A5101479933- Cystic Fibrosis Research Advances
- Melanoma and MAPK Pathways
- Neonatal Respiratory Health Research
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Skin Protection and Aging
- Legume Nitrogen Fixing Symbiosis
- International Maritime Law Issues
- Chronic Lymphocytic Leukemia Research
- Marine and fisheries research
- Acute Lymphoblastic Leukemia research
- Tissue Engineering and Regenerative Medicine
- Balance, Gait, and Falls Prevention
- Membrane Separation Technologies
- Coastal and Marine Management
- Genomics and Rare Diseases
- Asthma and respiratory diseases
- Photodynamic Therapy Research Studies
- Botulinum Toxin and Related Neurological Disorders
- Multiple Myeloma Research and Treatments
- Cutaneous Melanoma Detection and Management
- Cellular transport and secretion
University of Lisbon
2013-2024
Hospital de Santa Maria
2016
Instituto de Medicina Molecular João Lobo Antunes
2016
Trafficking of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein is a complex process that starts with its biosynthesis and folding in endoplasmic reticulum. Exit from reticulum (ER) coupled acquisition compact structure can be processed traffic through secretory pathway. Once reaching final destination—the plasma membrane, CFTR stability regulated interaction multiple partners are involved post-translation modification, connecting channel to several signaling pathways....
Cystic Fibrosis (CF), the most common lethal autosomic recessive disorder among Caucasians, is caused by mutations in gene encoding Transmembrane conductance Regulator (CFTR) protein, a cAMP-regulated chloride channel expressed at apical surface of epithelial cells. Cyclic AMP regulates both CFTR gating through protein kinase A (PKA)-dependent process and plasma membane (PM) stability activation exchange directly activated cAMP1 (EPAC1). This cAMP effector, when promotes NHERF1:CFTR...
According to some authors, the phototoxic response ultraviolet A (UVA) of patients treated with vemurafenib (VB) may involve VB metabolites. However, production singlet oxygen and free radicals photoproduct formation upon UVA light absorption by lipophilic have been demonstrated. This work is aimed at determining contribution reactive species (ROS), lipid photoperoxidation, photochemistry in UVA-induced photocytotoxicity NCTC 2544 keratinocytes. The potent membrane peroxidation effectiveness...
The plasma membrane (PM) stability of the cystic fibrosis transmembrane conductance regulator (CFTR), protein which when mutated causes Cystic Fibrosis (CF), relies on multiple interaction partners that connect CFTR to signaling pathways, including cAMP signaling. It was previously shown activation exchange directly activated by 1 (EPAC1) promotes an increase in PM levels airway epithelial cells. However, relevance this pathway other tissues, particularly intestinal tissue, remains...