A5103145755- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease and Transplantation
- Liver physiology and pathology
- Plant Reproductive Biology
- Plant biochemistry and biosynthesis
- Hepatitis Viruses Studies and Epidemiology
- Radiopharmaceutical Chemistry and Applications
- interferon and immune responses
- RNA Research and Splicing
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Diseases and Immunity
- Cytokine Signaling Pathways and Interactions
- Reinforcement Learning in Robotics
- Systemic Lupus Erythematosus Research
- Soybean genetics and cultivation
- Mechanical Behavior of Composites
- Folate and B Vitamins Research
- Mast cells and histamine
- Composite Structure Analysis and Optimization
- Genetic and Kidney Cyst Diseases
- Cancer Research and Treatments
- Connexins and lens biology
- Mass Spectrometry Techniques and Applications
Nagasaki University
1996-2024
Kyushu University
2023-2024
Ehime University
2017-2022
Konan University
2020
Stanley Electric (Japan)
2019
Matsuyama University
2017
Nagahama Institute of Bio-Science and Technology
2016-2017
Hebei Rehabilitation Hospital
2016
Tokyo Institute of Technology
1990-2015
University of Tsukuba
1993-2009
Journal Article Expression in Human Hepatocellular Carcinoma of Nucleoside Diphosphate Kinase, a Homologue the nm23 Gene Product Get access Toshihiro Nakayama, Nakayama The First Department Internal Medicine, Nagasaki University School MedicineJapan Search for other works by this author on: Oxford Academic PubMed Google Scholar Akira Ohtsuru, Ohtsuru Cell Physiology, Atomic Disease Institute, Kazuhiko Nakao, Nakao Masayoshi Shima, Shima Keisuke Nakata, Nakata Kazutada Watanabe, Watanabe...
The role of host genetic factors in chronic hepatitis B virus (HBV) infection is not fully understood. We studied the influence tumor necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10) gene promoter polymorphisms on disease progression HBV carriers.The sample population included 213 Japanese carriers 52 healthy volunteers. Of carriers, 66 were considered to be asymptomatic based sustained normalization serum ALT together with seropositivity for antibody e antigen (anti-HBe), 147...
Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase (COX) activity and are considered to exert antitumor actions in a variety of cancer cells, although the effects unlikely entirely due COX inhibition. Because clinical observations suggest that hepatocyte growth factor (HGF) can promote metastasis hepatoma cells while stimulating tumor invasiveness, we investigated effect aspirin NS-398, selective COX-2 inhibitor, on HGF-mediated invasiveness HepG2 human cells. HGF...
Though deep reinforcement learning has led to breakthroughs in many difficult domains, these successes have required an ever-increasing number of samples. As state-of-the-art (RL) systems require exponentially increasing samples, their development is restricted a continually shrinking segment the AI community. Likewise, cannot be applied real-world problems, where environment samples are expensive. Resolution limitations requires new, sample-efficient methods. To facilitate research this...
Abstract We have successfully demonstrated a high output power of 1.19 W from two-dimensional 16 × blue GaN-based vertical-cavity surface-emitting laser (VCSEL) array under continuous wave operation at lasing wavelength 447 nm. A 256-element VCSEL exhibited high-quality far-field beam pattern with circular shape and narrow divergence angle around 7°. very small shift the change in dissipated 0.05 nm −1 revealed low thermal resistance 3.4 K .
Transforming growth factor-β1 (TGF-β1) has been shown to induce apoptosis in normal or transformed hepatocytes. To elucidate the biochemical pathways leading induced by TGF-β1 human hepatoma cells (HuH-7), we examined expression of Bcl-2-related proteins and X-chromosome-linked inhibitor (XIAP), activation caspase cascade following treatment. Bcl-xL began decline at 12 hours after treatment progressively decreased very low levels a time-dependent manner. Bax showed little change throughout...
Hepatitis B virus (HBV) is closely linked to hepatocellular carcinoma (HCC). The objective of the current study was identify factors involved in prognosis patients with HBV-associated HCC using multivariate analysis.The included 74 who were admitted Nagasaki University Hospital, Nagasaki, Japan, between 1983-1998. Of these, 13 underwent surgical tumor resection; 43 received nonsurgical treatment transcatheter arterial embolization, percutaneous ethanol injection, or both; and 18 followed...
OBJECTIVES: The aim of the present study was to clarify risk factors for nonalcoholic fatty liver in young adults. METHODS: One thousand two hundred students, aged 18–21 yr, received matriculation health examinations, including measurements body mass index and percent fat determination serum levels ALT at Nagasaki University 1998. twenty-nine were found have borderline or elevated ALT, 105 129 students (75 men 30 women) subjected further analysis presence using ultrasonography, by which both...
