A5060291568- Xenotransplantation and immune response
- Organ Transplantation Techniques and Outcomes
- Pancreatic function and diabetes
- Tissue Engineering and Regenerative Medicine
- Global Health and Surgery
- Animal Genetics and Reproduction
- Virus-based gene therapy research
- Renal Transplantation Outcomes and Treatments
- Travel-related health issues
- Hip and Femur Fractures
- Orthopaedic implants and arthroplasty
- Epigenetics and DNA Methylation
- CRISPR and Genetic Engineering
- Organ Donation and Transplantation
- Cannabis and Cannabinoid Research
- Vascular anomalies and interventions
- Bone and Joint Diseases
- Global Maternal and Child Health
- Cancer Research and Treatments
- Trauma and Emergency Care Studies
- Total Knee Arthroplasty Outcomes
- Mesenchymal stem cell research
- Global Public Health Policies and Epidemiology
- Anesthesia and Neurotoxicity Research
- Urological Disorders and Treatments
Johns Hopkins Medicine
2021-2025
Johns Hopkins University
2021-2025
Columbia University
2022-2023
Johns Hopkins Hospital
2019-2022
Columbia University Irving Medical Center
2022
University of Baltimore
2021
Johns Hopkins Bayview Medical Center
2021
Brown University
2016-2019
Rhode Island Hospital
2017
Nebraska Medical Center
2016
Abstract Xenotransplantation represents a possible solution to the organ shortage crisis and is an imminent clinical reality with long-term xenograft survival in pig-to-nonhuman primate (NHP) heart kidney large animal models, short-term success recent human decedent studies. However, concerns remain about safe translation of these results, given inconsistency published as well key differences between preclinical procurement immunosuppression standards-of-care. Notably, no studies solid...
Xenotransplantation using pig organs is now a clinical reality. However, the process for xenograft recipient screening lacks clarity and scientific rigor: no established thresholds exist to determine which levels of preformed antipig natural antibodies (Nabs) will be safe transplantation, hyperacute rejection (HAR) or acute humoral (AHXR), still impacts pig-to-primate kidney survivals, may impede broader application pig-to-human transplantation.
IntroductionThe interaction of increasing age, Injury Severity Score (ISS), and complications is not well described in geriatric trauma patients. We hypothesized that failure to rescue rate from any complication worsens with age injury severity.MethodsThe National Trauma Data Bank (NTDB) was queried for injured patients aged 65 years or older January 1, 2013 through December 31, 2016. Demographics characteristics were used compare groups. Mortality rates calculated across subgroups ISS,...
<title>Abstract</title> Xenotransplantation (XTx) is an increasingly realistic solution to the organ shortage. Clinical XTx may require off-site procurement in a designated pathogen free (DPF) facility necessitating period of cold ischemic time during transportation. This study evaluates impact different kidney preservation strategies on early graft function pig-to-baboon series eight cases xenotransplantation performed after five hours and compares these results six with minimal time. Our...
Introduction: Xenotransplantation (XTx) is an increasingly realistic solution to the organ shortage. Clinical XTx may require off-site procurement in SPF facility which will lead a period of cold ischemic time during transportation. The aim this study assess effect kidney preservation strategies on early graft function pig-to-baboon XTx. Method: We performed 14 Pig grafts were either GalTKO (n=6) or GalTKO+hCD55 (n=8). 8 cases with 5 hours (preservation group). Graft was preserved using...
Combined islet and kidney xenotransplantation for the treatment of diabetic nephropathy represents a compelling increasingly relevant therapeutic possibility an ever-growing number patients who would benefit from both durable renal replacement cure underlying cause their insufficiency: diabetes. Here we briefly review immune barriers to transplantation, highlight preclinical progress in field, summarize our experience with combined xenotransplantation, including challenges islet-kidney...
Islet transplantation has emerged as a curative therapy for diabetes in select patients but remains rare due to shortage of suitable donor pancreases. using porcine islets long been proposed solution this organ shortage. There have already several small clinical trials humans, results mixed and further limited by calls more rigorous pre-clinical data. Recent progress heart kidney xenograft transplant, including three studies pig-to-human recaptured popular imagination renewed interest islet...
Welcome to Annals of Global Health,Annals Health is a peer-reviewed, fully open access, online journal dedicated publishing high quality articles all aspects global health. The journal's mission advance health, promote research, and foster the prevention treatment disease worldwide. Its goals are improve health well-being people, equity, wise stewardship earth's environment. latest impact factor 3.64.Annals supported by Program for Public Common Good at Boston College. It was founded in 1934...
Abstract Previous studies have demonstrated varying rates of heterotopic ossification (HO) after total hip arthroplasty (THA) depending on which anatomical approach is utilized. The direct anterior (DAA) considered to be a muscle-sparing the hip, may lead decreased HO formation. This study evaluated incidence formation DAA THA. current work retrospective review patients who underwent Six-month postoperative radiographs were and grade was classified using Brooker classification system....
Introduction: Achieving long-term xenograft survival is a major goal. We hypothesize that will be achieved through induction of immune tolerance via co-transplantation the donor thymus. While use pig donors with multiple transgenes has been described in both nonhuman primate (NHP) and brain-dead human models, we can minimal genetic modifications thymokidney approach to induce tolerance. Methods: Six baboons low non-Gal anti-pig natural antibody levels received transplants from...