A5000237053- Natural product bioactivities and synthesis
- Phytochemical compounds biological activities
- Phytochemistry and Biological Activities
- Traditional and Medicinal Uses of Annonaceae
- Bioactive natural compounds
- Ethnobotanical and Medicinal Plants Studies
- Natural Compound Pharmacology Studies
- Morinda citrifolia extract uses
- Essential Oils and Antimicrobial Activity
- Biological Activity of Diterpenoids and Biflavonoids
- Plant chemical constituents analysis
- Synthesis of Organic Compounds
- Phytochemicals and Antioxidant Activities
- Phytochemistry and biological activities of Ficus species
- Cancer therapeutics and mechanisms
- Synthesis of Indole Derivatives
- Bioactive Compounds and Antitumor Agents
- Computational Drug Discovery Methods
- Microbial Natural Products and Biosynthesis
- Plant biochemistry and biosynthesis
- Pharmacological Effects of Natural Compounds
- Psidium guajava Extracts and Applications
- Quinazolinone synthesis and applications
- Phytochemistry and Bioactivity Studies
- African studies and sociopolitical issues
Université de Yaoundé I
2015-2024
Bielefeld University
2022
University of Massachusetts Amherst
2020
Abstract Background Cancer remains a global health concern and constitutes an important barrier to increasing life expectancy. Malignant cells rapidly develop drug resistance leading many clinical therapeutic failures. The importance of medicinal plants as alternative classical discovery fight cancer is well known. Brucea antidysenterica African plant traditionally used treat cancer, dysentery, malaria, diarrhea, stomach aches, helminthic infections, fever, asthma. present work was designed...
Artocarpus communis is used traditionally in Cameroon to treat several ailments, including infectious and associated diseases. This work was therefore designed investigate the antimicrobial activities of methanol extract (ACB) compounds isolated from bark this plant, namely peruvianursenyl acetate C (1), α-amyrenol or viminalol (2), artonin E (4) 2-[(3,5-dihydroxy)-(Z)-4-(3-methylbut-1-enyl)phenyl]benzofuran-6-ol (5).The liquid microdilution assay determination minimal inhibitory...
Background Natural products play a key role in drug discovery programs, both serving as drugs and templates for the synthesis of drugs, even though quantities availabilities samples screening are often limitted. Experimental approach A current collection physical > 500 compound derived from African medicinal plants aimed at has been made by donations several researchers across continent to be directly available programs. virtual library 3D structures compounds generated Lipinski's "Rule...
The lack of a safe and effective adult worm drug the emergence resistant animal parasite strains to only recommended drug, microfilaricide, ivermectin put many at risk devastating effects onchocerciasis. present study was undertaken investigate acclaimed anti-Onchocerca activity roots/rhizomes Cyperus articulatus in traditional treatment onchocerciasis North Western Cameroon assess plant as new source potential filaricidal lead compounds. Crude extracts were prepared from dried parts using...
Tuberculosis (TB) is still a global health problem mainly due to development of resistance and co-infection with the Human immune Virus (HIV). Treatment multi extensively drug resistant TB requires use second line drugs which are less efficacious, expensive very toxic. This has necessitated need search for new treatment regimens especially from medicinal plants. Zanthoxylum leprieurii, plant species Rutaceae used locally in tuberculosis Uganda. The aim study was isolate, identify...
Despite the remarkable progress in cancer therapy recent years, this disease still remains a serious public health concern. The use of natural products has been and continues to be one most effective ways fight malignancies. cytotoxicity 14 compounds from African medicinal plants was evaluated four human carcinoma cell lines normal fibroblasts. tested samples included: β-spinasterol (1), friedelanone (2), 16β-hydroxylupeol (3), β-amyrin acetate (4), lupeol (5), sequoyitol (6), rhamnitrin...
The present study aimed to assess the in vitro antibacterial and antibiotic modifying activities of methanol extracts prepared from leaf (APL) bark (APB) Acacia polyacantha, fractions (APLa-d) compounds isolated APL against a panel multidrug resistant (MDR) Gram-negative bacteria. Leaf extract was subjected column chromatography for isolation; assays were performed on samples alone with an efflux pump inhibitor (EPI), respectively, several antibiotics tested phytochemical investigation led...
An extensive phytochemical investigation of the EtOH/H2O (7:3) extracts Sida rhombifolia L. and acuta Burm. f., yielded a previously undescribed ceramide named rhombifoliamide (1) xylitol dimer (2), naturally isolated here for first time, as well thirteen known compounds viz, oleanolic acid (3), β-amyrin glucoside (4), ursolic (5), β-sitosterol (6), tiliroside (7), 1,6-dihydroxyxanthone (8), mixture stigmasterol (9) (10), cryptolepine (11), 20-Hydroxyecdysone (12), (E)-suberenol (13),...
Abstract A new polyprenylated benzophenone, named epunctanone ( 1 ), was isolated from the stem bark of Garcinia epunctata Stapf , together with eight known compounds, 7‐epiisogarcinol 2 2,6‐dimethoxy‐ p ‐benzoquinone 3 friedelin 4 lupeol 5 16 β ‐hydroxylupeol 6 betulin 7 stigmasterol 8 and rheediaxanthone 9 ). The structure ) established by detailed analysis its spectroscopic data, especially 1D‐ 2D‐NMR, HR‐MS data. All these compounds were evaluated for their antimicrobial anti‐protozoan...
Three new lignan glucosides, namely, justisecundosides A (1), B (2a), and C (2b), were isolated from the whole plant of Justicia secunda together with seven known compounds (3-9). Their structures established based on a comprehensive analysis HR-ESI-MS, IR, UV, CD, in conjunction their 1D 2D-NMR data. putative biogenetic pathway 1-2a,b coniferyl alcohol was proposed. In addition, antimicrobialactivities extract, fractions, some assessed against multiresistant bacterial fungal strains....
A new 5-dehydroxyflavan, namely Albiziaflavan B or (+)-(2R, 3S, 4R)-3′,4′, 7-trihydroxy-4-methoxy-2,3-trans-flavan-3,4-trans-diol (1) was isolated from the root bark of Albizia glaberrima, together with six known compounds including three flavans: (+)-mollisacacidin (2), (+)-fustin (3) and butin (4); two steroids: chondrillasterol (5) chondrillasterone (6), a triterpenoid: lupeol (7). The structure 1 established by detailed analysis its spectroscopic data, especially 1D 2D NMR spectra,...
A phytochemical study of Ficus thonningii has led to the isolation two previously unreported compounds, thonningiiflavanonol and B together with 16 known compounds: shuterin, naringenin, syringic acid, p-hydroxybenzoic genistein, 5,7,3',4',5'-pentahydroxyflavanone, luteolin, methylparaben, aromadendrin, garbanzol, dihydroquercetin, 5,7,3'-trihydroxyflavanone, β-sitosterol, sitosterolglucoside, lupeol acetate, taraxerol. Their structures were elucidated on basis spectroscopic data. The new...