A5104174603- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Mesenchymal stem cell research
- Neurogenesis and neuroplasticity mechanisms
- Cell death mechanisms and regulation
- Genetics and Neurodevelopmental Disorders
- Neuroscience and Neuropharmacology Research
- Neuroscience, Education and Cognitive Function
- Environmental Science and Water Management
- DNA Repair Mechanisms
- Axon Guidance and Neuronal Signaling
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Nerve injury and regeneration
- Genetic factors in colorectal cancer
- Signaling Pathways in Disease
- Cancer Genomics and Diagnostics
Rutgers, The State University of New Jersey
2020-2023
Johnson University
2020-2023
University of Zagreb
2017-2018
Neurodevelopment requires precise regulation of gene expression, including post-transcriptional regulatory events such as alternative splicing and mRNA translation. However, translational specific isoforms during neurodevelopment the mechanisms behind it remain unknown. Using RNA-seq analysis mouse neocortical polysomes, here we report translationally repressed derepressed neurogenesis whose orthologs include risk genes for neurodevelopmental disorders. We demonstrate that translation...
Abstract Abnormalities in neocortical and synaptic development are linked to neurodevelopmental disorders. However, the molecular cellular mechanisms governing initial synapse formation prenatal neocortex remain poorly understood. Using polysome profiling coupled with snRNAseq on human cortical samples at various fetal phases, we identify mRNAs, including those encoding proteins, finely controlled translation distinct cell populations of developing frontal neocortices. Examination murine...
Early regional patterning and laminar position of cortical projection neurons is determined by activation deactivation transcriptional factors (TFs) RNA binding proteins (RBPs) that regulate spatiotemporal framework neurogenetic processes (proliferation, migration, aggregation, postmigratory differentiation, molecular identity acquisition, axonal growth, dendritic development, synaptogenesis) within transient cellular compartments. Deep-layer (DPN), subplate (SPN), Cajal–Retzius (CRN) are...
AimTo analyze how neural stem cells (NSC) transplantation in the stroke-affected mouse brain influences expression of genes involved apoptosis-inducing factor (AIF)-mediated cell death – apoptosis inducing mitochondria associated 1 (Aifm1), ring finger protein 146 (Rnf146, Iduna), and cyclophilin A (CypA); necroptosis –receptor interaction kinase (Ripk1), Ripk3, mixed-lineage domain-like (Mlkl); Caspase 3 (Casp3) Casp8.MethodsFour groups animals were used to obtain mRNA for quantitative...
Abstract Homozygous mutations in the gene encoding scavenger mRNA-decapping enzyme, DcpS, have been shown to underlie developmental delay and intellectual disability. Intellectual disability is associated with both abnormal neocortical development mRNA metabolism. However, role of DcpS its decapping activity neuronal unknown. Here, we show that human neurons derived from patients a mutation compromised differentiation neurite outgrowth. Moreover, developing mouse neocortex, required for...
Abstract Homozygous mutations in the gene encoding scavenger mRNA-decapping enzyme, DcpS, have been shown to underlie developmental delay and intellectual disability. Intellectual disability is associated with both abnormal neocortical development mRNA metabolism. However, role of DcpS its decapping activity neuronal unknown. Here, we show that human neurons derived from patients a mutation compromised differentiation neurite outgrowth. Moreover, developing mouse neocortex, required for...