To elucidate the role of PTH in postmenopausal bone loss, we studied 33 patients who received total thyroidectomy due to thyroid carcinoma. Among these patients, 13 were with hypoparathyroid function (HPf), and 20 retained normal parathyroid (NPf) after thyroidectomy. Bone mineral density (BMD), rate BMD incidence spinal deformity as well varying metabolic markers analyzed all patients. The age-matched was clearly higher, significantly lower HPf than NPf. loss NPf during early period (within...
Background. Transcatheter arterial embolization (TAE) is a useful treatment modality for hepatocellular carcinoma (HCC). To study the prognostic factors, survival time of patients with HCC after TAE was analyzed retrospectively using clinical manifestations coexisting liver cirrhosis and features HCC. Methods. Eighty-seven were treated between 1984 1991 observed at Nagasaki University Hospital. All also had cirrhosis. Results. The 87 ranged from 2 months to 8.1 years (mean ± standard...
Hepatitis B virus with a G-to-A point mutation at nucleotide 83 in the precore region (mutant hepatitis 83), which cannot produce HBeAg, is commonly found HBe antibody-positive carriers. We analyzed consecutive changes prevalence of mutant during course chronic infection. Forty-five patients who were followed up for more than 2 yr our hospital studied by polymerase chain reaction combination restriction fragment length polymorphism assay. Mutant was 14 18 (78%) and 8 27 (30%) HBeAg-positive...
Abstract Although a loss of healthy pollen grains induced by metabolic heat responses has been indicated to be major cause heat-induced spikelet sterility under global climate change, date detailed information at level lacking due the technical limitations. In this study, we used picolitre pressure-probe-electrospray-ionization mass spectrometry (picoPPESI-MS) directly determine metabolites in heat-treated single mature two cultivars, heat-tolerant cultivar, N22 and heat-sensitive...
Hepatitis C virus (HCV) infection is a heterogeneous disease, the natural history of which remains controversial. There solid evidence that chronic HCV responsible for occurrence hepatocellular carcinoma (HCC). The aim current cohort study was to determine rate development HCC from time primary and assess risk factors in posttransfusion hepatitis patients.Four hundred sixty-nine patients with clinically compensated HCV, who had undergone single blood transfusion comprised cohort. Patients...
Abstract Watercore is a physiological disorder in apple ( Malus × domestica Borkh.) fruits that appears as water-soaked tissues adjacent to the vascular core, although there little information on what exactly occurs at cell level watercored apples, particularly from viewpoint of water relations. By combining picolitre pressure-probe electrospray-ionization mass spectrometry (picoPPESI-MS) with freezing point osmometry and vapor pressure osmometry, changes status metabolisms were spatially...
Small cell lung cancer (SCLC) is one of the deadliest human cancers, with a 5-year survival rate ∼7%. Here, we performed targeted proteomics analysis SCLC samples and thereby identified hypoxanthine phosphoribosyltransferase 1 (HPRT1) in salvage purine synthesis pathway as factor that contributes to malignancy by promoting glutamine-starved environment. Inhibition HPRT1 6-mercaptopurine (6-MP) combination methotrexate (MTX), which blocks de novo pathway, attenuated growth mouse xenograft...
Epidermal growth factor (EGF) and 12-O-tetradecanoylphorbol-13-acetate (TPA) synergistically suppress activities of the promoter enhancer human alpha-fetoprotein (AFP) gene in HuH-7 hepatoma cells as analyzed by transient transfection assays using chloramphenicol acetyltransferase a reporter. In contrast to AFP gene, albumin were not affected EGF TPA. Unexpectedly, however, Northern blot analysis revealed that mRNA level well reduced treatment with We propose cells, stimulates promoter;...
Recent studies have reported that antiangiogenic gene delivery into cancer cells inhibits growth of certain tumors in vivo. Hepatocellular carcinoma (HCC) is a hypervascular cancer, and therapy might be suitable for HCC. In the present study, we investigated effects angiostatin transduction HCC both vitro Angiostatin was cloned pSecTag2B mammalian expression vector to construct pSecTag2B-ANG. or pSecTag2B-ANG were transfected an cell line, PLC/PRF/5, then stable transfectants obtained by...
Abstract Most patients with hepatocellular carcinoma (HCC) in Japan have hepatitis B virus (HBV)‐or C (HCV)‐associated cirrhosis. In the present study, risk of HCC cirrhosis was analysed by levels serum alanine aminotransferase (ALT). One hundred and one (78%) 129 registered from April 1979 were followed at monthly intervals measurement ALT. Of 101 patients, 38 tested positive for surface antigen (HBsAg) but negative antibody to HCV (anti‐HCV; HBV group), 47 HBsAg anti‐HCV (HCV group) nine...