A5100363126- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Ubiquitin and proteasome pathways
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Cancer Immunotherapy and Biomarkers
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Peptidase Inhibition and Analysis
- Gastric Cancer Management and Outcomes
- Cancer Mechanisms and Therapy
- MicroRNA in disease regulation
- Lung Cancer Treatments and Mutations
- Cancer-related Molecular Pathways
- Heme Oxygenase-1 and Carbon Monoxide
- PI3K/AKT/mTOR signaling in cancer
- Chronic Myeloid Leukemia Treatments
- Trace Elements in Health
- RNA Research and Splicing
- Birth, Development, and Health
- Chronic Lymphocytic Leukemia Research
- Renal cell carcinoma treatment
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Treatments and Studies
Institute of Hematology & Blood Diseases Hospital
2017-2025
Tongji Hospital
2015-2025
Huazhong University of Science and Technology
2015-2025
Chengdu Third People's Hospital
2025
Sichuan University
2006-2025
Fujian Medical University
2001-2025
First Affiliated Hospital of Fujian Medical University
2022-2025
Pudong New Area People's Hospital
2025
Zhejiang Yongning Pharma (China)
2020-2025
Affiliated Hospital of North Sichuan Medical College
2023-2025
Ferroptosis is a type of iron-dependent regulated cell death characterized by unrestricted lipid peroxidation and membrane damage. Although GPX4 (glutathione peroxidase 4) plays master role in blocking ferroptosis eliminating phospholipid hydroperoxides, the regulation remains poorly understood. Here, we report an unexpected for copper promoting ferroptotic death, but not cuproptosis, inducing macroautophagic/autophagic degradation GPX4. Copper chelators reduce sensitivity do inhibit other...
Macroautophagy (hereafter referred to as "autophagy") is a lysosome-mediated degradation process that plays complex role in cellular stress, either promoting survival or triggering death. Early studies suggest ferroptosis, an iron-dependent form of regulated cell death, not related autophagy. Conversely, recent evidence indicates the molecular machinery autophagy facilitates ferroptosis through selective anti-ferroptosis regulators. However, mechanism autophagy-dependent remains incompletely...
Although induction of ferroptosis, an iron-dependent form non-apoptotic cell death, has emerged as anticancer strategy, the metabolic basis ferroptotic death remains poorly elucidated. Here, we show that glucose determines sensitivity human pancreatic ductal carcinoma cells to ferroptosis induced by pharmacologically inhibiting system xc−. Mechanistically, SLC2A1-mediated uptake promotes glycolysis and, thus, facilitates pyruvate oxidation, fuels tricyclic acid cycle, and stimulates fatty...
Lipid peroxidation-dependent ferroptosis has become an emerging strategy for tumor therapy. However, current strategies not only selectively induce in malignant cells but also trigger immune simultaneously, which can compromise anti-tumor immunity. Here, we used In-Cell Western assays combined with unbiased drug screening to identify the compound N6F11 as a inducer that triggered degradation of glutathione peroxidase 4 (GPX4), key repressor, specifically cancer cells. did cause GPX4 cells,...
Selective macroautophagy/autophagy maintains cellular homeostasis through the lysosomal degradation of specific proteins or organelles. The pro-survival effect selective autophagy has been well-characterized, but mechanism by which it drives cell death is still poorly understood. Here, we use a quantitative proteomic approach to identify HPCAL1 (hippocalcin like 1) as novel receptor for CDH2 (cadherin 2) during ferroptosis. HPCAL1-dependent depletion increases susceptibility ferroptotic...
Abstract Ferroptosis is a type of lipid peroxidation-dependent cell death that emerging as therapeutic target for cancer. However, the mechanisms ferroptosis during generation and detoxification peroxidation products remain rather poorly defined. Here, we report an unexpected role eukaryotic translation initiation factor EIF4E determinant ferroptotic sensitivity by controlling peroxidation. A drug screening identified 4EGI-1 4E1RCat (previously known EIF4E-EIF4G1 interaction inhibitors)...