A5005815526- Fibromyalgia and Chronic Fatigue Syndrome Research
- Rheumatoid Arthritis Research and Therapies
- Musculoskeletal pain and rehabilitation
- Myofascial pain diagnosis and treatment
- Osteoarthritis Treatment and Mechanisms
- Musculoskeletal synovial abnormalities and treatments
- Orthopedic Surgery and Rehabilitation
- Muscle activation and electromyography studies
- Shoulder Injury and Treatment
- Sports injuries and prevention
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Peripheral Neuropathies and Disorders
- Pain Mechanisms and Treatments
- Lower Extremity Biomechanics and Pathologies
- Bone and Joint Diseases
- Systemic Sclerosis and Related Diseases
- Orthopedic Infections and Treatments
- Tendon Structure and Treatment
- Sports Performance and Training
- Knee injuries and reconstruction techniques
- Nutrition and Health in Aging
- Migration, Health and Trauma
- Spondyloarthritis Studies and Treatments
- Body Composition Measurement Techniques
Frederiksberg Hospital
2014-2024
Copenhagen University Hospital
2013-2023
University of Copenhagen
2009-2020
Parker Hannifin (United States)
2017
Capital Region of Denmark
1990-2016
Parker Hannifin (Germany)
2013-2015
Aalborg University
2009-2014
Parker Institute for Cancer Immunotherapy
2005-2014
Aalborg University Hospital
2012
University of Genoa
2011
Twelve men and twelve women 78–81 years of age were studied with muscle biopsies from the right vastus lateralis biceps brachii measurements isometric isokinetic strength for knee‐extension elbow‐flexion. Bicycle ergometry determination heart rate oxygen uptake at submaximal (50 W) “maximal” work loads was also performed. Body cell mass estimated total body potassium. Muscle fibre composition respect to slow twitch (ST = type I) fast (FT II) fibres did not differ between sexes younger...
Abstract Objective Interleukin‐15 (IL‐15) is a proinflammatory, innate response cytokine that mediates pleiotropic effector function in rheumatoid arthritis (RA) inflammatory synovitis. Our objective was to study the ability of HuMax‐IL15, human IgG1 anti–IL‐15 monoclonal antibody, neutralize exogenous and endogenous IL‐15 activity vitro perform phase I–II dose‐escalation trial with HuMax‐IL15 patients active RA. Methods Mononuclear cells from blood synovial fluid (SF) RA were isolated...
Muscle strength is an excellent indicator of general health when based on reliable measurements. data for a healthy population are rare or non-existent. The aim the present study was to measure set normal values isometric and isokinetic muscle all major joint movements body and, from these data, create basis comparison individual with expected value in population.A randomly selected group, aged 20-80 years, Copenhagen City Heart Study were studied. group subgrouped according age gender....
Abstract Muscle weakness frequently accompanies conditions with musculoskeletal pain. It is not clear if this attenuation of force due to peripheral or central processes. The effect experimental muscle pain on maximal voluntary contraction torque and contractile properties was therefore assessed. Experimental reduced the produced by isometric knee extension, but assessed twitch interpolation were affected. This indicates that inhibition centrally mediated. has clinical implications for...
Abstract Objective To compare the quantitative and qualitative information obtained by Doppler ultrasound (US) measurements of wrist joints small hand with postcontrast magnetic resonance imaging (MRI) to correlate results clinical observations in patients rheumatoid arthritis (RA). Methods Twenty‐nine consecutive RA were studied; 196 (29 167 finger joints) examined both US MRI. Parameters inflammation color fraction resistance index (RI) thickness enhanced synovium (in mm) MRI score...
The generalized hypersensitivity associated with fibromyalgia syndrome (FMS) may in part be driven by peripheral nociceptive sources. aim of the study was to investigate whether local and referred pain from active myofascial trigger points (MTrPs) contributes pain. FMS patients healthy controls (n=22 each, age- gender-matched) were recruited. surface area over upper trapezius muscle on each side divided into 13 sub-areas (points) 1cm diameter for point. Pressure threshold (PPT) pattern...
Central pain mechanisms may be prominent in subsets of patients with rheumatoid arthritis (RA), psoriatic (PsA) and other spondyloarthritis (SpA). The painDETECT questionnaire (PDQ) identifies neuropathic features, which act as a proxy for centrally mediated pain. objectives were to quantify characterize phenotypes (non-neuropathic vs. features) among Danish using the PDQ, assess association on-going inflammation.The PDQ was included onto DANBIO touch screens at 22 departments Rheumatology...
Objective Exercise has beneficial effects on pain in knee osteoarthritis (OA), yet the underlying mechanisms are unclear. The purpose of this study was to investigate exercise pressure–pain sensitivity patients with OA. Methods In a randomized controlled trial, participants were assigned 12 weeks supervised therapy (ET; 36 sessions) or no attention control group (CG). Pressure–pain assessed by cuff pressure algometry calf most symptomatic leg. coprimary outcomes thresholds (PPTs) and...
It is well known that patients suffering from rheumatoid arthritis have a reduced muscular function. The positive effect of physical training on rheumatic has been shown. In this study the exercise therapy performed in heated swimming pool evaluated for eight non-acute stage arthritis. median pre-treatment maximal isometric and isokinetic quadriceps strength was 88 Nm (44-146) 99 (62-149) respectively, which 61% 70% found control group healthy persons. After 2 months increased by 38% 16%...
Study Design. A descriptive study involving maximal isometric strength measurements of the cervical musculature. Objectives. To determine flexors and extensors musculature in 100 healthy volunteers (50 men 50 women). Summary Background Data. The literature contains only a few studies pertaining to levels These include small subject populations, measurement methods have demonstrated weak reliability. Methods. Testing was carried out using strain-gauge technology on neck muscle training...
AbstractS-adenosylmethionine is a relatively new anti-inflammatory drug with arjalgesic and antidepressant effects. Efficacy of 800 mg orally administered s-adenosylmethionine daily versus placebo for six weeks was investigated in 44 patients primary fibromyalgia double-blind settings. Tender point score, isokinetic muscle strength, disease activity, subjective symptoms (visual analog scale), mood parameters side effects were evaluated. Improvements seen clinical activity (P=0.04), pain...
Background: Periodontitis shares several clinical and pathogenic characteristics with chronic arthritis, there is some degree of coexistence. The aims this study were to elucidate whether patients localized aggressive periodontitis (LAgP), generalized (GAgP), juvenile idiopathic arthritis (JIA), rheumatoid (RA) share periodontal hematological distinguishing them from individuals free diseases. Methods: population consisted white adults (≤35 years old) LAgP (N = 18), GAgP 27), JIA 10), RA...
Abstract Objective A previous study demonstrated an association between self‐reported widespread body pain and increased mortality. The aim of this was to analyze whether fibromyalgia (FM) FM‐like symptoms are related Methods From hospital records, we identified 1,361 patients referred during the period 1984–1999 because suspicion FM. cases were reviewed by reviewers who blinded outcome. cohort followed up for a total 5,295 person‐years at risk linked Danish Mortality Register. Using number...
1H NMR spectroscopy-based metabolic phenotyping was used to identify biomarkers in the plasma of patients with rheumatoid arthritis (RA). Forty-seven RA (23 active disease at baseline and 24 remission) 51 healthy subjects were evaluated during a one-year follow-up assessments activity (DAS-28) spectroscopy samples. Discriminant analysis provided evidence that profiles predicted severity. Cholesterol, lactate, acetylated glycoprotein, lipid signatures found be candidate for The results also...