A5042572933- Cancer, Stress, Anesthesia, and Immune Response
- Neuropeptides and Animal Physiology
- Immune Cell Function and Interaction
- Stress Responses and Cortisol
- Inflammatory mediators and NSAID effects
- Advanced Radiotherapy Techniques
- Chemokine receptors and signaling
- Pain Mechanisms and Treatments
- Neuroendocrine regulation and behavior
- Cancer Research and Treatments
- Anesthesia and Neurotoxicity Research
- Tryptophan and brain disorders
- Immune Response and Inflammation
- Immune cells in cancer
- Anesthesia and Pain Management
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer, Hypoxia, and Metabolism
- Immunotherapy and Immune Responses
- Nanoplatforms for cancer theranostics
- Sarcoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Adrenal Hormones and Disorders
- Enhanced Recovery After Surgery
- T-cell and B-cell Immunology
Tel Aviv University
2015-2024
Academic College of Tel Aviv-Yafo
2015-2024
Hologic (Germany)
2024
American Friends of Tel Aviv University
2013
Sheba Medical Center
2005-2012
Institute of Neuroimmunology of the Slovak Academy of Sciences
2010
Outcomes Research Consortium
2008-2009
Rabin Medical Center
2001-2006
Johns Hopkins University
2001-2003
Marymount University
2000
In Brief Postoperative immunosuppression is partly ascribed to anesthesia and has been suggested compromise patients' resistance infection tumor metastasis. We compared the effects of various anesthetics on natural killer (NK) cell activity experimental metastasis, studied mediating mechanisms prophylactic measures. Fischer 344 rats served as controls or were anesthetized for 1 h with ketamine, thiopental, halothane, propofol. Anesthetized either maintained in normothermia left spontaneously...
Stress and surgery have been suggested to compromise host resistance infectious malignant diseases in experimental clinical settings. Because stress affects numerous physiological systems, the role of immune system mediating such effects is unclear. In current study, we assessed degree which stress-induced alterations natural killer (NK) cell activity underlie increased susceptibility tumor development F344 rats. Two paradigms were used: forced swim abdominal surgery. Host was studied using...
Surgical procedures, including primary tumor resection, have been suggested to suppress immune competence and promote postoperative infections cancer metastasis. Catecholamines prostaglandins were recently implicated in these processes, directly promoting angiogenesis invasion.To examine the integration of 2 complementary approaches reduce immunosuppression metastatic progression: (1) perioperative immunostimulation with CpG-C (2) pharmacological blockade tumor-promoting immunosuppressing...
Abstract Purpose: Translational studies suggest that excess perioperative release of catecholamines and prostaglandins may facilitate metastasis reduce disease-free survival. This trial tested the combined blockade these pathways in breast cancer patients. Experimental Design: In a randomized placebo-controlled biomarker trial, 38 early-stage patients received 11 days treatment with β-adrenergic antagonist (propranolol) COX-2 inhibitor (etodolac), beginning 5 before surgery. Excised tumors...
We have previously shown in rats that the provision of analgesic doses morphine significantly reduces tumor-promoting effects undergoing and recovering from surgery. Because had no effect non-operated animals, because a single preoperative dose given hours before tumor inoculation was effective, we suggested it is pain-relieving drug underlies its beneficial impact. To support strengthen this suggestion, two different regimens analgesia were employed, systemic administration more selective...
Background The perioperative period is characterized by a state of immunosuppression, which was shown in animal studies to underlie the promotion tumor metastasis surgery. As this immunosuppression partly ascribed neuroendocrine stress response, authors hypothesized that spinal blockade, known attenuate may reduce tumor-promoting effect Methods Fischer-344 rats were subjected laparotomy during general halothane anesthesia alone or combined with either systemic morphine (10 mg/kg) block using...
Clinical practice does not consider perioperative paracrine and neuroendocrine stress responses as risk factors for cancer recurrence, although recent animal studies provided supportive evidence. Suggested mechanisms include the effects of stress-hormones on tumor cells host physiology. In this study, in mice undergoing primary excision, we tested survival-enhancing potential blockade catecholamines prostaglandins, studied mediating mechanisms. C57BL/6J were inoculated intrafootpad with...
Abstract The sympathetic nervous system has been implicated in mediating stress-induced alterations NK cell activity, particularly through stimulation of β-adrenergic receptors. However, because catecholamines induce time-dependent the distribution cells, impact on individual cytotoxicity is not clear, nor are its implications regarding host resistance to metastatic spread. To address these issues, we used agonist, metaproterenol (MP), F344 rats. number blood cells doubled within 10 min MP...
Although acute stress has been reported to suppress natural killer cell activity (NKA) and host resistance metastasis, it is unclear whether the sympathetic nervous system (SNS) a role in these effects. The current study Fischer 344 rats assessed involvement of adrenal catecholamines β<sub>1</sub>- β<sub>2</sub>-adrenoceptors mediating deleterious effects swim stress. In addition assessing number NK cells following stress, we used tumor model based on MADB106 mammary...
<i>Objectives:</i> Opiates, which serve an integral role in anesthesia, suppress immune function, particularly natural killer cell cytotoxicity (NKCC). NK cells play important tumor and metastasis surveillance. We reported that large-dose fentanyl anesthesia induced prolonged suppression of NKCC patients undergoing abdominal surgery. The modulatory effects opiates may depend on the interaction between dose time administration. present study examined different doses fentanyl,...
In cancer patients, allogeneic blood transfusion is associated with poorer prognosis, but the independent effect of controversial. Moreover, mediating mechanisms underlying alleged cancer-promoting effects are unknown, including involvement donors' leukocytes, erythrocytes, and soluble factors.Two syngeneic tumor models were used in Fischer 344 rats, MADB106 mammary adenocarcinoma CRNK-16 leukemia. Outcomes included host ability to clear circulating cells, survival rates. The impact was...
In leukemia patients, stress and anxiety were suggested to predict poorer prognosis. Oncological patients experience ample physiological psychological stress, potentially leading increased secretion of factors, including epinephrine, corticosteroids, prostaglandins. Here we tested whether environmental these factors impact survival leukemia-challenged rats, studied mediating mechanisms. F344 rats administered with a miniscule dose 60 CRNK-16 cells, subjected intermittent forced swim or...