A5087689035- Adenosine and Purinergic Signaling
- Titanium Alloys Microstructure and Properties
- dental development and anomalies
- Oral and Maxillofacial Pathology
- Oral microbiology and periodontitis research
- Powder Metallurgy Techniques and Materials
- Pain Mechanisms and Treatments
- Advanced materials and composites
- Advanced Nanomaterials in Catalysis
- Extracellular vesicles in disease
- Heme Oxygenase-1 and Carbon Monoxide
- Dental Trauma and Treatments
- Bone Tissue Engineering Materials
- Injury Epidemiology and Prevention
- Nanoplatforms for cancer theranostics
- Additive Manufacturing Materials and Processes
- Vagus Nerve Stimulation Research
- Inflammasome and immune disorders
- Neuroscience of respiration and sleep
- Neuroinflammation and Neurodegeneration Mechanisms
- Scientific and Engineering Research Topics
- Bone and Dental Protein Studies
- Periodontal Regeneration and Treatments
Air Force Medical University
2010-2025
National Clinical Research
2025
The University of Texas Health Science Center at San Antonio
2010
<title>Abstract</title> Background Dentigerous cysts are a type of inflammatory odontogenic cyst that arises from tissues surrounding an unerupted or impacted tooth. If left untreated, they can grow into substantial size, resulting in cortical expansion and facial asymmetry. It cause the roots affected teeth to be absorbed, affecting stability tooth loosening displacement. In severe cases, may fall out. addition, if becomes infected, there will obvious pain swelling local area, even fistulas...
Emerging research has revealed that the activation of NLR family pyrin domain containing 3 (NLRP3) inflammasomes contribute to development inflammatory and neuropathic pains. In addition, microglia are involved in central nervous system (CNS) pain conduction. However, relationship between NLRP3 inflammasome dental conduction is yet be established. Therefore, this study aimed investigate roles P2X7 NLRP3/Caspase-1 (CASP1) caused by pulpitis using a rat experimental model. We discovered...
Dental pulpitis often induces severe pain, and the molecular immune response is remarkable in both peripheral central nervous system. Accumulating evidence indicates that activated microglia medullary dorsal horn (MDH) contribute to dental induced pain. The P2X7 receptor plays an important role driving pain inflammatory processes, its downstream target hypoxia-induced factor-1α (HIF-1α) has a crucial maintaining inflammation. However, relationship between HIF-1α remains unclear. This study...
Bone morphogenetic protein 2 (Bmp2) is essential for odontogensis and dentin mineralization. Generation of floxed Bmp2 dental mesenchymal cell lines a valuable application studying the effects on differentiation its signaling pathways during dentinogenesis. Limitation primary culture cells has led to development that serve as good surrogate models study into odontoblasts In this study, we established characterized immortalized mouse papilla lines, which were isolated from 1st mandibular...
Abstract A 3.5‐year‐old girl presented to our clinic experiencing pain in her maxillary central incisors following traumatic injury during a fall. Radiographic examination revealed both primary with mid‐root and apical third horizontal root fractures, respectively. Splinting orthodontic brackets stainless steel wire was performed. At 2 weeks, resorption of the fragments injured teeth observed, after 3 months, almost complete noted on radiographs. Tooth mobility at this point back physiologic...
<title>Abstract</title> Background Pulpitis is a prevalent oral disease characterized by severe pain. The activation of microglia in the medullary dorsal horn (MDH) reportedly essential for central sensitization mechanism associated with pulpitis. And P2X7 receptor (P2X7R) on can trigger secretion exosome enriched IL-1β, which involved inflammation. Thus, we hypothesized that enhanced regulated microglial P2X7R MDH contributes to pulpitis-induced Methods male SD rats were chosen as...