A5103170974- Library Collection Development and Digital Resources
- Pancreatic function and diabetes
- Weed Control and Herbicide Applications
- Neuroendocrine Tumor Research Advances
- Library Science and Information Systems
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Trauma and Emergency Care Studies
- Pesticide and Herbicide Environmental Studies
- Cardiac Arrest and Resuscitation
- Information Retrieval and Search Behavior
- Metabolism, Diabetes, and Cancer
- Plant tissue culture and regeneration
- Mathematics, Computing, and Information Processing
- Allelopathy and phytotoxic interactions
- Digital and Traditional Archives Management
- Astrophysics and Cosmic Phenomena
- Distributed and Parallel Computing Systems
- Research Data Management Practices
- Digital Humanities and Scholarship
- Peripheral Artery Disease Management
- Aortic aneurysm repair treatments
- Trauma Management and Diagnosis
- Semantic Web and Ontologies
- Diabetes Treatment and Management
- Vascular Procedures and Complications
University of Illinois Urbana-Champaign
1995-2019
Baylor College of Medicine
2004-2016
American Association for the Surgery of Trauma
2013-2016
Plano Cancer Institute
2016
University of California, San Diego
2015
Ben Taub Hospital
2009-2012
Emory University
2006-2009
Monterey Bay Aquarium Foundation
2009
Memorial Regional Hospital
2009
Baylor University
2009
Background: Trauma is a leading cause of death worldwide and thus major public health concern. Previous studies have shown that limiting the amount fluids given by following strategy permissive hypotension during initial resuscitation period may improve trauma outcomes. This study examines clinical outcomes from first 90 patients enrolled in prospective, randomized controlled trial hypotensive resuscitation, with primary aim assessing effects limited transfusion intravenous (IV) fluid on...
The two primary sites of herbicide action in photosynthetic electron transport are the inhibition photosystem II (PS II) and diversion flow through I I). PS inhibitors bind to D1 protein reaction center, thus blocking transfer plastoquinone. Inhibition prevents conversion absorbed light energy into electrochemical results production triplet chlorophyll singlet oxygen which induce peroxidation membrane lipids. acceptors probably accept electrons from iron-sulfur protein, F a /F b . free...
BACKGROUND For nearly a decade, our center performed thromboelastograms (TEGs) to analyze coagulation profiles, allowing rapid data-driven blood component therapy. After consensus recommendations for massive transfusion protocols (MTPs), we implemented an MTP in October 2009 with 1:1:1 ratio of (red cells [RBC]), plasma (fresh-frozen [FFP]), and platelets. We hypothesized that TEG-directed resuscitation is equivalent resuscitation. METHODS All patients receiving 6 units (U) or more RBC the...
Background Hemorrhagic shock is responsible for one third of trauma related deaths. We hypothesized that intraoperative hypotensive resuscitation would improve survival patients undergoing operative control hemorrhage following penetrating trauma. Methods Between July 1, 2007, and March 28, 2013, aged 14 years to 45 with a systolic blood pressure 90 mm Hg or lower requiring laparotomy thoracotomy were randomized 1:1 based on target minimum mean arterial (MAP) 50 (experimental arm, LMAP) 65...
view Abstract Citations (81) References (53) Co-Reads Similar Papers Volume Content Graphics Metrics Export Citation NASA/ADS Radio Jet Propagation and Wide-Angle Tailed Sources in Merging Galaxy Cluster Environments Loken, Chris ; Roettiger, Kurt Burns, Jack O. Norman, Michael The intracluster medium (ICM) within merging clusters of galaxies is likely to be a violent or turbulent dynamical state which may have significant effect on the evolution cluster radio sources. We present results...
Somatostatin (SST) peptide is a potent inhibitor of insulin secretion and its effect mediated via somatostatin receptor 5 (SSTR5) in the endocrine pancreas. To investigate consequences gene ablation SSTR5 mouse pancreas, we have generated model which was specifically knocked down pancreatic beta cells (βSSTR5 Kd ) using Cre‐lox system. Immunohistochemistry analysis showed that expression absent at three months age. At time ablation, βSSTR5 mice demonstrated glucose intolerance with lack...
Selective degeneration of medium spiny neurons and preservation sized aspiny interneurons in striatum has been implicated excitotoxicity pathophysiology Huntington's disease (HD). However, the molecular mechanism for selective sparing vulnerability projection is still elusive. The pathological characteristic HD an extensive reduction striatal mass, affecting caudate putamen. Somatostatin (SST) positive are selectively spared Quinolinic acid/N-methyl-D-aspartic acid induced excitotoxicity,...
