A5031560506- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Blood Pressure and Hypertension Studies
- Cardiac pacing and defibrillation studies
- Cardiac Imaging and Diagnostics
- Cardiac electrophysiology and arrhythmias
- Acute Myocardial Infarction Research
- Lipoproteins and Cardiovascular Health
- Health Systems, Economic Evaluations, Quality of Life
- Diabetes Treatment and Management
- Hormonal Regulation and Hypertension
- Cardiac Structural Anomalies and Repair
- Potassium and Related Disorders
- Atrial Fibrillation Management and Outcomes
- Renin-Angiotensin System Studies
- Chronic Kidney Disease and Diabetes
- Heart Rate Variability and Autonomic Control
- Antiplatelet Therapy and Cardiovascular Diseases
- Statistical Methods in Clinical Trials
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Health and Disease Prevention
- Cardiac Arrhythmias and Treatments
- Diabetes Management and Research
- Cardiovascular and exercise physiology
- Cardiac Health and Mental Health
Brigham and Women's Hospital
2016-2025
Harvard University
2016-2025
Nuffield Health
2024
National Health and Medical Research Council
2024
University of Glasgow
2002-2023
University of Massachusetts Chan Medical School
2023
Duke-NUS Medical School
2023
British Heart Foundation
2023
Rigshospitalet
2004-2023
Nagoya University
2023
In patients with high cholesterol levels, lowering the level reduces risk of coronary events, but effect levels in majority disease, who have average is less clear.In a double-blind trial lasting five years we administered either 40 mg pravastatin per day or placebo to 4159 (3583 men and 576 women) myocardial infarction had plasma total below 240 deciliter (mean, 209) low-density lipoprotein (LDL) 115 174 139). The primary end point was fatal event nonfatal infarction.The frequency 10.2...
Left ventricular dilatation and dysfunction after myocardial infarction are major predictors of death. In experimental clinical studies, long-term therapy with the angiotensin-converting—enzyme inhibitor captopril attenuated remodeling. We investigated whether could reduce morbidity mortality in patients left a infarction.
Lipid-lowering therapy with statins reduces the risk of cardiovascular events, but optimal level low-density lipoprotein (LDL) cholesterol is unclear.We enrolled 4162 patients who had been hospitalized for an acute coronary syndrome within preceding 10 days and compared 40 mg pravastatin daily (standard therapy) 80 atorvastatin (intensive therapy). The primary end point was a composite death from any cause, myocardial infarction, documented unstable angina requiring rehospitalization,...
This trial was designed to determine whether cardiac-resynchronization therapy (CRT) with biventricular pacing would reduce the risk of death or heart-failure events in patients mild cardiac symptoms, a reduced ejection fraction, and wide QRS complex.During 4.5-year period, we enrolled followed 1820 ischemic nonischemic cardiomyopathy, an fraction 30% less, duration 130 msec more, New York Heart Association class I II symptoms. Patients were randomly assigned 3:2 ratio receive CRT plus...
Angiotensin-converting–enzyme (ACE) inhibitors such as captopril reduce mortality and cardiovascular morbidity among patients with myocardial infarction complicated by left ventricular systolic dysfunction, heart failure, or both. In a double-blind trial, we compared the effect of angiotensin-receptor blocker valsartan, ACE inhibitor captopril, combination two on in this population patients.
Mineralocorticoid-receptor antagonists improve the prognosis for patients with heart failure and a reduced left ventricular ejection fraction. We evaluated effects of spironolactone in preserved fraction.In this randomized, double-blind trial, we assigned 3445 symptomatic fraction 45% or more to receive either (15 45 mg daily) placebo. The primary outcome was composite death from cardiovascular causes, aborted cardiac arrest, hospitalization management failure.With mean follow-up 3.3 years,...
Statins lower the levels of low-density lipoprotein (LDL) cholesterol and C-reactive protein (CRP). Whether this latter property affects clinical outcomes is unknown.
HomeCirculationVol. 113, No. 19AHA/ACC Guidelines for Secondary Prevention Patients With Coronary and Other Atherosclerotic Vascular Disease: 2006 Update
Vitamin K antagonists reduce the risk of stroke in patients with atrial fibrillation but are considered unsuitable many patients, who usually receive aspirin instead. We investigated hypothesis that addition clopidogrel to would vascular events fibrillation.
RAAS Inhibitors in Patients with Covid-19 The effects of renin–angiotensin–aldosterone system blockers on angiotensin-converting enzyme 2 levels and activity humans are uncertain. authors hy...
Selective cyclooxygenase-2 (COX-2) inhibitors have come under scrutiny because of reports suggesting an increased cardiovascular risk associated with their use. Experimental research that these drugs may contribute to a prothrombotic state provides support for this concern.We reviewed all potentially serious events among 2035 patients history colorectal neoplasia who were enrolled in trial comparing two doses celecoxib (200 mg or 400 twice daily) placebo the prevention adenomas. All deaths...
Cardiovascular morbidity and mortality are higher among patients with type 2 diabetes, particularly those concomitant cardiovascular diseases, than in most other populations. We assessed the effects of lixisenatide, a glucagon-like peptide 1-receptor agonist, on outcomes diabetes who had recent acute coronary event.We randomly assigned myocardial infarction or been hospitalized for unstable angina within previous 180 days to receive lixisenatide placebo addition locally determined standards...
The presence of coexisting conditions has a substantial effect on the outcome acute myocardial infarction. Renal failure is associated with one highest risks, but influence milder degrees renal impairment less well defined.As part Valsartan in Acute Myocardial Infarction Trial (VALIANT), we identified 14,527 patients infarction complicated by clinical or radiologic signs heart failure, left ventricular dysfunction, both, and documented serum creatinine measurement. Patients were randomly...
The angiotensin receptor–neprilysin inhibitor sacubitril–valsartan led to a reduced risk of hospitalization for heart failure or death from cardiovascular causes among patients with and ejection fraction. effect inhibition in preserved fraction is unclear.
Background —Elevated plasma concentrations of C-reactive protein (CRP) are associated with increased cardiovascular risk. We evaluated whether long-term therapy pravastatin, an agent that reduces risk, might alter levels this inflammatory parameter. Methods and Results —CRP were measured at baseline 5 years in 472 randomly selected participants the Cholesterol Recurrent Events (CARE) trial who remained free recurrent coronary events during follow-up. Overall, CRP highly correlated ( r =0.60,...
We studied whether inflammation after myocardial infarction (MI) is a risk factor for recurrent coronary events and randomized treatment with pravastatin reduces that risk.A nested case-control design was used to compare C-reactive protein (CRP) serum amyloid A (SAA) levels in prerandomization blood samples from 391 participants the Cholesterol Recurrent Events (CARE) trial who subsequently developed nonfatal MI or fatal event (cases) an equal number of age- sex-matched remained free these...
2][3] More recently, 2 ran-domized controlled trials have evaluated earlier initiation of statin therapy following an ACS event and noted a corresponding early reduction in major cardiovascular events. 5,
To define the relationship between infarct size and ventricular performance, we performed hemodynamic studies in rats 21 days after left coronary artery occlusion. Ventricular performance was assessed under ether anesthesia by measurements of baseline hemodynamics stressed as determined peak cardiac output stroke volume obtained during intravenous loading developed pressure occlusion ascending aorta. Infarct planimetry endocardial circumference each four histological slices ventricle. Rats...