Isaac H Y Chan

ORCID: 0000-0003-3715-2182
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About
Contact & Profiles
Research Areas
  • Ovarian cancer diagnosis and treatment
  • BRCA gene mutations in cancer
  • Antibiotic Use and Resistance
  • Antibiotic Resistance in Bacteria
  • RNA modifications and cancer
  • Dermatology and Skin Diseases
  • Travel-related health issues
  • Peripheral Artery Disease Management
  • DNA Repair Mechanisms
  • Allergic Rhinitis and Sensitization
  • Infectious Diseases and Tuberculosis
  • Urticaria and Related Conditions
  • Pneumocystis jirovecii pneumonia detection and treatment
  • Tuberculosis Research and Epidemiology
  • Bacterial Identification and Susceptibility Testing

Harvard University
2022-2023

UNSW Sydney
2016-2020

Liverpool Hospital
2017

South Western Sydney Local Health District
2017

St George Hospital
2016

Purpose The known epithelial ovarian cancer (EOC) susceptibility genes account for less than 50% of the heritable risk suggesting that other exist. aim this study was to evaluate contribution rare deleterious germline variants in a set candidate genes. Methods We sequenced coding region 54 6385 invasive EOC cases and 6115 controls broad European ancestry. Genes with an increased frequency putative versus were further examined independent 14 135 28 655 from Ovarian Cancer Association...

10.1136/jmedgenet-2019-106739 article EN cc-by Journal of Medical Genetics 2020-06-16

The role of antibiotic overuse in intensifying selection pressures and contributing to the emergence antimicrobial resistance is well established. Kumbh Mela, a religious festival that occurs 4 Indian cities spiritual significance, world's largest mass gathering, attracting over 80 million pilgrims 2013. Digital syndromic surveillance from 2013 2015 Melas demonstrated consistent pattern overuse, with an prescribing rate up 31% for all patient encounters. As preparations 2025 Mela begin, task...

10.2196/45121 article EN cc-by JMIR Public Health and Surveillance 2023-02-20

Abstract Purpose The known EOC susceptibility genes account for less than 50% of the heritable risk ovarian cancer suggesting other exist. aim this study was to evaluate contribution rare deleterious germline variants in a set candidate genes. Methods We sequenced coding region 54 6385 invasive cases and 6115 controls broad European ancestry. Genes with an increased frequency putative verses were further examined independent 14,146 28,661 from association consortium UK Biobank. For each...

10.1101/19011924 preprint EN cc-by-nc-nd medRxiv (Cold Spring Harbor Laboratory) 2019-11-29

<sec> <title>UNSTRUCTURED</title> The role of antibiotic overuse in intensifying selection pressures and contributing to the emergence antimicrobial resistance is well established. Kumbh Mela, a religious festival that occurs 4 Indian cities spiritual significance, world’s largest mass gathering, attracting over 80 million pilgrims 2013. Digital syndromic surveillance from 2013 2015 Melas demonstrated consistent pattern overuse, with an prescribing rate up 31% for all patient encounters. As...

10.2196/preprints.45121 preprint EN 2022-12-16
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