A5021418972- Epigenetics and DNA Methylation
- HIV Research and Treatment
- RNA modifications and cancer
- Mosquito-borne diseases and control
- Genetics and Neurodevelopmental Disorders
- HIV-related health complications and treatments
- Insect symbiosis and bacterial influences
- NF-κB Signaling Pathways
- Cancer-related gene regulation
- thermodynamics and calorimetric analyses
- Synthesis and biological activity
- Inorganic and Organometallic Chemistry
- Bioactive Compounds and Antitumor Agents
Institut Pasteur
2022-2025
Université Paris Cité
2022
Centre National de la Recherche Scientifique
2022
DNA methylation modulates gene expression without altering the sequence. Aberrant patterns characterise a wide range of diseases, from cancer to neurological disorders, and serve as validated therapeutic targets diagnostic tools. Among proteins involved in regulation, human reader Methyl‐CpG Binding Domain 2 protein (MBD2) exhibits strong preference for methylated initiates signalling cascades predominantly resulting repression. The full description this mechanism is still be elucidated....
DNA methylation modulates gene expression without altering the sequence. Aberrant patterns characterise a wide range of diseases, from cancer to neurological disorders, and serve as validated therapeutic targets diagnostic tools. Among proteins involved in regulation, human reader Methyl‐CpG Binding Domain 2 protein (MBD2) exhibits strong preference for methylated initiates signalling cascades predominantly resulting repression. The full description this mechanism is still be elucidated....
Compound <bold>4</bold>, derived from IMD-0354, blocks the canonical NF-κB pathway although it is inactive on IKKβ enzyme.
DNA methylation is a well-known epigenetic modification that modulates gene expression without altering the sequence of genome. Aberrant patterns characterize wide range diseases, from cancer to neurological disorders, and serve as both validated therapeutic targets diagnostic tools. Among proteins involved in regulation are reader (MBPs), which bind methylated initiate signalling cascade involving different protein complexes, predominantly resulting repression, thereby playing significant...
Epigenetics has received much attention in the past decade. Many insights on epigenetic (dys)regulation diseases have been obtained, and clinical therapies targeting them are place. However, readers of marks lacking enlightenment behind this revolution, it is poorly understood how DNA methylation being read translated to chromatin function cellular responses. Chemical probes methyl-CpG readers, such as binding domain proteins (MBDs), could be used study mechanism. We designed analogues...