Pancreatic and duodenal homeobox-1 (PDX-1) is a transcription factor that regulates insulin expression islet maintenance in the adult pancreas. Our recent studies demonstrate PDX-1 an oncogene for pancreatic cancer overexpressed cancer. The purpose of this study was to therapeutic target both hormonal symptoms tumor volume mouse models cancer, insulinoma neoplasia. Immunohistochemistry human neoplasia specimens revealed marked overexpression, suggesting as "drugable" within these diseases....
Introduction The function of pancreatic somatostatin in insulin secretion is controversial, and the receptor(s) mediating such event has not been exclusively investigated. Aim Methodology To differentiate specific role SSTR5 mouse pancreas, we generated a gene ablation model. Mice homozygous for deletion (SSTR5−/−) wild type (WT) littermate controls underwent whole pancreas perfusion to determine effect on glucose-stimulated secretion. was done with without octreotide added infusion buffer....
Studies were conducted to determine the uptake and metabolism of pigment synthesis inhibiting herbicide clomazone in tolerant-soybean (Glycine max [L.] Merr. cv Corsoy) susceptible-cotton (Gossypium hirsutum Stoneville 825) photomixotrophic cell suspensions. Soybean cotton on a whole plant level are tolerant susceptible clomazone, respectively. Preliminary studies indicated that I50 values for growth, chlorophyll (Chl), β-carotene, lutein were, respectively, >22, 14, 19, 23 times greater...
We have synthesized two photoreactive derivatives of somatostatin, namely [125I-Tyr11,azidonitrobenzoyl (ANB)-Lys4]somatostatin and [125I-Tyr11,ANB-Lys9]somatostatin, used them to characterize somatostatin receptors biochemically in several cell types. Saturation binding experiments carried out the dark demonstrated that [125I-Tyr11,ANB-Lys4]somatostatin bound with high affinity (KD = 126 +/- 39 pM) a single class sites GH4C1 pituitary membranes. The this analog was similar unsubstituted...
Libraries have greatly expanded their monetary and infrastructure investments in electronic journals. In addition, libraries dramatically e-journal holdings through consortial agreements, publisher licenses, aggregator subscriptions. User studies show a marked increase the use of e-journals growing reliance on online journals for scholarship instruction. The increased availability usage has presented with critical management, bibliographic control, access problems. This paper explores...
Galaxy clusters are unique laboratories to investigate turbulent fluid motions and large scale magnetic fields.Synchrotron radio halos at the center of merging galaxy provide most spectacular direct evidence presence relativistic particles fields associated with intracluster medium.The study polarized emission from is extremely important constrain properties physics acceleration transport particles.However, detecting this signal a very hard task current facilities.We use cosmological...
Based on chlorophyll content, hydroponically cultured soybean seedlings were 254, 66, and 13 times more tolerant to clomazone than velvetleaf, corn, smooth pigweed, respectively. Clomazone, at concentrations that inhibited chlorophyll, did not affect fresh weight accumulations of any species except velvetleaf. However, in accumulation was only half as sensitive the leaf content. Uptake 14 C-clomazone from nutrient solution by 72 h after treatment (HAT) (pigweed > velvetleaf corn)...
Objective To examine the long-term effects of Sur KO, SSTR5 and double Sur/SSTR5 KO on insulin secretion glucose regulation. Summary Background Data The sulfonylurea receptor (Sur) somatostatin type 5 (SSTR5) play an integral role in regulatory pathways endocrine pancreas. knockout (KO) mice were generated authors' laboratories crossbred to generate mice. All genotyped by Southern blotting polymerase chain reaction analysis. Methods One-year-old age-matched wild-type control underwent...
Data sharing is essential and pervasive in scientific research. The requirements for data vary as research projects mature iterate through early designs prototypes with a small number of collaborators, develop into publishable results larger collaborator teams. Along the way, preliminary transient often need to be shared, discussed, visualized quick turn-around time order guide next steps project. throughout this process requires that itself along context, such descriptions, provenance,...
Three indicator species [rye ( Secale cereale L.), radish Raphanus sativus and alfalfa Medicago sativa L.)] nonrooted cuttings of `Stevens' cranberry Vaccinium macrocarpon Ait.) vines were grown in pots to establish the dose response levels for a sand-applied phytotoxin(s) from crude extract Pseudomonas syringae (strain 3366) culture. At 114 ppm [milligrams phytotoxin(s)/kilograms sand], material was noninhibitory, whereas 1140 reduced root shoot growth significantly all four species. In...