Leah Bush

ORCID: 0000-0003-3882-3793
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About
Contact & Profiles
Research Areas
  • Sulfur Compounds in Biology
  • Cannabis and Cannabinoid Research
  • Biochemical effects in animals
  • Neuroscience of respiration and sleep
  • Retinal Development and Disorders
  • Cardiac electrophysiology and arrhythmias
  • Autoimmune and Inflammatory Disorders Research
  • Helicobacter pylori-related gastroenterology studies
  • Forensic Toxicology and Drug Analysis
  • Inflammasome and immune disorders
  • Robotic Mechanisms and Dynamics
  • Atrial Fibrillation Management and Outcomes
  • Immune Cell Function and Interaction
  • Gastrointestinal motility and disorders
  • Advanced MRI Techniques and Applications
  • Neurological Disorders and Treatments
  • Experimental Learning in Engineering
  • Migration, Ethnicity, and Economy
  • melanin and skin pigmentation
  • Obstructive Sleep Apnea Research
  • Thermoregulation and physiological responses
  • Animal Nutrition and Health
  • Cardiovascular Effects of Exercise
  • Alcohol Consumption and Health Effects
  • Dye analysis and toxicity

Texas Southern University
2016-2025

Nationwide Children's Hospital
2024

Prairie View A&M University
2020

Both hydrogen sulfide and endocannabinoids can protect the neural retina from toxic insults under in vitro vivo conditions. Purpose: The aim of present study was two-fold: (a) to examine neuroprotective action cannabinoids [methanandamide 2-arachidonyl glycerol (2-AG)] against peroxide (H2O2)-induced oxidative damage isolated bovine (b) evaluate role endogenously biosynthesized (H2S) inhibitory actions on stress retina. Methods: Isolated retinas cows were exposed using H2O2 (100 µM) for 10...

10.3390/ph18010117 article EN cc-by Pharmaceuticals 2025-01-17

Purpose: To investigate the pharmacological actions of hydrogen sulfide (H2S)-releasing compounds l-cysteine and sodium hydrosulfide (NaHS) on aqueous humor (AH) outflow facility in porcine ocular anterior segment. Methods: Porcine segments were perfused with Dulbecco's modified Eagle's medium at a constant pressure 7.35 mmHg. After stable baseline, explants exposed to NaHS or l-cysteine. The increase generated by H2S-releasing was measured absence presence inhibitor H2S biosynthesis...

10.1089/jop.2016.0037 article EN Journal of Ocular Pharmacology and Therapeutics 2017-01-18

Abstract For reasons poorly understood, and despite the availability of biological medications blocking IL-1 IL-6 that have markedly improved overall disease control, children with Systemic Juvenile Idiopathic Arthritis (SJIA) are now increasingly diagnosed life-threatening chronic complications, including hepatitis lung (SJIA-LD). On October 3–4, 2019, a two-day meeting, NextGen Therapies for & macrophage activation syndrome (MAS ) organized by JIA Foundation ( www.systemicjia.org/ in...

10.1186/s12969-020-00444-7 article EN cc-by Pediatric Rheumatology 2020-07-01

We have further defined the binding characteristics of [3H]nitrendipine to myocardial microsomal membranes cats, dogs, rats, and rabbits canine coronary vasculature (1.5-3.0 mm OD), we studied nitrendipine's effect on contractile responses in isolated feline cardiac muscle arteries. is rapid, saturable, reversible all four species these tissues. Feline myocardium has a single site with dissociation constant (KD) 1.94 nM. Canine may two classes sites, high-affinity having KD 0.17 Nitrendipine...

10.1152/ajpheart.1984.247.5.h775 article EN AJP Heart and Circulatory Physiology 1984-11-01

Both endocannabinoids and hydrogen sulfide (H2S) can exert neuroprotective actions against toxic insults in retinal tissues both vitro vivo. The aim of the present study was two fold: (a) to investigate role H2S action cannabinoids oxidative stress bovine isolated retina (b) examine pharmacological effect on production this tissue.

10.1254/jpssuppl.wcp2018.0_po2-1-60 article EN Proceedings for Annual Meeting of The Japanese Pharmacological Society 2018-01-01

Caffeine/Coffee consumption has been reported to increase the thermic effects of food and fat oxidation (Acheson et al., Am. J. Clin. Nutr. 33: 989, 1980) can cause weight loss in obese subjects (Westerterp‐Plantenga Physiol. Behav. 89:85, 2006). Purpose Since serotonin (5‐hydroxytryptamine, 5‐HT) implicated regulation feeding behavior, aim present study was determine effect extract green coffee bean (GCBE) on uptake radiolabeled ([ 3 H]‐5‐HT) rat brain cortex. Methods Isolated cortex slices...

10.1096/fasebj.30.1_supplement.lb508 article EN The FASEB Journal 2016-04-01

Both endocannabinoids and hydrogen sulfide (H 2 S) have been reported to exert neuroprotective actions in neural tissues ( Biermann et al., Mol Vis. 2011;17:1275–86; Nucci Invest Ophthalmol Vis Sci. 2007;48(7):2997–3004 ). It remains be determined if these modulators can interact with each other and/or share a common pathway their actions. Purpose The aim of the present study was, therefore, investigate pharmacological on biosynthesis H S isolated bovine retina. Methods Isolated retinae were...

10.1096/fasebj.2018.32.1_supplement.825.12 article EN The FASEB Journal 2018-04-01

10.1016/s0022-2828(86)80633-2 article EN Journal of Molecular and Cellular Cardiology 1986-01-01
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