A5022011936- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Disaster Response and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Trauma Management and Diagnosis
- Cardiovascular and exercise physiology
- Traumatic Brain Injury and Neurovascular Disturbances
- Hemodynamic Monitoring and Therapy
- Neuroscience of respiration and sleep
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Anesthesia and Pain Management
- Trauma and Emergency Care Studies
- Simulation-Based Education in Healthcare
- Heart Rate Variability and Autonomic Control
- Pericarditis and Cardiac Tamponade
- Ocular Surface and Contact Lens
- Fungal and yeast genetics research
- Corneal Surgery and Treatments
- Primary Care and Health Outcomes
- Non-Invasive Vital Sign Monitoring
- Protein purification and stability
- Traumatic Brain Injury Research
University of Colorado Denver
2018-2024
Children's Hospital Colorado
2018-2024
University of California Davis Medical Center
2023
Children's Hospital of Philadelphia
2023
University of Pennsylvania
2023
Philadelphia University
2023
University of Colorado Anschutz Medical Campus
2020
Los Alamos National Laboratory
2018
National Eye Institute
2015
Nationwide Children's Hospital
2014
Approximately 40% of children who experience an in-hospital cardiac arrest survive to hospital discharge. Achieving threshold intra-arrest diastolic blood pressure (BP) targets during cardiopulmonary resuscitation (CPR) and systolic BP after the return circulation may be associated with improved outcomes.To evaluate effectiveness a bundled intervention comprising physiologically focused CPR training at point care structured clinical event debriefings.A parallel, hybrid stepped-wedge, cluster...
OBJECTIVES: Arterial diastolic blood pressure (DBP) greater than 25 mm Hg in infants and 30 children 1 year old during cardiopulmonary resuscitation (CPR) was associated with survival to hospital discharge one prospective study. We sought validate these potential hemodynamic targets a larger multicenter cohort. DESIGN: Prospective observational SETTING: Eighteen PICUs the ICU-RESUScitation trial from October 2016 March 2020. PATIENTS: Children less or equal 18 years CPR seconds invasive (BP)...
Abstract Background Epinephrine is provided during cardiopulmonary resuscitation (CPR) to increase systemic vascular resistance and generate higher diastolic blood pressure (DBP) improve coronary perfusion attain return of spontaneous circulation (ROSC). The DBP response epinephrine pediatric CPR its association with outcomes have not been well described. Thus, the objective this study was measure between change in after administration ROSC. Methods This a prospective multicenter children...
Supported by laboratory and clinical investigations of adult cardiopulmonary arrest, resuscitation guidelines recommend monitoring end-tidal carbon dioxide (ETCO
OBJECTIVES: To assess associations between outcome and cardiopulmonary resuscitation (CPR) quality for in-hospital cardiac arrest (IHCA) in children with medical cardiac, surgical or noncardiac disease. DESIGN: Secondary analysis of a multicenter cluster randomized trial, the ICU-RESUScitation Project (NCT02837497, 2016–2021). SETTING: Eighteen PICUs. PATIENTS: Children less than equal to 18 years old greater 37 weeks postconceptual age receiving chest compressions (CC) any duration during...
Abstract Introduction Though early hypotension after pediatric in-hospital cardiac arrest (IHCA) is associated with inferior outcomes, ideal post-arrest blood pressure (BP) targets have not been established. We aimed to leverage prospectively collected BP data explore the association of thresholds outcomes. hypothesized that systolic and diastolic would be higher than currently recommended post-cardiopulmonary resuscitation rates survival hospital discharge. Methods performed a secondary...
Abstract Bacteriophage T4 tail fibers are rodlike structures with a contour length of about 1400 Å, diameter 45 and total mass 600,000 daltons. The assembly the their subsequent attachment to phage particle under control 8 phage‐induced proteins. gene molecular weight each protein known. sequence gene‐controlled steps has been determined by characterization intermediates that accumulate when various blocked mutation. composition precursors purification electrophoretic analysis. Four eight...
