A5060666840- HIV/AIDS Research and Interventions
- Neuroscience and Neuropharmacology Research
- Racial and Ethnic Identity Research
- Receptor Mechanisms and Signaling
- Mental Health Treatment and Access
- HIV, Drug Use, Sexual Risk
- Migration, Health and Trauma
- Health Education and Validation
- Anesthesia and Neurotoxicity Research
- Palliative Care and End-of-Life Issues
- Intraocular Surgery and Lenses
- Cultural Differences and Values
- Mobile Health and mHealth Applications
- Pneumocystis jirovecii pneumonia detection and treatment
- E-Learning and COVID-19
- Liver Disease Diagnosis and Treatment
- Ethics in Clinical Research
- Neural dynamics and brain function
- Primary Care and Health Outcomes
- Telemedicine and Telehealth Implementation
- Glaucoma and retinal disorders
- Innovations in Medical Education
- Global Health Workforce Issues
- HIV-related health complications and treatments
- Mental Health and Patient Involvement
University of Toronto
2024-2025
McGill University
2018-2025
McGill University Health Centre
2020-2024
Canadian Institutes of Health Research
2020-2024
Alberta Children's Hospital
2018-2021
University of Calgary
2016-2021
University of Alberta
2018-2021
Mentor
2020
Biomedical Research Institute
2020
Virginia Tech
2020
Children acquire attention skills rapidly during early childhood as their brains undergo vast neural development. Attention is well studied in the adult brain, yet due to challenges associated with scanning young children, investigations are sparse. Here, we examined relationship between age, and functional connectivity (FC) passive viewing multiple intrinsic networks (ICNs) 60 typically developing girls 4 7 years whose sustained, selective executive were assessed. Visual, auditory,...
Objectives: To compare explicit and implicit stigmatizing attitudes towards mental illness among undergraduate students, medical school psychiatrists, to assess whether are associated with education level, exposure to, personal experience illness. Methods: Participants from McMaster University were recruited through email. completed a web-based survey consisting of demographics; the Opening Minds Scale for Healthcare Providers (OMS-HC) 12-item survey, which measures stigma; an Implicit...
Anesthetics may interact with ionotropic glutamate receptors to produce some of their biologic actions. Cellular studies reveal that the receptors, N-methyl-D-aspartate (NMDARs), can be phosphorylated on NR1 subunits at C-terminal serine residues, which is a major mechanism for regulation NMDAR functions. It currently unknown whether anesthetics have any modulatory effects subunit phosphorylation.The possible effect general anesthetic propofol phosphorylation 897 (pNR1S897) and 896...
The regulation of protein phosphorylation requires coordinated interaction between kinases and phosphatases (PPs). Recent evidence has shown that the Galphaq-protein-coupled metabotropic glutamate receptor (mGluR) 5 up-regulates MAPK/ERK1/2. However, signaling mechanisms linking mGluR5 to ERK are poorly understood. In this study, roles a major serine/threonine PP, PP2A, in event were evaluated cultured neurons. We found PP1/2A inhibitors okadaic acid calyculin A mimicked effect agonists...
The glutamate receptor adaptor protein Homer is concentrated in the postsynaptic density of excitatory synapses and critical for normal operation synaptic transmission. In this study, we investigated responsiveness family proteins to dopamine stimulation with psychostimulant cocaine rat striatal neurons both vivo vitro. We found that a single dose specifically induced rapid transient increase levels Homer1a, but not Homer1b/c Homer2a/b, isoforms striatum. This selective Homer1a induction was...
Abstract Objective Multidisciplinary care with free, rapid, and on‐site bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) dispensation may improve health outcomes among migrants living HIV. However, models for rapid B/F/TAF initiation are not well studied HIV, an understanding of how social determinants (SDH) affect HIV‐related enrolled in such is limited. Methods Within a 96‐week pilot feasibility prospective cohort study at multidisciplinary HIV clinic, participants received free...
