A5110173368- Bone Metabolism and Diseases
- Rheumatoid Arthritis Research and Therapies
- Orthopaedic implants and arthroplasty
- Bone health and treatments
- Cell death mechanisms and regulation
- NF-κB Signaling Pathways
- Immune Response and Inflammation
- Osteoarthritis Treatment and Mechanisms
- Bone and Joint Diseases
- Orthopedic Infections and Treatments
- Spondyloarthritis Studies and Treatments
- Inflammatory mediators and NSAID effects
- Oral and gingival health research
- Early Childhood Education and Development
- Cell Adhesion Molecules Research
- Axon Guidance and Neuronal Signaling
- Signaling Pathways in Disease
- Natural Compounds in Disease Treatment
- Bone fractures and treatments
- Hepatitis C virus research
- Angiogenesis and VEGF in Cancer
- Reading and Literacy Development
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Histone Deacetylase Inhibitors Research
- Bee Products Chemical Analysis
The University of Adelaide
2009-2024
Australian Dental Association
2009
Abstract Introduction Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a tumour factor (TNF) family member capable of inducing apoptosis in many cell types. Methods Using immunohistochemistry, terminal deoxynucleotidyl transferase biotin-dUTP nick end labelling (TUNEL) and real-time PCR we investigated the expression TRAIL, TRAIL receptors several key molecules intracellular apoptotic pathway human synovial tissues from various types arthritis normal controls. Synovial...
This study investigated whether the prolonged survival of inflammatory cells in periodontal disease could be due to inhibition apoptosis by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) decoy receptors and terminal stages signaling inhibitor (IAP) family members. Gingival tissue samples were taken from healthy individuals those with chronic periodontitis. The expression TRAIL, TRAIL receptors, TUNEL, cleaved caspase-3, xIAP, survivin was determined immunohistologically at...
TNF-like weak inducer of apoptosis (TWEAK) has been proposed as a mediator inflammation and bone erosion in rheumatoid arthritis (RA). This study aimed to investigate TWEAK receptor (Fn14) expression synovial tissue from patients with active inactive (RA), osteoarthritis (OA) normal controls assess soluble (s)TWEAK levels the fluids RA OA. Effects sTWEAK on osteoclasts osteoblasts were investigated vitro. Fn14 detected tissues by immunohistochemistry (IHC). Selected dual labelled antibodies...
The immunoreceptor tyrosine-based activation motif (ITAM) pathway provides osteoclast co-stimulatory signals and regulates proliferation, survival differentiation of effector immune cells. In the osteoclast, receptors Triggering Receptor Expressed on Myeloid cells 2 (TREM2) Osteoclast Associated (OSCAR) their respective adaptor proteins, DAP12 FcRγ mediate ITAM induce calcium signaling crucial transcription factor, NFATc1. rheumatoid arthritis (RA), OSCAR expression by monocytes is inversely...
Objective . To investigate the effect of Embelin, an inhibitor X‐Linked Inhibitor Apoptosis Protein (XIAP), on inflammation and bone erosion in a collagen antibody induced arthritis (CAIA) mice. Methods Four groups mice ( n = 6 per group) were allocated: CAIA untreated mice, treated with Prednisolone (10 mg/kg/day), low dose Embelin (30 high (50 mg/kg/day). Joint was evaluated using clinical paw score histological assessments. Bone assessed micro‐CT, tartrate resistant acid phosphatase...
Histone deacetylase inhibitors (HDACi) are being considered to treat chronic inflammatory diseases at low doses. Currently HDACi that more specific developed target particular HDACs; therefore, this study aimed determine levels and distribution of class I II HDAC in human gingival samples obtained from patients with periodontitis.Gingival biopsies were without (mild inflammation, no bone loss) periodontitis. Total RNA was isolated for real-time quantitative polymerase chain reaction...
Abstract In rodent models of inflammatory arthritis, bone erosion has been non‐invasively assessed by micro‐computed tomography (micro‐ CT ). However, non‐invasive assessments paw swelling (oedema) are still based on clinical grading visual evaluation, or measurements callipers, not always reliable for the tiny mouse paws. The aim this work was to demonstrate a novel straightforward 3 D micro‐ analysis protocol capable quantifying only joint erosion, but also soft tissue swelling, from same...
The study aimed to determine the effects of parthenolide (PAR) on bone volume (BV) and surface resorption as assessed by live-animal microcomputed tomography (μCT) possible osteocyte death indicated empty lacunae histologically in polyethylene (PE) particle-induced calvarial osteolysis mice. Baseline μCT scans were conducted 7 days preimplantation 2 × 10(8) PE particles/mL over calvariae (day 0). PAR at 1 mg/kg/day was subcutaneously injected 0, 4, 7, 10. At day 14, BV analyzed with μCT....
Abstract This paper explores student and school level factors associated with 15-year-old students’ reading performance in five Southeast Asian (SEA) countries. It investigates predictors of performance, including gender, economic, social, cultural status (ESCS), social well-being, experiences bullying at the level. also sector, climate proportion socioeconomically disadvantaged students school. Using Hierarchical Linear Modelling (HLM), this study identifies significant relationships...