A5037890969- Cancer therapeutics and mechanisms
- Synthesis and biological activity
- Cancer Mechanisms and Therapy
- Curcumin's Biomedical Applications
- Gut microbiota and health
- Natural product bioactivities and synthesis
- melanin and skin pigmentation
- Genomics, phytochemicals, and oxidative stress
- Skin Protection and Aging
- Olfactory and Sensory Function Studies
- Bioactive Compounds and Antitumor Agents
- Synthesis and Biological Evaluation
- Synthesis and Reactions of Organic Compounds
- Ginger and Zingiberaceae research
- Phytochemistry and biological activities of Ficus species
- Natural Antidiabetic Agents Studies
- Phytochemistry and Biological Activities
- Tannin, Tannase and Anticancer Activities
- Bladder and Urothelial Cancer Treatments
- Urinary Tract Infections Management
- Synthesis and bioactivity of alkaloids
Menoufia University
2019-2025
October University of Modern Sciences and Arts
2012
Cervical cancer is the fourth most common affecting women worldwide. Paclitaxel/Carboplatin one of commonly prescribed regimens in cervical treatment. Although chemotherapeutic drugs are very effective, severe side effects and development drug resistance limits use these drugs. The natural products with anticancer activity may help to partially overcome issues.In present study, we investigated ability Gallic acid, potentiate anti-cancer Paclitaxel, Carboplatin combination human HeLa cells by...
Abstract Aging has become a concern for many people, especially women. Given that high-quality anti-aging products are of high cost; it imperative to search other economical sources. Essential oils frequently used in cosmetics due wide range biological activities as well their pleasant odor. The current study aimed investigate the biochemical effect cosmetic potential selected Apiaceous essential oils, traditionally skincare, by evaluating anti-wrinkle activity. It is worth noting that,...
Asthma is a chronic disease affecting people of all ages. medications are associated with adverse effects restricting their long-term usage, demanding newer alternative therapies. This study aimed to investigate the anti-asthmatic properties Ruta graveolens extract and its prepared nano-cubosomal dispersion (Ruta-ND). Firstly, R. methanolic exhibited higher anti-inflammatory activity on Lipopolysaccharide (LPS)-activated BEAS-2B cells. To ensure best bioavailability hence cellular uptake,...
Bladder cancer is a common malignancy in Egypt. A history of urinary tract infection can be considered as risk factor for bladder cancer. Escherichia coli (E. coli) responsible 70% infection. This study aimed to evaluate the role chronic E. during carcinogenesis. In order achieve this aim, we investigated histopathological changes tissue and measured level nuclear kappa p65 (NF-κBp65), Bcl-2 interleukin 6 (IL-6) four groups each consisting 25 male albino rats except control group 20 rats....
ABSTRACT The anticancer potential of certain newly synthesized pyrazole and pyrazolopyridine derivatives has been estimated. NCI 60 cancer cells cytotoxic screening pointed out compounds 3e 3f as the highest agents with % mean growth inhibition 67.69% 87.34%, respectively. five dose outcomes outlined most potent agent promising MG‐MID GI 50 = 3.3 µM when compared to erlotinib (MG‐MID 7.68 µM). In in vitro assays, 3d, 3e, 3f, 4a demonstrated dual inhibitory on EGFR WT VEGFR‐2 IC range...
Aim: A fragment-based design and synthesis of three novel series aminopyridone-linked benzimidazoles as potential anticancer candidates with significant CDK9 inhibition was implemented. Materials & methods: All synthesized compounds were submitted to National Cancer Institute, 60 cell lines seven-dose cytotoxicity toward cancer cells. Results: Compounds 2, 4a, 4c, 4d, 6a 8a exhibited selectivity IC 50 range 7.61–57.75 μM. Regarding the mechanism either in vitro or silico, displayed...
Throughout human history, plant products have been used for many purposes including as medicines. Herbal and spices can be preventive agents against cancer due to their antimicrobial, antioxidant antitumorigenic properties. This study was designed evaluate the potential protective effect of curcum in rats administered nitrosamine precursors; dibutylamine (DBA) sodium nitrate (NaNO3); infected with Escherichia coli (E. coli) also monitor changes nuclear factor Kappa B p65 (NF-κB p56) pathway...
Umbelliferae family represents the broadest plant families. It is mainly distributed in Mediterranean countries. Coriander, cumin, fennel, and anise are Apiaceous species that traditionally used most frequently. The Apiaceae thought to have potential bioactive metabolites as terpenoids, polyacetylenes, polyphenols compounds, essential oils. family's ability exhibit hepatoprotective, antifungal, antimicrobial, antioxidant, antiaging has been convincingly demonstrated a myriad of...