Background Intravenous anesthetics cause amnesia, but the underlying molecular mechanisms are poorly understood. Recent studies reveal a significant role of extracellular signal-regulated protein kinases (ERKs) in controlling synaptic plasticity and memory formation. As major synapse-to-nucleus superhighway, ERK transmits N-methyl-D-aspartate (NMDA) receptor signals to inducible transcriptional events essential for NMDA receptor-dependent forms memory. This study investigated widely used...
Gαq-protein-coupled group I metabotropic glutamate receptors (mGluRs) are densely expressed in brain neurons and actively involved various cellular activities. In this study, we investigated the role of mGluRs regulating c-Jun N-terminal kinase (JNK)/stress-activated protein cultured neurons. We found that selective activation mGluR5 induced a rapid transient phosphorylation JNK. series studies to determine mechanisms, conventional mGluR5-associated signaling pathways...
Purpose: To generate Cronbach’s alpha and further mixed methods construct validity evidence for the Blended Learning Usability Evaluation–Questionnaire (BLUE-Q).Methods: Forty interprofessional clinicians completed BLUE-Q after finishing a 3-month long blended learning professional development program in Ontario, Canada. Reliability was assessed with α each of 3 sections all quantitative items together. Construct evaluated through Grand-Guillaume-Perrenoud et al. framework, which consists...
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic worldwide and can progress to serious complications, including metabolic steatohepatitis (MASH), cirrhosis, end-stage disease, hepatocellular carcinoma. Predisposing risk factors for MASH include obesity, type 2 diabetes, dyslipidemia, syndrome. Patients with often experience significant impairments in their health-related quality of life other patient-reported outcomes (PROs), particularly physical...
There is growing interest in how exposure to videogames associated with young children's development. While may displace time from developmentally important activities and have been related lower reading skills, work older children adolescents has suggested that experience attention-demanding/fast-reaction games positively associates attention visuomotor skills. In the current study, we assessed 154 aged 4-7 years (77 male; mean age 5.38) whose parents reported average daily weekday...
Background: Calls for stakeholders across the global HIV landscape to widely and systematically adopt person-centered care patient-oriented research approaches have been made by scholars, clinicians, patients, groups such as Joint United Nations Programme on HIV/AIDS (UNAIDS). Such calls implicitly acknowledge that end goal of care, research, advocacy goes beyond viral suppression or undetectability toward ensuring optimal health-related quality life (HrQoL) people living with (PLWH)....
Abstract Background Scholars recommend providing migrants living with HIV (MLWH) free treatment, rapidly, once linked to care optimize their HIV-related experiences and health outcomes. Quantitative evaluations of patient-reported measures for MLWH in such models are necessary explore the viability these recommendations. Methods Within a 96-week prospective cohort study at multidisciplinary clinic, participants received bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) rapidly...
Background: As people living with HIV (PWH) age, they face new challenges that can have a negative impact on their quality of life (QOL) and mental health. Setting: This study enrolled PWH at the end (EOL) who were actively engaged in cure-related research Southern California, United States. EOL was defined as having prognosis six months or less to live. We examined relationship between QOL, health, participation. Methods: Structured assessments used collect comprehensive data QOL Results:...
Digital health interventions (DHIs) are being increasingly adopted to improve care outcomes and experiences for people living with HIV (PLHIV). Here, we highlight the importance of DHIs in context management recommendations their equitable integration cascade. Gogishvili et al crucial role digital improving experiences. They provide cascade, emphasizing need address divide ensure inclusive access healthcare.
Purpose: The primary aim of this study is to validate the Blended Learning Usability Evaluation – Questionnaire (BLUE-Q) for use in field health professions education through a Bayesian approach. As questionnaire validation remains elusive, secondary article serve as simplified tutorial engaging such practices education.Methods: A total 10 education-based experts blended learning were recruited participate 30-minute interviewer-administered survey. On 5-point Likert scale, rated how well...
Objective To assess explicit and implicit attitudes toward mental illness of undergraduate students explore associated variables. Participants: Year 1–4 from a large Canadian university (n = 382). Methods: Participants completed demographics, the Opening Minds Scale for Healthcare Providers, an Implicit Association Test. Two-tailed independent paired-samples t-tests, ANOVA were performed with significance level at p < .05. Results: About 67.5% self-reported having experienced 31.2% had been...