Ocular chronic graft-versus-host disease is one of the most bothersome common complications following allogeneic hematopoietic stem cell transplantation. The National Institutes Health Chronic Graft-versus-Host Disease Consensus Project provided expert recommendations for diagnosis and organ severity scoring. However, ocular can be diagnosed only after examination by an ophthalmologist. There are no currently accepted definitions activity. goal this study was to identify predictive models...
Quality of cardiopulmonary resuscitation (CPR) is associated with survival, but recommended guidelines are often not met, and less than half the children an in-hospital arrest will survive to discharge. A single-center before-and-after study demonstrated that outcomes may be improved a novel training program in which all pediatric intensive care unit staff encouraged participate frequent CPR refresher regular, structured debriefings focused on patient-centric physiology. This ongoing trial...
OBJECTIVES: Data to support epinephrine dosing intervals during cardiopulmonary resuscitation (CPR) are conflicting. The objective of this study was evaluate the association between and outcomes. We hypothesized that less than 3 minutes would be associated with improved neurologic survival compared greater or equal minutes. DESIGN: This is a secondary analysis ICU-RESUScitation Project (NCT028374497), multicenter trial quality improvement bundle physiology-directed CPR training post-cardiac...
We generated a strain of Saccharomyces cerevisiae in which the sole source α-tubulin protein has cys-to-ser mutation at cys-377, and then we examined microtubule morphology nuclear positioning through cell cycle. During G1 cycle, microtubules C377S (C377S tub1) mutant were indistinguishable from those control (TUB1) strain. However, mitotic C377Stub1 cells displayed astral that often appeared excessive number, abnormally long, and/or misoriented compared with TUB1 cells. Although spindles...
5-Bromouracil (BU)-tolerant mutants of Bacillus subtilis 23 ( thy his ) have been isolated. Several classes tolerant were obtained by a sequential selection procedure. The can be distinguished their relative BU tolerance as well several other phenotypic characteristics. grow for an extended period time in minimal medium supplemented with amino acids and BU, which the sensitive parental strain (Bu + undergoes rapid cell death. Both But-1 But-1310 greater rate deoxyribonucleic acid (DNA)...
In a six-year period (1977-83), lesions were identified by enteroclysis in 26 patients with melena or recurrent gastrointestinal bleeding undiagnosed other modalities. These included nine Meckel's diverticula, three metastatic lesions, primary carcinomas, one lipoma, four leiomyomas, five surgically created blind pouches, carcinoid, and idiopathic dilatation of the ileum. Our experience suggests that, when standard diagnostic procedures used to investigate chronic blood loss are unrevealing,...
OBJECTIVES: Cannulation for extracorporeal membrane oxygenation during active cardiopulmonary resuscitation (ECPR) is a method to rescue patients refractory standard resuscitation. We hypothesized that early arrest hemodynamics and end-tidal C o 2 (ET co ) are associated with survival hospital discharge favorable neurologic outcome in pediatric ECPR patients. DESIGN: Preplanned, secondary analysis of Utstein, hemodynamic, ventilatory data collected the 2016–2021 Improving Outcomes from...
Tracheal intubation (TI)-associated cardiac arrest (TI-CA) occurs in 1.7% of pediatric ICU TIs. Our objective was to evaluate resuscitation characteristics and outcomes between patients with without TI-CA.
High-quality cardiopulmonary resuscitation is associated with improved survival and neurological outcomes after cardiac arrest. Unfortunately, health care professionals frequently do not perform within guidelines life-support training.To determine if brief intermittent training in could improve nurses' skills to high-quality 70% or more of the time during 2 minutes 3 sessions.In a prospective single-center quality improvement program, pediatric critical nurses had monthly resuscitation. A...
Objectives: The COVID-19 pandemic resulted in adaptations to pediatric resuscitation systems of care. objective this study was determine the temporal association between and in-hospital cardiac arrest (IHCA) process care metrics, cardiopulmonary (cardiopulmonary resuscitation) quality, patient outcomes. Design: Multicenter retrospective analysis a dataset comprising observations IHCA outcomes pre (March 1, 2019 February 29, 2020) versus 2020 28, 2021). Setting: Data source ICU-RESUScitation...