A5102767701- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Cholinesterase and Neurodegenerative Diseases
- Mitochondrial Function and Pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Biochemical effects in animals
- Protein Tyrosine Phosphatases
- Neurogenesis and neuroplasticity mechanisms
- Tryptophan and brain disorders
- Nuclear Receptors and Signaling
- Medicinal Plants and Neuroprotection
- Peroxisome Proliferator-Activated Receptors
- Alcohol Consumption and Health Effects
- Veterinary medicine and infectious diseases
- Aluminum toxicity and tolerance in plants and animals
- Connexins and lens biology
- Stress Responses and Cortisol
- Photoreceptor and optogenetics research
- Adipose Tissue and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Natural Compound Pharmacology Studies
- Monoclonal and Polyclonal Antibodies Research
- Diabetes and associated disorders
- Receptor Mechanisms and Signaling
- Viral-associated cancers and disorders
Pontificia Universidad Católica de Chile
2011-2024
Advanced Center for Chronic Diseases
2024
Universidad de Magallanes
2020-2021
University of Chile
2018
Fundación Chile
2013
Acetylcholinesterase (AChE; EC 3.1.1.7) plays a crucial role in the rapid hydrolysis of neurotransmitter acetylcholine, central and peripheral nervous system might also participate non-cholinergic mechanism related to neurodegenerative diseases. Alzheimer's disease (AD) is disorder characterized by progressive deterioration cognitive abilities, amyloid-β peptide (Aβ) accumulation synaptic alterations. We have previously shown that AChE able accelerate Aβ assembly into Alzheimer-type...
Alzheimer’s disease (AD) is a neurodegenerative disorder in which the amyloid-β (Aβ) oligomers are key factor synaptic impairment and spatial memory decline associated with neuronal dysfunction. This includes failure loss of proteins that contribute to AD progression. Interestingly, use natural compounds an emergent conceptual strategy search for drugs therapeutic potentials treating disorders. In present study, we report andrographolide (ANDRO), labdane diterpene extracted from Andrographis...
Recent studies showed that the activation of retinoid X receptor, which dimerizes with peroxisome proliferator-activated receptors (PPARs), leads to an enhanced clearance Aβ from brain transgenic mice model Alzheimer's disease (AD), because increased expression apolipoprotein E and it main transporters. However, effects observed must involve additional underlying mechanisms have not been yet explored. Several conducted in our laboratory suggest part for PPARs agonist might involves...
Astrocytes release gliotransmitters via connexin 43 (Cx43) hemichannels into neighboring synapses, which can modulate synaptic activity and are necessary for fear memory consolidation. However, the released, their mechanisms of action remain elusive. Here, we report that conditioning training elevated Cx43 hemichannel in astrocytes from basolateral amygdala (BLA). The selective blockade by microinfusion TAT-Cx43L2 peptide BLA induced deficits 1 24 h after training, without affecting...
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive deterioration of cognitive abilities, amyloid-β peptide (Aβ) accumulation and synaptic alterations. Previous studies indicated that hyperforin, component the St John's Wort, prevents Aβ neurotoxicity some behavioral impairments in rat model AD. In this study we examined ability tetrahydrohyperforin (IDN5607), stable hyperforin derivative, to prevent deficit impairment an vivo double transgenic...
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive deterioration of cognitive abilities, accumulation the amyloid-β peptide (Aβ), increase oxidative stress, and synaptic alterations. The scavenging reacti
Alzheimer's disease (AD) is the most common neurodegenerative disorder and leading cause of age-related dementia worldwide. Several models for AD have been developed to provide information regarding initial changes that lead degeneration. Transgenic mouse recapitulate many, but not all, features AD, likely because high complexity pathology. In this context, validation a wild-type animal model mimics neuropathological behavioral abnormalities necessary. previous studies, we reported Chilean...
The role of ventral hippocampus (vHipp) astroglial gliotransmission in depression was studied using chronic restraint stress (CRS) and unpredictable mild (CUMS) rodent models. CRS increased Cx43 hemichannel activity extracellular glutamate levels the vHipp blocking hemichannel-dependent during prevented development buildup. Moreover, acute blockade hemichannels induced antidepressant effects rats previously subjected to or CUMS. This effect by coinjection D-serine. Furthermore, decreased...
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive deterioration of cognitive abilities, amyloid-β peptide (Aβ) accumulation, neurofibrillary tangle deposition, synaptic alterations, and oxidative injury. In AD patients, acetylcholinesterase (AChE) activity low in most regions the brain, but increased within around amyloid plaques, where it accelerates Aβ assembly into oligomers fibrils, increasing its neurotoxicity. Tetrahydrohyperforin (THH),...
Traumatic Brain Injury (TBI) mediates neuronal death through several events involving many molecular pathways, including the glutamate-mediated excitotoxicity for excessive stimulation of N-methyl-D-aspartate receptors (NMDARs), producing activation signaling pathways. However, contribution NMDARs (distribution and signaling-associated to distribution) remains incompletely understood. We propose a critical role STEP61 (Striatal-Enriched protein tyrosine phosphatase) in TBI; this phosphatase...
Alzheimer's disease (AD) is a neurodegenerative disorder in which the amyloid-β (Aβ) peptide plays key role synaptic impairment and memory decline associated with neuronal dysfunction intra-neuronal accumulation of hyperphosphorylated tau protein. Two novel enantiopure rhein-huprine hybrids ((+)-1 (-)-1) exhibit potent inhibitory effects against human acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), BACE-1 both Aβ antiaggregation activity vitro reduction on amyloid precursor...
St. John's wort has been the subject of studies focused on its therapeutic properties against several diseases, including Alzheimer's disease (AD). Amyloid β-peptide (Aβ), a critical peptide in AD, linked to mitochondrial dysfunction oft
Cognitive dysfunction (CD) is common among patients with the autoimmune disease systemic lupus erythematosus (SLE). Anti-ribosomal P autoantibodies associate this and have neuropathogenic effects that are mediated by cross-reacting neuronal surface antigen (NSPA) protein. Elucidating function of NSPA can then reveal CD pathogenic mechanisms treatment opportunities. In brain, somehow contributes to glutamatergic NMDA receptor (NMDAR) activity in synaptic plasticity memory. Here we analyze...
Background: Epstein–Barr virus (EBV) is involved in the development of lymphomas, nasopharyngeal carcinomas (NPC), and a subgroup gastric (GC), has also been detected lung carcinomas, even though role this malignancy not yet established. BamH1-A Rightward Frame 1 (BARF1), suggested exclusive epithelial EBV oncoprotein, both EBV-associated GCs (EBVaGC) NPC. The expression BARF1 cancer unknown. Methods: A total 158 including 80 adenocarcinomas (AdCs) 78 squamous cell (SQCs) from Chilean...
<h3>Background</h3> Anti-ribosomal P protein autoantibodies (anti-P) are found in 10%–15% of all patients with lupus<sup>1</sup> and their pathogenic role is supported by clinical studies showing association psychosis<sup>2</sup> cognitive deficit,<sup>3</sup> as well experiments rodents depression like behaviour,<sup>4</sup> memory impairment<sup>5</sup> electrophysiological alterations.<sup>6, 7</sup> The Neuronal Surface Antigen (NSPA) identified an anti-P cross-reacting...