A5017420881- Vitamin C and Antioxidants Research
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Inflammasome and immune disorders
- Antioxidant Activity and Oxidative Stress
- Influenza Virus Research Studies
- Retinoids in leukemia and cellular processes
- Ovarian function and disorders
- Autophagy in Disease and Therapy
- Cancer Research and Treatments
- Reproductive Biology and Fertility
- Phagocytosis and Immune Regulation
- Monoclonal and Polyclonal Antibodies Research
- Gut microbiota and health
- Reproductive System and Pregnancy
- MicroRNA in disease regulation
- Cardiac electrophysiology and arrhythmias
Taconic (United States)
2024
Providence College
2015-2022
EpiVax (United States)
2022
Brown University
2018-2020
John Brown University
2018
Rhode Island Hospital
2015
Background In a prior report, we detailed the isolation and engineering of bispecific killer cell engager, referred to as BiKE:E5C1. The BiKE:E5C1 exhibits high affinity/specificity for CD16a activating receptor on natural (NK) cells human epidermal growth factor 2 (HER2) cancer cells. vitro studies have demonstrated that can activate NK induce killing HER2+ ovarian breast cells, surpassing performance best-in-class monoclonal antibody, Trazimera (trastuzumab). To advance this BiKE...
Intestinal epithelial cells (IECs) are at the forefront of host-pathogen interactions, coordinating a cascade immune responses to protect against pathogens. Here we show that IEC-intrinsic vitamin A signaling restricts pathogen invasion early in infection and subsequently activates promote clearance. Mice blocked for retinoic acid receptor (RAR) selectively IECs (stopΔIEC) showed higher Salmonella burden colonic tissues associated with luminal systemic loads later stages. Higher stopΔIEC...
Infertility is a devastating condition affecting one in six people globally. In many cases, the underlying causes are unknown. Emerging evidence suggests that microbiota influences reproduction, yet mechanistic link between microbiota, ovarian function, and length of fertile lifespan remain unexplored. Here we report controls reproductive by maintaining primordial follicle pool, process mediated microbiota-derived short chain fatty acids modulating gene regulatory networks crucial for...
Abstract Antimicrobials secreted by the intestinal epithelium are critical for regulating host-microbe interactions in gut. However, certain pathogens can exploit excessive antimicrobial response during infection to outcompete commensal bacteria. We have uncovered a novel epithelial cell intrinsic mechanism which bacteria modulate Interleukin (IL)-22 induced antimicrobials provide colonization resistance against pathogens. Vitamin A metabolite, retinoic acid (RA), is coordinating multiple...
Abstract Intestinal epithelial cells (IECs) are at the forefront of host-pathogen interactions, coordinating a cascade immune responses to confer protection against pathogens. Here we show that IEC-intrinsic vitamin A signaling restricts pathogen invasion early in infection and subsequently activates promote clearance. Mice blocked for retinoic acid receptor (RAR) selectively IECs (stop ΔIEC ) showed significantly higher Salmonella burden colonic tissues associated with luminal systemic...
Strategies that improve influenza vaccine immunogenicity are critical for the development of vaccines pandemic preparedness. Hemagglutinin (HA)-specific CD4+ T cell epitopes support protective B responses against seasonal influenza. However, in case avian H7N9, which poses a threat, HA elicits only weak neutralizing antibody infection and vaccination without adjuvant. We hypothesized an immune-engineered H7N9 incorporating broadly reactive H3N2 HA-specific memory epitope replaces regulatory...