A5081259860- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Cancer Research and Treatments
- Nanoplatforms for cancer theranostics
- Cancer-related Molecular Pathways
- Neurogenesis and neuroplasticity mechanisms
- Prion Diseases and Protein Misfolding
- Digestive system and related health
- Nerve injury and regeneration
- T-cell and B-cell Immunology
- SARS-CoV-2 and COVID-19 Research
- Pluripotent Stem Cells Research
- Nutrition, Genetics, and Disease
- Sulfur Compounds in Biology
- Skin Protection and Aging
- CRISPR and Genetic Engineering
- Vaccine Coverage and Hesitancy
- Biomedical Ethics and Regulation
- BRCA gene mutations in cancer
- Estrogen and related hormone effects
- vaccines and immunoinformatics approaches
- Metabolism, Diabetes, and Cancer
- Chemokine receptors and signaling
- Spinal Cord Injury Research
Neostem (United States)
2015
University of California, Irvine
2006-2013
University of Illinois Chicago
2004-2009
Women with mutations in the breast cancer susceptibility gene BRCA1 are predisposed to and ovarian cancers. Why protein suppresses tumor development specifically hormone-sensitive tissues remains unclear. We demonstrate that mammary glands of nulliparous Brca1/p53-deficient mice accumulate lateral branches undergo extensive alveologenesis, a phenotype occurs only during pregnancy wild-type mice. Progesterone receptors, but not estrogen overexpressed mutant epithelial cells because defect...
Background Motor neuron loss is characteristic of cervical spinal cord injury (SCI) and contributes to functional deficit. Methodology/Principal Findings In order investigate the amenability injured adult motor differentiation, we transplanted animals with a high purity population human progenitors (hMNP) derived from embryonic stem cells (hESCs). vitro, hMNPs displayed neuron-specific markers, typical electrophysiological profile, functionally innervated or rodent muscle, secreted...
The availability of human neuronal progenitors (hNPs) in high purity would greatly facilitate drug discovery and developmental studies, as well cell replacement strategies for neurodegenerative diseases conditions, such spinal cord injury, stroke, Parkinson's disease, Alzheimer's Huntington's disease. Here we describe the first time a method producing hNPs large quantity from embryonic stem cells (hESCs) feeder-free without use exogenous noggin, sonic hedgehog or analogs, rendering process...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a world-wide pandemic. Internationally, because of availability, accessibility, and distribution issues, there is need for additional vaccines. This study aimed to: establish the feasibility personal dendritic cell vaccines to SARS-CoV-2 spike protein, safety single subcutaneous vaccine injection, determine antigen-specific immune response following vaccination. In Phase 1, 31 subjects were assigned one nine formulations...
The epithelial linings of the small and large intestine are rapidly turned over provide an ideal system for exploring links between differentiation regulation cell cycle exit. We utilized wild type, p21-/-, p27-/- p21/p27-/- mice to address contributions Cdk inhibitors p21 p27 proliferation in mouse gastrointestinal tract. did not detect any significant differences proliferation, all differentiated lineages were represented four genotypes. These data indicate that do play essential roles...
This report describes efforts to understand the immune mechanism of action that led a complete response in patient with progressive, refractory, metastatic melanoma after treatment therapeutic vaccine consisting autologous dendritic cells (DC) loaded tumor antigens (ATA) derived from were self-renewing cell culture. Her histocompatibility type proved be HLA B27 extensive mutations HLA-A locus. Exomic analysis proliferating revealed more than 2800 non-synonymous compared her leukocytes....
Because of its role as an immune checkpoint, levels soluble programmed cell death protein-1 (sPD-1) could be useful a prognostic biomarker or predictive in cancer patients treated with vaccines. Very low sPD-1 may indicate lack existing anti-cancer response; very high active response that is suppressed. In between these extremes, decrease PD-1 following injections vaccine enhanced has not been Blood samples obtained during randomized trial metastatic melanoma were tested from 22 tumor (TCV)...
Abstract Aims Amyotrophic lateral sclerosis ( ALS ) results in the selective loss of motor neurons within several years disease onset; however, molecular mechanisms behind pathogenesis remain largely unknown. Among genes responsible for familial , mutations TAR DNA ‐binding protein 43 TDP ‐43) have been identified. The present study evaluated cytotoxicity ‐43 fragments and ‐associated mutants against human embryonic stem cell‐derived neurons. Methods Magnetofection was used to investigate...
Meeting abstracts Caladrius Biosciences has recently identified biomarkers that may predict clinical efficacy in immunotherapy treatments for melanoma. While numerous trials demonstrated success long-term survival using agents various types of malignancies, very few
The purpose of this study was to analyze PD-1 serum levels, in patients with metastatic melanoma who were enrolled a randomized phase 2 trial, determine: [1] if baseline levels prognostic for overall survival (OS), [2] predictive benefit the specific treatment arms, [3] changed between week-0 and week-4 by treatment, [4] changes treatment. Patients clinical trial comparing autologous dendritic cell vaccines (DCV) presenting tumor antigens (ATA) derived from irradiated cancer cells short-term...
132 Background: Dendritic cells (DC) loaded with autologous tumor antigens in vitro, can induce a Th17 phenotype preceding Th1 type response. We examined this patients metastatic melanoma who had been treated randomized trial either DC (ATA) from self-renewing (DCV) or irradiated (TCV). Methods: Blood samples were obtained at baseline, one week before three weekly vaccinations (week-0), and week-4, (one after the third vaccination). They analyzed for growth factors, markers biomarkers using...
Abstract The purpose of this study was to analyze PD-1 serum levels, in patients with metastatic melanoma who were enrolled a randomized phase 2 trial, determine: [1] if baseline levels prognostic for overall survival (OS), [2] predictive benefit the specific treatment arms, [3] changed between week-0 and week-4 by treatment, [4] changes treatment. Patients clinical trial comparing autologous dendritic cell vaccines (DCV) presenting tumor antigens (ATA) derived from irradiated cancer cells...
Abstract Standard aggressive therapy for primary newly diagnosed glioblastoma (GBM), which includes surgical resection followed by concurrent radiation and temozolomide chemotherapy (RT/TMZ) then maintenance TMZ, is associated with poor survival rates. Adding treatment AV-GBM-1, a personal vaccine consisting of autologous dendritic cells (DC) pulsed tumor antigens (ATA) may improve survival. AV-GBM-1 produced incubating ATA DC. are from lysate irradiated GBM that were self-renewing in...
<h3>Background</h3> Despite standard aggressive therapy, including maximum safe surgical resection, concurrent radiation therapy and temozolomide chemotherapy (RT/TMZ) followed by maintenance TMZ, survival is still extremely poor for patients with newly diagnosed primary glioblastoma (GBM). Adding treatment AV-GBM-1, a personal vaccine consisting of autologous dendritic cells (DC) pulsed tumor antigens (ATA) may improve survival. One objective multi-center phase II clinical trial was to...