A5101502136- Hormonal and reproductive studies
- Pharmacological Effects and Assays
- Analytical Chemistry and Chromatography
- Mass Spectrometry Techniques and Applications
- Forensic Toxicology and Drug Analysis
- Muscle metabolism and nutrition
- Doping in Sports
- Pharmacology and Obesity Treatment
- Estrogen and related hormone effects
- Metabolomics and Mass Spectrometry Studies
- GABA and Rice Research
- Cannabis and Cannabinoid Research
- Pesticide Residue Analysis and Safety
- Effects and risks of endocrine disrupting chemicals
- Hormonal Regulation and Hypertension
- Psychedelics and Drug Studies
- Pharmacogenetics and Drug Metabolism
- Advanced Chemical Sensor Technologies
- Biochemical Analysis and Sensing Techniques
- Biodiesel Production and Applications
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Axial and Atropisomeric Chirality Synthesis
- Menopause: Health Impacts and Treatments
- Behavioral Health and Interventions
- Berberine and alkaloids research
Universidade Federal do Rio de Janeiro
2013-2025
Centro de Tecnologia Mineral
2008
Universidade Federal de Alfenas
2007
Low-carbon fuels, emitting less carbon than fossil are proposed to help in the transition a sustainable, decarbonized transport sector.
BackgroundThe use of androgenic anabolic steroids (AAS) may be associated with changes in atherothrombotic markers and endothelial function. The purpose this study was to compare function AAS users non-users.
This paper summarises the results obtained from doping control analyses performed during Summer XXXI Olympic Games (August 3–21, 2016) and XV Paralympic (September 7–18, 2016). The of all samples were at Brazilian Doping Control Laboratory (LBCD), a World Anti‐Doping Agency (WADA)‐accredited laboratory located in Rio de Janeiro, Brazil. A new facility Janeiro Federal University (UFRJ) was built fully operated by over 700 professionals, including international scientists, administrative...
The detection and unambiguous identification of anabolic-androgenic steroid metabolites are essential in clinical, forensic, antidoping analyses. Recently, sulfate phase II have received increased attention metabolism drug testing. In large part, this is because excreted for an extended time, making them a potential long-term chemical marker choice tracking misuse sports. Comprehensive analytical methods, such as liquid chromatography–tandem mass spectrometry (LC–MS/MS), been used to detect...
The Cannabis market is experiencing steady global growth. herbal extracts (CHE) are interesting and sought-after products for many clinical conditions. medical potential of these formulations mainly attributed to neutral cannabinoids, such as cannabidiol (CBD), tetrahydrocannabinol (THC), cannabinol (CBN), their non-standardized content poses a significant fragility in pharmaceutical inputs. High-resolution mass spectrometry portrays powerful alternative accurate monitoring; however, further...
ABSTRACT Trema micranthum (L.) Blume is a species from the Cannabaceae botanical family, present all over tropics. A recent study conducted by our group identified presence of cannabidiol (CBD), Δ 9 ‐tetrahydrocannabinol, cannabidiolic acid, and tetrahydrocannabinolic acid‐A in T. extracts. Their plant's fruit, inflorescence, leaf extracts was detected quantified. has been as potential new source cannabinoids such CBD. The work focuses on Cannabinoid Profiling System (CPS) to wide view...
The use of androgenic-anabolic steroids (AAS) can be associated with psychiatric symptoms such as insomnia, anxiety and increased aggressiveness. Although dose-dependent effects have been observed in some controlled studies, this association is not always seen the ecological AAS. This study utilized WADA's steroid profile suspicious AAS, urinary detection AAS metabolites measurement sexual hormones to confirm recent a cohort 103 bodybuilders (75 males, 28 females). majority participants...
Abstract Dietary supplements (DS) are intended for healthy people to maintain or improve their overall health. Its consumption is widespread in large part of the general population and at all levels athletes. Nevertheless, DS use can also pose health risks individuals and, case athletes, may lead adverse analytical findings (AAFs) due possibility contamination adulteration with doping agents banned by World Anti‐Doping Agency. Although educational initiatives being performed Brazil warn...
Abstract Higenamine is prohibited in sports as a β 2 ‐agonist by the World Anti‐Doping Agency. As key component of great variety plants, including Annonaceae family, one aim this research project was to evaluate whether ingestion Annona fruit could lead higenamine adverse analytical findings. Single‐dose administration studies three species (i.e., muricata , cherimola and squamosa ) were conducted, leading findings below established minimum reporting level (MRL) 10 ng/mL urine. In...
Abstract Zebrafish ( Danio rerio ) water tank (ZWT) approach was investigated as an alternative model for metabolism studies based on six different experiments with four compounds. Sibutramine applied the multivariate optimization of ZWT conditions, also comparison among ZWT, humans and mice, beyond role CYP2B6 in ZWT. After optimization, 18 fish 168 hours is minimum requirement a relevant panel biotransformation products. A species resulted observation same hydroxylated metabolites,...
Measuring carbon isotope ratios (CIRs) of urinary analytes represents a cornerstone doping control analysis and has been particularly optimized for the detection misuse endogenous steroids. Isotope ratio mass spectrometry (IRMS) appropriate quality, however, necessitates adequate purities investigated steroids, which requires extensive pre-analytical sample clean-up steps due to both natural presence target high complexity matrix. In order accelerate preparation increase automation process,...
This is a first look at non-targeted screening method based on Orbitrap gas chromatography-mass spectrometry (GC-MS) technology for large number of banned compounds in sports found urine, including exogenous anabolic steroids, β-agonists, narcotics, stimulants, hormone modulators, and diuretics. A simple sample preparation was processed four steps: an enzymatic hydrolysis, liquid-liquid extraction, evaporation, trimethylsilylation. All were able to meet the World Anti-Doping Agency's...
THE AXIAL CHIRALITY IN BIOACTIVE COMPOUNDS.Atropisomerism is a special kind of stereoisomeric relationship that arises from the freezing certain conformation an organic molecule, associated with high rotational barrier about single covalent bond.Atropisomerism has been originally described in orto-functionalyzed biphenyl derivatives, but lot other functionalities can present this structural phenomenon, characterized by presence chiral properties compounds don't classical stereogenic...
Abstract Trimethylsilylation of anabolic agents and their metabolites is frequently achieved by using the derivatization mixture N ‐methyl‐ ‐(trimethylsilyl)trifluoroacetamide (MSTFA)/NH 4 I/2‐mercaptoethanol. Nevertheless, artifacts were formed when this was employed in monitoring exemestane its main metabolite 17β‐hydroxyexemestane prior to GC‐MS analysis. These identified as ‐methyltrifluoroacetamide (MTFA) trimethylsiloxyethylmercapto products respective trimethylsilyl (TMS) derivatives....
A simple multiresidue and multiclass procedure is described for the simultaneous determination of anabolic agents β2-agonists from 4 classes prohibited substances illegal use in food-producing animals, according to Council Directive 96/23/EC. The method involves analysis hydrolysed urinary compounds using liquid–liquid extraction, with subsequent conversion trimethylsilylether derivatives that are analysed by GC-MS/MS. oven was set an initial temperature 140°C, increased at a rate 10°C/min...