A5058629344- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Multiple Sclerosis Research Studies
- Histone Deacetylase Inhibitors Research
- Cutaneous lymphoproliferative disorders research
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Clostridium difficile and Clostridium perfringens research
- Gastrointestinal motility and disorders
- Gut microbiota and health
- Toxin Mechanisms and Immunotoxins
- Retinoids in leukemia and cellular processes
- Fungal Infections and Studies
City Clinical Hospital
2024
Russian Children's Clinical Hospital
2024
Ministry of Health
2020
Ministry of Health of the Russian Federation
2019-2020
The results of the treatment acute myeloid leukemia (AML) in pediatric patients remain poor. modern programs allow achieving long-term survival only 6570% and event-free rates are lower make up approximately 55%. development protocols for high-intensity therapy, which based on block principle, followed by maintenance therapy has led to significant progress AML. As supportive care improved, it became possible escalate doses chemotherapy, contributed increase effectiveness. So far, drugs...
Fecal microbiota transplantation (FMT) is a promising therapy for variety of diseases involving the gastrointestinal (GI) tract. The purpose our study to evaluate effectiveness FMT treatment different GI complications after allogenic hematopoietic stem cell (steroid-refractory and steroid-dependent graft versus host disease (SR/ SD GVHD) infectious enterocolitis) in children from 1.5 18 years old. was approved by Local Ethics Committee Morozov Children's Clinical Hospital Department Health...
Neuromyelitis optica spectrum disorders (NMOSD) is a general term for immune-mediated diseases of the central nervous system whose phenotype includes affection optic nerve, brainstem encephalitis and myelitis. NMOSD most commonly associated with class G antibodies against aquaporin-4 (aquaporin-4 immunoglobulin G, AQP4-IgG), less glycoprotein myelin oligodendrocytes. There are also seronegative variants NMOSD. The article describes our own experience in treating two boys resistant AQP4-IgG...
The recent chemotherapeutic approaches to acute myeloid leukemia (AML) management reached the limits, achieving overall survival rate of approximately 70 %. An intensification regimens is barely possible due high level toxicity and risk lifethreatening complications. modernization program therapy AML involves clinical application achievements in molecular biology, immunology cytogenetic tumor cell. researches fundamental oncology revealed phases leukemogenesis defined selective ways targeted...
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an extremely rare hematologic malignancy. Our view of the cellular origins this kind tumor has been changing dramatically with emergence new data on molecular biological and immunological characteristics tumor. This article discusses clinical features BPDCN, as well cytological, morphological-immunological genetic criteria for BPDCN diagnosis. Taking into account incidence its rather complex diagnostic procedure, which requires extended...