A5037457244- Fibroblast Growth Factor Research
- Galectins and Cancer Biology
- Proteoglycans and glycosaminoglycans research
- Glycosylation and Glycoproteins Research
- Wnt/β-catenin signaling in development and cancer
- Kruppel-like factors research
- Monoclonal and Polyclonal Antibodies Research
- Polysaccharides and Plant Cell Walls
- Protein Tyrosine Phosphatases
- Toxin Mechanisms and Immunotoxins
- Neuroendocrine Tumor Research Advances
- Ubiquitin and proteasome pathways
- Biochemical and Structural Characterization
- Connective tissue disorders research
- Epigenetics and DNA Methylation
- Peptidase Inhibition and Analysis
- Cellular transport and secretion
University of Wrocław
2020-2024
Fibroblast growth factor receptor 1 (FGFR1) is a N-glycosylated cell surface tyrosine kinase, which upon recognition of specific extracellular ligands, fibroblast factors (FGFs), initiates an intracellular signaling. FGFR1 signaling ensures homeostasis cells by fine-tuning essential cellular processes, like differentiation, division, motility and death. activity coordinated at multiple steps unbalanced contributes to developmental diseases cancers. One the crucial control mechanisms over...
FGF/FGFR signaling is critical for the development and homeostasis of human body imbalanced contributes to progression severe diseases, including cancers. FGFRs are N-glycosylated, but role these modifications largely unknown. Galectins extracellular carbohydrate-binding proteins implicated in a plethora processes heathy malignant cells. Here, we identified precise set galectins (galectin-1, -3, -7, -8) that directly interact with N-glycans FGFRs. We demonstrated bind N-glycan chains...
Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabolism, and death. Overexpression of FGFR1 is observed in numerous tumors thus constitutes an attractive molecular target for selective cancer treatment. Targeted anti-cancer therapies aim precise delivery drugs into cells, sparing healthy ones limiting unwanted side effects. One key steps targeted drug receptor-mediated endocytosis....
Antibody drug conjugates (ADCs) represent one of the most promising approaches in current immuno-oncology research. The precise delivery cytotoxic drugs to cancer cells using ADCs specific for tumor-associated antigens enables sparing healthy and thereby reduces unwanted side effects. Overexpression fibroblast growth factor receptor 1 (FGFR1) has been demonstrated numerous tumors constitutes a convenient molecular target selective treatment. We have recently engineered tetravalent anti-FGFR1...
Abstract Fibroblast growth factors (FGFs) and their receptors (FGFRs) constitute complex signaling hubs that are crucial for the development homeostasis of human body. Most FGFs released by cells using conventional secretory pathway N-glycosylated, yet role glycosylation is largely unknown. Here, we identify N-glycans as binding sites a specific set extracellular lectins, galectins − 1, -3, -7 8. We demonstrate attract N-glycosylated FGF4 to cell surface, forming reservoir factor in matrix....
Fibroblast growth factor receptors (FGFRs) are integral membrane proteins involved in various biological processes including proliferation, migration and apoptosis. There a number of regulatory mechanisms FGFR signaling, which tightly control the specificity duration transmitted signals. The effect FGFRs spatial distribution plasma on receptor-dependent functions is still largely unknown. We have demonstrated that oligomerization FGF1 with coiled-coil motifs improves affinity for heparin....
Overexpression of FGFR1 is observed in numerous tumors and therefore this receptor constitutes an attractive molecular target for selective cancer treatment with cytotoxic conjugates. The success therapy conjugates largely relies on the precise recognition a cancer-specific marker by targeting molecule within conjugate its subsequent cellular internalization mediated endocytosis. We have recently demonstrated that efficiency mechanism are governed spatial distribution plasma membrane, where...
Fibroblast growth factor receptor 1 (FGFR1) is an integral membrane protein that transmits prolife signals through the plasma membrane. Overexpression of FGFR1 has been reported in various tumor types, and therefore, this constitutes attractive molecular target for selective anticancer therapies. Here, we present a novel system generation intrinsically fluorescent, self-assembling, oligomeric cytotoxic conjugates with high affinity efficient internalization targeting FGFR1. In our approach,...
FGFRs are cell surface receptors that, when activated by specific FGFs ligands, transmit signals through the plasma membrane, regulating key cellular processes such as differentiation, division, motility, metabolism and death. We have recently shown that modulation of spatial distribution FGFR1 at constitutes an additional mechanism for fine-tuning signaling. Depending on multivalent, engineered ligand used, clustering into diverse supramolecular complexes enhances efficiency modifies...
Precise anticancer therapies employing cytotoxic conjugates constitute a side-effect-limited, highly attractive alternative to commonly used cancer treatment modalities, such as conventional chemotherapy, radiotherapy or surgical interventions. Receptor tyrosine kinases are large family of N-glycoproteins intensively studied molecular targets for in various cancers. At the cell surface, these receptors embedded dense carbohydrate layer formed by numerous plasma membrane glycoproteins. The...
Cancer is currently the second most common cause of death worldwide. The hallmark cancer cells presence specific marker proteins such as growth factor receptors on their surface. This feature enables development highly selective therapeutics, protein bioconjugates, composed targeting (antibodies or receptor ligands) connected to cytotoxic drugs by a linker. Due very high affinity and selectivity bioconjugates recognize surface utilize receptor-mediated endocytosis reach cell interior....
Cancer is currently the second most common cause of death worldwide. The hallmark cancer cells presence specific marker proteins such as growth factor receptors on their surface. This feature enables development highly selective therapeutics, protein bioconjugates, composed targeting (antibodies or receptor ligands) connected to cytotoxic drugs by a linker. Due very high affinity and selectivity bioconjugates recognize surface utilize receptor-mediated endocytosis reach cell interior....