A5102750029- Hematopoietic Stem Cell Transplantation
- Helicobacter pylori-related gastroenterology studies
- Galectins and Cancer Biology
- Grief, Bereavement, and Mental Health
- Multiple Myeloma Research and Treatments
- Bacteriophages and microbial interactions
- Acute Lymphoblastic Leukemia research
- Social and Educational Sciences
- Plant Virus Research Studies
- Education, Healthcare and Sociology Research
- Eosinophilic Esophagitis
- Acute Myeloid Leukemia Research
- Cancer Treatment and Pharmacology
- Polyomavirus and related diseases
- Microbial Community Ecology and Physiology
- Viral Infections and Vectors
- Chemotherapy-induced organ toxicity mitigation
- Automotive and Human Injury Biomechanics
- Counseling, Therapy, and Family Dynamics
- SARS-CoV-2 detection and testing
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Immune Cell Function and Interaction
- Enhanced Recovery After Surgery
- Academic and Historical Perspectives in Psychology
- Burkholderia infections and melioidosis
Örebro University
2017-2022
Örebro University Hospital
2022
Genome Institute of Singapore
2008-2011
Karolinska Institutet
2003-2010
UNSW Sydney
2010
Swedish Institute
2003-2010
National Clinical Research
2007
Karolinska University Hospital
1999-2006
Stockholm University College of Music Education
2002-2003
Göteborgs Stads
2001
Reclaimed water use is an important component of sustainable resource management. However, there are concerns regarding pathogen transport through this alternative supply. This study characterized the viral community found in reclaimed and compared it with viruses potable water. contained 1000-fold more virus-like particles than water, having approximately 10(8) VLPs per millilitre. Metagenomic analyses revealed that most both were novel. Bacteriophages dominated DNA but had a distinct phage...
Viruses are the most abundant and diverse genetic entities on Earth; however, broad surveys of viral diversity hindered by lack a universal assay for viruses inability to sample sufficient number individual hosts. This study utilized vector-enabled metagenomics (VEM) provide snapshot DNA present in three mosquito samples from San Diego, California. The majority sequences were novel, suggesting that community mosquitoes, as well animal plant hosts they feed on, is highly largely...
Certain environmental microorganisms can cause severe human infections, even in the absence of an obvious requirement for transition through animal host replication (“accidental virulence”). To understand this process, we compared eleven isolate genomes Burkholderia pseudomallei (Bp), a tropical soil microbe and causative agent disease melioidosis. We found evidence existence several new genes Bp reference genome, identifying 282 novel supported by at least two independent lines supporting...
ABSTRACT Helicobacter pylori infection is associated with a variety of outcomes ranging from seemingly asymptomatic coexistence to peptic ulcer disease and gastric cancer. The cag pathogenicity island (PAI) contains genes more aggressive phenotype has been suggested be determinant severe outcome. cagA gene served as marker for the PAI. However, presence this single does not necessarily indicate complete set PAI genes. We have analyzed composition in 66 clinical isolates obtained patients...
A large number of genes encoding restriction-modification (R-M) systems are found in the genome human pathogen Helicobacter pylori. R-M comprise approximately 10% strain-specific genes, but relevance having such an abundance these is not clear. The type II methyltransferase (MTase) M.HpyAIV, which recognizes GANTC sites, was present 60% H. pylori strains analyzed, whereof 69% were resistant to restriction enzyme digestion, indicated presence active MTase. with inactive M.HpyAIV phenotype...
Abstract: The pharmacokinetics of cyclophosphamide (CP) and its cytotoxic metabolite 4‐hydroxycyclophosphamide (4‐OHCP) have been studied in multiple myeloma patients treated with the CIB (CP, interferon‐α (IFN‐α) betamethasone) regimen. In present investigation we aimed to determine whether exposure CP 4‐OHCP is influenced by concomitant administration IFN‐α. Ten previously untreated entered study. Each patient received two courses randomized order. Interferon was administered either 2 h...
An Effort to Make All the Pieces Come Together: Women's Long-Term Perspectives on Their Experiences of Intense Fear Childbirth
• Feelings of inadequacy as personal faced the survivors' emotional storm and despair. Personal made attempts to shield themselves also survivors. decision focus on survivors give time be accessible. They were uncertainty about responsibility felling torn in professional role. The professionals need organisational guidelines ethical support.
The authors report a possible interaction between ketobemidone and busulfan during myeloablative treatment of patient with acute myeloid leukemia. At the time admission, was receiving 1,000 mg/d as analgesic for rectal fissure. started conditioning prior to bone marrow transplantation (1 mg/kg × 4 days). High plasma concentrations were observed after first dose next doses reduced 0.7 mg/kg. kinetics both drugs revealed that an increase in concentration followed by levels. Substituting...
Purpose The aim of the study was to describe loss a family member by suicide, based on lived experience suicide survivors.Methods A phenomenology with Reflective Lifeworld Research approach conducted, consisting sixteen interviews eight survivors.Results essence losing encompasses experiences involuntary and existential loneliness, life suffering, additional burdens in that is radically transformed, comprising prolonged energy-intensive attempts understand. Life for constant fear being...
Abstract Purpose: The prodrug cyclophosphamide (CPA) is activated by cytochrome P450 (CYP) enzymes. CPA one of the corner stones in all cancer treatment. We have studied effect repeated doses given at different time intervals on mRNA, protein levels, and enzyme activity CYPs rats. Experimental Design: Two groups animals (A-75 A-150) were treated with four (75 150 mg/kg, respectively) short (6 h). third group (B-150) was mg/kg 24-h intervals. Three killed 30 min after administration, three...
Background: Recent epidemics have underscored the importance of non-human viral reservoirs and devastating impact emerging viruses on human health. Broad understanding animal circulating in a given region is crucial for monitoring diseases, but hindered by inability to sample enough individuals difficulty characterizing previously undescribed viruses. As mosquitoes draw blood from animals humans are known carry number viruses, metagenomic sequencing particles purified enables surveillance...
Many professions involving relational work as an essential component – such nurses, social workers and psychotherapists are currently challenged by a growing demand on so-called "evidence-based" methods. In the debate, professional practioners from these fields have repeatedly voiced complaint that there crucial aspects of knowledge involved in their do not fit into this paradigm. Their Professional abilities, they claim, include kind might be "scientific" or "evidence-based", but is still...