A5046925220- Autoimmune Neurological Disorders and Treatments
- Neuroscience and Neuropharmacology Research
- Genetics and Neurodevelopmental Disorders
- Vaccine Coverage and Hesitancy
- Diphtheria, Corynebacterium, and Tetanus
- Boron Compounds in Chemistry
- Molecular Sensors and Ion Detection
- Neuroinflammation and Neurodegeneration Mechanisms
- Amino Acid Enzymes and Metabolism
- Infectious Encephalopathies and Encephalitis
- Luminescence and Fluorescent Materials
- Intramuscular injections and effects
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2022-2025
Fundació Clínic per a la Recerca Biomèdica
2024
Universitat Autònoma de Barcelona
2018
A series of novel fluorescent BODIPY-anionic boron cluster conjugates bearing [B12H12]2– (5, 6), [3,3′-Co(1,2-C2B9H11)2]− (7, 8), and [3,3′-Fe(1,2-C2B9H11)2]− (9) anions have been readily synthesized from meso-(4-hydroxyphenyl)-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY 4), their structure photoluminescence properties assessed. Linking anionic clusters to the BODIPY (4) does not alter significantly luminescent final fluorophores, showing all them similar emission quantum yields...
Abstract Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a disorder mediated by autoantibodies against the GluN1 subunit of NMDAR. It occurs with severe neuropsychiatric symptoms that often improve immunotherapy. Clinical studies and animal models based on patients’ antibody transfer or NMDAR immunization suggest play major pathogenic role. Yet, there an important need offering all-inclusive neuro-immunobiology disease together clinical course long enough to facilitate assessment...
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a disorder mediated by autoantibodies against the GluN1 subunit of NMDAR. It occurs with severe neuropsychiatric symptoms that often improve immunotherapy. Clinical studies and animal models based on patients' antibody transfer or NMDAR immunization suggest play major pathogenic role. Yet, there an important need offering all-inclusive neuro-immunobiology disease together clinical course long enough to facilitate assessment potential...
Abstract N-methyl D-aspartate receptor (NMDAR) encephalitis is an immune-mediated disorder characterized by a complex neuropsychiatric syndrome together with reduction of NMDAR. Although in most patients the life-threatening symptoms acute stage resolve immunotherapy, memory and executive functions remain altered for several months or years. A mechanistic explanation these long-lasting cognitive effects still lacking previous animal models have not explored this effect. Here, we combined...