A5052821026- Porphyrin and Phthalocyanine Chemistry
- Metal-Catalyzed Oxygenation Mechanisms
- Mycorrhizal Fungi and Plant Interactions
- Plant-Microbe Interactions and Immunity
- Plant Pathogens and Fungal Diseases
- Photosynthetic Processes and Mechanisms
- HIV Research and Treatment
- Inorganic and Organometallic Chemistry
- HIV/AIDS drug development and treatment
- Genomics and Phylogenetic Studies
- Chemical Reaction Mechanisms
- Synthesis and Characterization of Heterocyclic Compounds
- Bioenergy crop production and management
- Synthesis and biological activity
- Organic Chemistry Cycloaddition Reactions
- Magnetism in coordination complexes
- Plant and Fungal Species Descriptions
- Gene expression and cancer classification
- Porphyrin Metabolism and Disorders
- Electrocatalysts for Energy Conversion
- Surface Chemistry and Catalysis
- Seaweed-derived Bioactive Compounds
- Metalloenzymes and iron-sulfur proteins
- Radical Photochemical Reactions
- Synthesis and Biological Evaluation
McGill Genome Centre
2022-2025
McGill University
2022-2025
Centre For Human Genetics
2024
Université de Montréal
2006-2022
University of Arizona
2021
McGill University and Génome Québec Innovation Centre
2018-2019
Ontario Genomics
2018-2019
Instituto Nacional de Neurología y Neurocirugía
2019
Universidad Tecnológica de Panamá
2018
Florida International University
2012
With the decreasing cost of sequencing and rapid developments in genomics technologies protocols, need for validated bioinformatics software that enables efficient large-scale data processing is growing.Here we present GenPipes, a flexible Python-based framework facilitates development deployment multi-step workflows optimized high-performance computing clusters cloud. GenPipes already implements 12 scalable pipelines various applications, including RNA sequencing, chromatin...
One method for rejuvenating land polluted with anthropogenic contaminants is through phytoremediation, the reclamation of cultivation specific crops. The capacity phytoremediation crops, such as Salix spp., to tolerate and even flourish in contaminated soils relies on a highly complex predominantly cryptic interacting community microbial life. Here, Illumina HiSeq 2500 sequencing de novo transcriptome assembly were used observe gene expression washed purpurea cv. 'Fish Creek' roots from...
X-ray crystallographic analyses of two sterically unhindered copper meso-triarylcorroles, Cu[5,15-P2-10-(4-MeOP)C] and Cu[5,15-(4-CF3P)2-10-(4-MeOP)C] (P = phenyl C corrole), revealed substantially saddled corrole rings. These results are in marked contrast to those on highly hindered cobalt(III) iridium(III) corroles, which exhibit planar macrocycles. The solution this conundrum is that corroles inherently saddled, as a result specific copper(d)−corrole(π) orbital interaction. This...
The D7 subfamily of salivary proteins is widespread in blood sucking Diptera and belongs to the superfamily pheromone/odourant binding proteins. Although are among most abundant adult female mosquitoes sand flies, their role feeding remains elusive. In present work we report sequence seventeen novel proteins, propose an evolutionary scenario for appearance several forms this protein, based on a total twenty-one sequences from Culex quinquefasciatus, Aedes aegypti, Anopheles gambiae, An....
Density functional theory (DFT) calculations have been carried out for a variety of iron and manganese porphyrin complexes with metal oxidation states +3 above. In general, DFT gives very good descriptions molecular structure electron distributions, but appears less reliable in predictions the relative energetics different spin transition compounds. For instance, fact that our favor quartet state five-coordinate complex, ( P ) FeCl , over sextet may be regarded as shortcoming currently...
Willows can alleviate soil salinisation while generating sustainable feedstock for biorefinery, yet the metabolomic adaptations underlying their tolerance remain poorly understood. Salix miyabeana was treated with two environmentally abundant salts, NaCl and Na2SO4, in a 12-week pot trial. tolerated salts across all treatments (up to 9.1 dS m-1 ECe), maintaining biomass selectively partitioning ions, confining Na+ roots accumulating Cl- SO42-$$ {\mathrm{SO}}_4^{2-} $$ canopy adapting osmotic...
Low-basicity pyridines and other strong π-acceptors as axial ligands in six-coordinate iron(III) porphyrins (ferrihemes) result a (dxz,dyz)4(dxy)1 configuration of the center opposed to usual (dxz,dyz)3(dxy)2 configuration. Density functional calculations have been used characterize visualize these variable electron distributions. For configuration, porphyrin ligand is strongly noninnocent has significant a2u-type cation radical character due dxy−"a2u" interactions. These orbital overlaps...
