A5007067836- Gastroesophageal reflux and treatments
- Esophageal and GI Pathology
- Nutritional Studies and Diet
- Folate and B Vitamins Research
- Eosinophilic Disorders and Syndromes
- Autoimmune Bullous Skin Diseases
- Alcohol Consumption and Health Effects
- Nutrition and Health in Aging
- Skin Diseases and Diabetes
- Esophageal Cancer Research and Treatment
- Eosinophilic Esophagitis
- Advanced Manufacturing and Logistics Optimization
- Mast cells and histamine
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Plant Pathogens and Fungal Diseases
- Nutrition, Genetics, and Disease
- Obesity and Health Practices
- Geophysics and Sensor Technology
- Medicinal Plants and Neuroprotection
- Dermatologic Treatments and Research
- Blood Coagulation and Thrombosis Mechanisms
- Dysphagia Assessment and Management
- Diverticular Disease and Complications
- Vitamin D Research Studies
- Cancer Diagnosis and Treatment
Kishokai Medical Corporation
2024
Shizuoka City Shimizu Hospital
2021-2022
Nagoya University of Arts and Sciences
2017
Keio University
1966-2016
The genetic polymorphisms of aldehyde dehydrogenase-2 ( ALDH2 ), alcohol dehydrogenase-1B ADH1B , previously called ADH2 and ADH1C (previously ADH3 ) affect the metabolism alcohol. inactive encoded by ALDH2*1/*2 less-active ADH1B*1/*1 increase risk esophageal squamous cell carcinoma in East Asian drinkers. This case–control study involved 96 Japanese men with oral pharyngeal (hypopharyngeal cancer 43 patients oral/oropharyngeal 53) 642 cancer-free men. cancers overall hypopharyngeal was...
Because few Japanese questionnaires assess the elderly's appetite, there is an urgent need to develop appetite questionnaire with verified reliability, validity, and reproducibility.We translated back-translated Council on Nutrition Appetite Questionnaire (CNAQ), which has eight items, into (CNAQ-J), as well Simplified Nutritional (SNAQ-J), includes four CNAQ-J-derived items. Using structural equation modeling, we examined CNAQ-J structure based data of 649 elderly people in 2013, including...
A strong association between inactive aldehyde dehydrogenase-2 (ALDH2) and risk of esophageal cancer has been demonstrated in East Asian drinkers. An alcohol flushing questionnaire asking about past current tendency for facial to occur after drinking a glass (≈180 mL) beer predicts the presence ALDH2 among Japanese aged 40 years or older with sensitivity specificity approximately 90%. We invented health-risk appraisal (HRA) model that makes it possible identify men who are at high based on...
In order to fortify bone mineral density (BMD), and prevent osteoporosis in the future, we investigated consumption of BMD-associated nutrients, their food sources pre-school Japanese children. Intakes minerals (calcium, magnesium, phosphorus) vitamins (vitamin D, vitamin K, C) were studied based on two weekdays dietary record surveys together with photos taken by 84 parents/caregivers 5-year-old Food relevant nutrients identified according contribution analyses, potential associations...
Mast cells and inflammatory are abundant in keloid hypertrophic scar tissues. Even if the cause of physical injury is similar, such as piercing or scratching with hands, clinical findings show differences size keloids same area. Hence, we performed histological studies on giant larger than earlobe, other smaller keloids. We also examined risk factors associated formation lesions. No statistically significant association were observed. However, observations clearly showed a high number...
This study aimed to clarify the influence of dietary habits and daily intake fermented milk product containing Bifidobacterium breve strain Yakult, 1．0 × 1010 cfu/100 mL/day on bowel in healthy young Japanese women. To interaction a mL/day, food A total 150 female university students participated this study. They recorded amount using food-frequency questionnaire （FFQ） during pre-experiment period diary After exclusion 30 subjects who defecated every day, 120 were randomly divided two...
Objective: We studied effects of fermented milk fortified with 200 μg folic acid (FF milk) on serum folate levels in Japanese women university students. Methods: Adopting FF as intervention factor, a randomized controlled trial stratified by MTHFR genetic polymorphism C677T was conducted 143 students. Experimental group subjects were requested to consume for 4 weeks; control usual meals. Dietary surveys using an FFQ, and concentrations analyzed utilizing chemiluminescence immunoassay. Using...
Omalizumab is a recombinant humanized monoclonal anti-IgE antibody used to treat uncontrolled chronic spontaneous urticaria (CSU). Sometimes patients with CSU also have other autoimmune conditions. Recent studies demonstrated the safety and efficacy of combination treatment omalizumab biologics. Here, we report first successful for tocilizumab rheumatoid arthritis. Since unlikely cause severe immunosuppression, it may be option CSU, even in treated
Folate is important for prevention of neural tube defects (NTDs). We studied the associations knowledge folate and NTDs with intake folate, food consumption structure in female university students, including newcomers senior students (juniors plus seniors). Of these, had insufficient NTDs. No were observed between their acquaintance all students. Food analyses revealed that consuming more than Recommended Dietary Allowance not only folate-contributing but also a variety items. Thus, it was...
尿路感染症および上気道炎を契機にDICが出現し, 急性腎不全と, 原因不明の低血糖発作に伴う昏睡状態を合併した患者に遭遇し, 血液透析療法により, 救命しえた症例を報告する. 症例は48歳, 女性. 尿路感染症, 敗血症を契機に, 急性腎不全に陥り, さらに低血糖発作に伴う昏睡状態にて入院となった. 本症例はDICの重要な指標であるフィブリン分解産物 (FDP) は, ラテックス凝集法では陰性であった. 従って, DICスコアは5点であり, 一般検査ではDICとは判定不可能であった. 詳細な凝固に関する検査の結果, 凝固系パラメータは高値を示し, 線溶系パラメータは不変であった. さらに血漿中のplasminogen activator inhibitor-1 (PAI-1) が高値 (148ng/ml) を示していた. イムノブロッティング法により, 活性化高分子キニノゲン (kinin-free high molecular weight kininogen; HKa) が多く認められ, 接触因子系凝固因子の活性化ならびにブラディキニンの放出が認められた....