A5015362709- Mosquito-borne diseases and control
- Malaria Research and Control
- COVID-19 epidemiological studies
- Travel-related health issues
- Viral Infections and Vectors
- vaccines and immunoinformatics approaches
- HIV Research and Treatment
- Species Distribution and Climate Change
- Immune responses and vaccinations
- Public Health and Nutrition
- Global Maternal and Child Health
- Advanced Database Systems and Queries
Research Institute for Tropical Medicine
2018-2023
Department of Health
2020
Identifying fine-scale spatial patterns of disease is essential for effective control and elimination programmes. In low resource areas without formal addresses, novel strategies are needed to locate residences individuals attending health facilities in order efficiently map patterns. We aimed assess the use Android tablet-based applications containing high resolution maps geolocate individual residences, whilst comparing functionality, usability cost three software packages designed collect...
BackgroundAssessing the status of malaria transmission in endemic areas becomes increasingly challenging as countries approach elimination. Serology can provide robust estimates intensities, and multiplex serological assays allow for simultaneous assessment markers recent historical exposure.MethodsHere, we evaluated different statistical machine learning methods analyzing malaria-specific antibody response data to classify exposure Plasmodium falciparum vivax. To assess these methods,...
Following substantial progress in malaria control the Philippines, new surveillance approaches are needed to identify and target residual transmission. This study evaluated an enhanced approach using rolling cross-sectional surveys of all health facility attendees augmented with molecular diagnostics geolocation. Facility were carried out three sites representing different transmission intensities: Morong, Bataan (pre-elimination), Abra de Ilog, Occidental Mindoro (stable medium risk),...
Background Antimalarial antibody measurements are useful because they reflect historical and recent exposure to malaria. As such, may provide additional information assess ongoing transmission in low endemic or pre-elimination settings where cases rare. In addition, the absence of responses certain individuals can indicate cessation transmission. Commercial malaria enzyme-linked immunosorbent assays (ELISA) detect antimalarial antibodies commonly used screen blood donations for possible...
Objectives: The Department of Health (DOH) aims to reduce the prevalence intestinal parasitism and proportion heavy intensity infection in country by 2022. Among interventions is school-based mass drug administration (MDA). Regular assessment MDA gives guidance DOH. aim this survey was determine soil transmitted helminthiasis histosomiasis among public school children ages 5 16 years old. Methodology: A cross-sectional, study using multi-stage stratified cluster sampling conducted from 2013...
Abstract Following substantial progress in malaria control the Philippines, new surveillance approaches are needed to identify and target residual transmission. This study evaluated an enhanced approach using rolling cross-sectional surveys of all health facility attendees augmented with molecular diagnostics geolocation. Facility were carried out 3 sites representing different transmission intensities: Morong, Bataan (pre-elimination), Abra de Ilog, Occidental Mindoro (stable-medium risk)...
Abstract Background Assessing the status of malaria transmission in endemic areas becomes increasingly challenging as countries approach elimination. Serology can provide robust estimates intensities, and multiplex serological assays allow for simultaneous assessment markers recent historical exposure. Methods Here, we evaluated different statistical machine learning methods analyzing malaria-specific antibody response data to classify exposure Plasmodium falciparum P. vivax . To assess...
This study provides 2016 data on the prevalence of key single nucleotide polymorphisms (SNPs) associated with antimalarial drug resistance in Palawan, Philippines. Findings were combined historical to model temporal changes these SNPs Plasmodium isolates.Plasmodium isolates genotyped using markers pfmdr1, pfcrt, pfdhfr, pfdhps, kelch-13, pvmdr1, pvdhfr, and pvdhps. Temporal trends probability mutations estimated as a function time binomial generalised linear model.All samples sequenced for...
Abstract Landscape changes have complex effects on malaria transmission, disrupting social and ecological systems determining the spatial distribution of risk. Within Southeast Asia, forested landscapes are associated with both increased transmission reduced healthcare access. Here, we adapt an modelling framework to identify how local environmental factors influence distributions infections, diagnostic sensitivity detection probabilities in Philippines. Using convenience sampling health...
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