A5103244467- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Radiopharmaceutical Chemistry and Applications
- Dupuytren's Contracture and Treatments
- Soft tissue tumor case studies
- COVID-19 epidemiological studies
- Chemical Synthesis and Analysis
- Nanoparticle-Based Drug Delivery
- Hematological disorders and diagnostics
- Neurofibromatosis and Schwannoma Cases
- Immunotherapy and Immune Responses
Technische Universität Berlin
2005-2021
Charité - Universitätsmedizin Berlin
2005-2021
Humboldt-Universität zu Berlin
2021
Freie Universität Berlin
2021
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2021
The functional relevance of preexisting cross-immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a subject intense debate. Here, we show that human endemic (HCoV)–reactive and SARS-CoV-2–cross-reactive CD4+ T cells are ubiquitous but decrease with age. We identified universal immunodominant coronavirus-specific spike peptide (S816-830) demonstrate spike- S816-830–reactive were recruited into immune responses SARS-CoV-2 infection their frequency correlated...
While evidence for pre-existing SARS-CoV-2-cross-reactive CD4 + T cells in unexposed individuals is increasing, their functional significance remains unclear. Here, we comprehensively determined SARS-CoV-2-cross-reactivity and human coronavirus-reactivity individuals. were ubiquitous, but presence decreased with age. Within the spike glycoprotein fusion domain, identified a universal immunodominant coronavirus-specific peptide epitope ( iCope ). Pre-existing spike- -reactive memory...
3130 Background: To meet the increased demand arising from dependence on and decreased intracellular pool of glutamine, tumor cells have in general an upregulated uptake mechanism for glutamine. The rational using a glutamine antimetabolite 6-diazo-5-oxo-L-norleucine (DON) combination with PEGylated glutaminase (PEG-PGA) is based premise that effectiveness DON will be enhanced when available strongly depleted by enzyme. Methods: In second step this phase I study patients various advanced...