Abstract Les déplacements chimiques du 13 C de trente‐deux pyrazoles ont été mesurés dans le diméthylsulfoxyde hexadeutérié et l'hexaméthylphosphorotriamide. Nous avons déterminé l'influence respective des différents substituants par régression multilinéaire (substitutions un méthyle amino sur les carbones l'hétérocycle, méthyle, n ‐butyle phényle l'azote). Le problème la détermination constantes d'équilibre tautomère, à partir résultats RMN est discuté illustré avec cas amino‐3(5) pyrazoles.
High-throughput RNA sequencing studies are becoming increasingly popular and differential expression represent an important downstream analysis that often follow de novo transcriptome assembly. If a lot of attention has been given to bioinformatics tools for gene expression, little yet the impact sequence data itself used in pipelines.We tested how using different types reads from ones assemble (both differing length pairing attributes) could potentially affect (DE) results. To investigate...
High concentrations of petroleum hydrocarbon (PHC) pollution can be hazardous to human health and leave soils incapable supporting agricultural crops. A cheap solution, which help restore biodiversity bring land back productivity, is cultivation high biomass yielding willow trees. However, the genetic mechanisms allow these fast-growing trees tolerate PHCs are as yet unclear. Salix purpurea 'Fish Creek' were pot-grown in soil from a former refinery, either lacking or enriched with C10-C50...
Abstract Après avoir établi la structure des dérivés N ‐méthylés par voie univoque, on examine réactivité d'un dérivé du pyrazolo[3,4‐ d ]‐ v ‐triazole vis‐à‐vis de differents agents méthylation. On propose une pour les NNO et NCOR.
The reaction of PhBCl2 with free base triarylcorroles results in a spontaneous reduction to give diboron corrole complexes (PhBHBPh)(Cor) which proton has been captured form bridging B–H–B group encapsulated within the ligand. proposed mechanism is supported by PhBF2 H3Cor (PhBF)(BPh)(Cor) no occurred.
Metatranscriptomic study of nonmodel organisms requires strategies that retain the highly resolved genetic information generated from model while allowing for identification unexpected. A real-world biological application phytoremediation, field growth 10 Salix cultivars on polluted soils, was used as an exemplar and multifaceted crop response well-disposed to gene expression. Sequence reads were assembled de novo create independent transcriptomes, a global transcriptome, mapped against...
Abstract We present here a relatively comprehensive theoretical study, based on nonlocal density functional theory calculations, of the energetics, electron distributions, and structural features low‐lying electronic states various high‐valent intermediates manganese porphyrins. Two classes molecules have been examined: (a) compounds with general formula [(P)MnX 2 ] 0 (P = porphyrin; X F, Cl, PF 6 ) (b) manganese‐oxo species. For [(P)Mn(PF , calculations reveal number nearly equienergetic...
DFT calculations, using the PW91, OLYP, and B3LYP functionals, have provided some of first estimates relative energies Ni(I) Ni(II) ligand anion radical states hydroporphyrin complexes. Although three functionals chosen sometimes yield discordant results, results this study are essentially functional-independent. For isobacteriochlorin derivatives, our calculations predict that state may be favored by 0.5 eV or more, to state. other hydroporphyrins, however, electrochemical studies indicate...
Virus-inhibitory peptide (VIRIP) has been identified as a component of human hemofiltrate that blocks HIV-1 gp41-dependent fusion by interacting with the peptide. A VIRIP analogue (VIR-576) shown to be effective in phase I/II clinical trial. We have evaluated activity and mechanism resistance its analogue, VIR-353.Anti-HIV passage strains cell culture were used generate identify mutations confer VIR-353. Recombinant viruses harboring most relevant generated characterized.VIRIP VIR-353 showed...
Identification of CCR5 as an antiretroviral target led to the development several antagonists in clinical trials and approval maraviroc. Evaluating mechanism drug resistance agents may have implications this class agents. We analysed profile two R5 HIV-1 strains [BaL a isolate (CI)] after long-term passage cell culture presence TAK-779, first developed non-peptidic small molecule targeting CCR5.Genotypic phenotypic tests were used evaluate virus isolated from inhibitor TAK-779.Mutations...
Trigonal-planar, middle transition metal diiminato-imido complexes do not exhibit high-spin states, as might be naively expected on the basis of their low coordination numbers. Instead, known Fe(III), Co(III), and Ni(III) S = 3/2, 0, 1/2 ground respectively. Kohn-Sham DFT calculations have provided a basic molecular orbital picture these compounds well qualitative rationale for observed spin states. Reported herein are ab initio multiconfiguration second-order perturbation theory (CASPT2)...