A5052687185- Advanced Drug Delivery Systems
- Chemical Synthesis and Analysis
- Nanoparticle-Based Drug Delivery
- Antimicrobial Peptides and Activities
- Antimicrobial agents and applications
- Supramolecular Self-Assembly in Materials
- Lipid Membrane Structure and Behavior
- Nonlinear Optical Materials Studies
- Alzheimer's disease research and treatments
- RNA Interference and Gene Delivery
- Bone and Dental Protein Studies
- Cellular transport and secretion
- Advanced Sensor and Energy Harvesting Materials
- Polydiacetylene-based materials and applications
- Biochemical and Structural Characterization
- Neuroscience of respiration and sleep
- Microtubule and mitosis dynamics
- Epilepsy research and treatment
- Photochromic and Fluorescence Chemistry
- Drug Solubulity and Delivery Systems
- Advancements in Transdermal Drug Delivery
- Anesthesia and Pain Management
- Neonatal Respiratory Health Research
- Luminescence and Fluorescent Materials
- Polymer Surface Interaction Studies
UNSW Sydney
2015-2024
The University of Sydney
2021
University of Technology Sydney
2018-2020
The development of functional nanocoatings using natural compounds is a hallmark sustainable strategies in the field green synthesis. Herein, we report surface-independent nanocoating strategy polyphenols and gallium-based room temperature liquid metal nanoparticles. matrix composed tannic acid, crosslinked with group (IV) transition ions. Liquid gallium nanoparticles are incorporated into coatings as ion releasing depot. coating deposition rapid can be applied to range substrates including...
Addition of water triggers gelation in (poly)ethylene glycol (PEG) solutions peptide gelators, with or without drugs added. The gels are formed by a combination macromolecular crowding and hydrophobic effects as evident significant secondary structure changes when compared to gel from pure water.
There is a significant and urgent need for the development of novel antibacterial agents to tackle increasing incidence antibiotic resistance. Cholic acid-based small molecular antimicrobial peptide mimics are reported as potential new leads treat bacterial infection. Here, we describe design, synthesis biological evaluation cholic mimics. The acid analogues involves attachment hydrophobic moiety at carboxyl terminal scaffold, followed by installation one three amino residues on hydroxyl...
This article describes a new approach in targeted drug delivery to the central nervous system (CNS) significant departure from predominant systematic administration attempting penetrate blood–brain barrier (BBB). Nanoparticles chemically conjugated neural tract tracer proteins are capable of path-specific axonal retrograde transport, transneuronal and anatomical flow bypass BBB. To celebrate work by Dr. Bettye Washington Greene on physical chemistry colloidal particles, this focuses...
Paclitaxel (PTX) and 5-fluorouracil (5-FU) are clinically relevant chemotherapeutics, but both suffer a range of biopharmaceutical challenges (e.g., either low solubility or permeability limited controlled release from nanocarriers), which reduces their effectiveness in new medicines. Anticancer drugs have several major limitations, include non-specificity, wide biological distribution, short half-life, systemic toxicity. Here, we investigate the potential liposome-micelle-hybrid (LMH)...
There has been an increasing interest in the development of antimicrobial peptides (AMPs) and their synthetic mimics as a novel class antibiotics to overcome rapid emergence antibiotic resistance. Recently, phenylglyoxamide-based small molecular AMP have identified potential leads treat bacterial infections. In this study, new series biphenylglyoxamide-based were synthesised from ring-opening reaction N-sulfonylisatin bearing biphenyl backbone with diamine, followed by conversion into...
Neural tracing proteins like horseradish peroxidase-conjugated wheat germ agglutinin (WGA-HRP) can target the central nervous system (CNS) through anatomic retrograde transport without crossing blood-brain barrier (BBB). Conjugating WGA-HRP to nanoparticles may enable creation of BBB-bypassing nanomedicine. Microfluidics and two-photon confocal microscopy is applied screen nanocarriers for efficacy gain mechanistic insights into their interactions with neurons. Protein modification gold...
The rapid emergence of drug-resistant bacteria is a major global health concern. Antimicrobial peptides (AMPs) and peptidomimetics have arisen as new class antibacterial agents in recent years an attempt to overcome antibiotic resistance. A library phenylglyoxamide-based small molecular was synthesised by incorporating N-alkylsulfonyl hydrophobic group with varying alkyl chain lengths hydrophilic cationic into glyoxamide core appended phenyl ring systems. quaternary ammonium iodide salts 16d...
Respiratory dysfunction is a major cause of death in people with spinal cord injury (SCI). A remaining unsolved problem treating SCI the intolerable side effects drugs to patients. In significant departure from conventional targeted nanotherapeutics overcome blood-brain barrier (BBB), this work pursues drug-delivery approach that uses neural tracing retrograde transport proteins bypass BBB and deliver an adenosine A1 receptor antagonist drug, 1,3-dipropyl-8-cyclopentyl xanthine, exclusively...
Abstract A small library of short peptides has been synthesized based upon the repeat tetrapeptide sequence Gly‐Val‐Ala‐Pro (GVAP) which is found in hydrophobic domain tropoelastin. Of five synthesized, four formed self‐supporting hydrogels with similar secondary structures. The ability to tune mechanical properties resultant was demonstrated, and this understood relation fiber bundling. Finally, cytotoxicity these elastin‐based peptide towards HeLa cells assessed, clear evidence that...
Effects of the Adenosine A1 blockade using 8-cyclopentyl-1,3-diprophyxanthine (DPCPX) nanoconjugate on inducing recovery hemidiaphragm paralyzed by hemisection have been thoroughly examined previously; however, toxicology DPCPX remains unknown. This research study investigates therapeutic efficacy and in cervical spinal cord injury (SCI) rat model. We hypothesized that a single injection left (LDH) hemisected rats at 2nd segment (C2Hx) would lead to long-term LDH while showing minimal...