A5103080422- Retinal Development and Disorders
- Photoreceptor and optogenetics research
- Neuroscience and Neural Engineering
- Neuroscience and Neuropharmacology Research
- Connexins and lens biology
- Analytical Chemistry and Sensors
- Cellular Mechanics and Interactions
- Receptor Mechanisms and Signaling
- Photochromic and Fluorescence Chemistry
- melanin and skin pigmentation
University of Louisville
2014-2019
Friedrich-Alexander-Universität Erlangen-Nürnberg
2013
Throughout the CNS, interactions between pre- and postsynaptic adhesion molecules establish normal synaptic structure function. Leucine-rich repeat (LRR) domain-containing proteins are a large family that has diversity of ligands, their absence can cause disease. At first retinal synapse, LRIT3 expression leads to disassembly glutamate signaling complex (signalplex) expressed on depolarizing bipolar cell (DBC) dendrites. The prevalent view is assembly signalplex results from direct...
Objective. In clinical trials, retinitis pigmentosa patients implanted with a retinal prosthetic device show enhanced spatial vision, including the ability to read large text and navigate. New prosthetics aim increase resolution by decreasing pixel/electrode size limiting current spread. To examine of new design, we characterized compared two photovoltaic array (PVA) designs their interaction retina after subretinal implantation in transgenic S334ter line 3 rats (Tg S334ter-3). Approach....
ABSTRACT At its first synapse, the retina establishes two parallel channels that encode light increments (ON) or decrements (OFF). same changes in photoreceptor glutamate release are sensed by ON bipolar cells (BCs) via metabotropic receptor 6 (mGluR6), and OFF BCs ionotropic BCs, which differ their synaptic configuration with terminal. form invaginating synapses bring them close proximity to presynaptic ribbons presumed sole source of release. flat contacts distal ribbon synapse. We...
Abstract Congenital nystagmus, involuntary oscillating small eye movements, is commonly thought to originate from aberrant interactions between brainstem nuclei and foveal cortical pathways. Here we investigated whether nystagmus associated with congenital stationary nightblindness (CSNB) can result primary deficits in the retina. We found that CSNB patients as well an animal model ( nob mice), both of which lack functional nyctalopin protein (NYX, nyx) ON bipolar cells (ON-BC) at their...
Synaptic function requires the precise alignment of pre and post-synaptic signaling complexes. At first synapse in retina, each rod photoreceptor connects via an invaginating ribbon to two postsynaptic partners, bipolar cells (RBCs) horizontal (HCs) cells. The RBCs signal rod-mediated changes synaptic glutamate using a signalplex initiated by metabotropic receptor 6, mGluR6, culminating with modulation transient potential cation channel, melastatin subfamily 1 (TRPM1) channel. One member...