Heart Rate Variability and Autonomic Control
- Peptidase Inhibition and Analysis
- Neuroscience of respiration and sleep
- Neuropeptides and Animal Physiology
- Renin-Angiotensin System Studies
- Insect and Pesticide Research
- Photoreceptor and optogenetics research
- Cannabis and Cannabinoid Research
- Biomedical and Chemical Research
- Stress Responses and Cortisol
- S100 Proteins and Annexins
- Lipid metabolism and disorders
- Cardiac Arrhythmias and Treatments
- Apelin-related biomedical research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Universidad Nacional Autónoma de México
2000-2021
University of Patras
2000-2004
National Hellenic Research Foundation
2000-2004
Agios Andreas Hospital
2004
Onassis Cardiac Surgery Center
2004
University of Craiova
2000
Several behavioral effects of nicotine are mediated by changes in serotonin (5-HT) release brain areas that receive serotonergic afferents from the dorsal raphe nucleus (DRN). In vitro experiments have demonstrated increases firing activity majority DRN 5-HT neurons and contains nicotinic acetylcholine receptors (nAChRs) located at both somata presynaptic elements. One most common is to increase glutamate release. Although receives profuse glutamatergic afferents, effect on has not been...
Abstract Very few neurons in the telencephalon have been shown to express functional postsynaptic nicotinic acetylcholine receptors (nAChRs), among them, noradrenergic and dopaminergic neurons. However, there is no evidence for nAChRs on serotonergic In this study, we asked if are present (5‐HT) nonserotonergic (non‐5‐HT) of dorsal raphe nucleus (DRN). rat midbrain slices, field stimulation at tegmental pedunculopontine (PPT) evoked currents (eEPSCs) with different components DRN After...
Recent studies, have shown that insulin increases extrasynaptic GABAA receptor-mediated currents in the hippocampus, causing alterations of neuronal excitability. The prefrontal cortex (PFC) is another brain area which involved cognition functions and expresses receptors. Here, we used electrophysiological, molecular immunocytochemical techniques to examine effect on tonic slices. We found (20-500 nM) GABAA-mediated currents. Our results suggest promotes trafficking receptors from cytoplasm...
The dorsal raphe nucleus (DRN) contains large populations of serotonergic (5-HT) neurons. This receives GABAergic inhibitory afferents from many brain areas and DRN interneurons. Both 5-HT neurons express functional nicotinic acetylcholine receptors (nAChRs). Previous studies have demonstrated that nicotine increases release neuron discharge rate by stimulating postsynaptic nAChRs increasing glutamate norepinephrine inside DRN. However, the influence on input to was poorly investigated....
The rostromedial tegmental nucleus (RMTg) is a bilateral structure localized in the brainstem and comprise of mainly GABAergic neurons. One main functions RMTg to regulate activity dopamine neurons mesoaccumbens pathway. Therefore, has been proposed as modulator reward system adaptive behaviors associated learning. receives an important glutamatergic input from lateral habenula. Also, it cholinergic inputs laterodorsal pedunculopontine nuclei. Previously, was reported that nicotine increases...
The novel cyclic analogues cyclo(Phe-Leu-Leu-Arg-εLys-Dap) (1) and cyclo(d-Phe-Leu-Leu-Arg-εLys-Dap) (2), which differ only in the absolute conformation of Phe, have been designed synthesized based upon minimal peptide sequence Phe-Leu-Leu-Arg has found to exhibit biological activity for thrombin receptor. Compound 1, all amino acids l-configuration, exhibited higher rat aorta relaxation longitudinal muscle bioassays compared compound 2, Phe residue is d-configuration. This attributed...
The identification of the thrombin receptor has promoted interest for development new therapeutic agents capable selectively inhibiting unwanted biological effects on various cell types. In this study we have designed and synthesized two series antagonists based motif sequence S42FLLR46, one possessing (Phe/Arg) pharmacophoric groups other three (Phe/Arg/NH2). N-(6-Guanidohexanoyl)-N'-(phenylacetyl)piperazine (1), N-(phenylacetyl)-4-(6-guanidohexanoylamidomethyl)piperidine (2),...