In this paper, UNIPIC code, a new member in the family of fully electromagnetic particle-in-cell (PIC) codes for simulations high power microwave (HPM) generation, is introduced. fields are updated using second-order, finite-difference time-domain (FDTD) method, and particles moved relativistic Newton–Lorentz force equation. The convolutional perfectly matched layer method used to truncate open boundaries HPM devices. To model curved surfaces avoid time step reduction conformal-path FDTD CP...

In photoswitches that undergo fluorescence switching upon ultraviolet irradiation, photoluminescence and photoisomerization often occur simultaneously, leading to unstable properties. Here, we successfully demonstrated reversible solid-state triple through "Pump-Trigger" multiphoton manipulation. A novel photoswitch, BOSA-SP, achieved green, yellow, red under excitation by pump light isomerization induced trigger light. The energy ranges of photoexcitation did not overlap, enabling...

The gene desert upstream of the MYC oncogene on chromosome 8q24 contains susceptibility loci for several major forms human cancer. region shows high conservation between and mouse multiple enhancers that are activated in tumor cells. However, role this normal development has not been addressed. Here we show a 538 kb deletion entire super-enhancer mice results 50% to 80% decrease Myc expression tissues. viable no overt phenotype. they resistant tumorigenesis, most cells isolated from them...

The graphitic carbon nitride (g-C3N4) nanosheets decorated three-dimensional hierarchical flower-like nickel oxide (NiO) composites (NiO/g-C3N4, Ni/CN) were synthesized via a facile hydrothermal method combined with subsequent annealing process. structure and morphology of the as-prepared Ni/CN characterized by X-ray diffraction, field-emission scanning electron microscopy, transmission photoelectron spectroscopy, nitrogen absorption. gas-sensing experiments reveal that 10 wt %...

A klystron-like relativistic backward wave oscillator with a ratio of transverse dimension to free-space wavelength being about four is presented. In the beam-wave interaction region, electron beam interacts surface and volume simultaneously. The cathode holder plays an important role in reflection waves. guard electrode, collector ring, ring are used optimize interaction. particle cell simulation results reveal that microwaves power 2 GW frequency 12.3 GHz generated efficiency 42% when...

A dual-mode operation mechanism in an overmoded relativistic backward wave oscillator is presented. The electron beam interacts with the −1st space harmonic of TM01 mode synchronously slow structure. Then propagating converted to forward TM02 mode. As phase velocity volume about twice that surface mode, also plays important role high-power microwave generation. Particle-in-cell simulation shows efficiency 48% and a significant improvement power capacity have been obtained.

Abstract Human papillomavirus type 16 (HPV-16) 5′-splice site SD3632 is used exclusively to produce late L1 mRNAs. We identified a 34-nt splicing inhibitory element located immediately upstream of HPV-16 SD3632. Two AUAGUA motifs in these 34 nt inhibited nucleotide substitutions each the specific alleviated inhibition and induced mRNA production from episomal forms genome primary human keratinocytes. The bind specifically not only heterogeneous nuclear RNP (hnRNP) D family RNA-binding...

A high power microwave (HPM) device packaged with permanent magnet is realized experimentally based on a relativistic backward wave oscillator (RBWO). The experimental results show that the frequency of Ku-band 16.15 GHz and 1.06 GW an efficiency about 25% in case which diode voltage 620 kV, beam current 6.9 kA, guiding magnetic flux density 0.94 T. result continuous operation for 1 s at repetition rate 50 Hz indicates RBWO can operate rate.

Preliminary experimental results of a repetitive 0.14 THz overmoded relativistic surface wave oscillator (RSWO) are presented in this paper. The RSWO is developed by using rectangularly corrugated slow-wave structure with ratio 3 and foilless diode emitting annular electron beam thickness 0.5 mm. high quality beams at the repetition rate 10 obtained over wide range voltage (180 kV < U 240 kV) current (700 A I 1.2 kA). generation experiments conducted an axial pulsed magnetic field...

Experimental study on high-power subterahertz waves generated by an overmoded surface wave oscillator (SWO) is carried out in this paper. With accurate fabrication and assembly, the frequency obtained 0.148 THz as measured cut-off waveguide subharmonic heterodyne methods, output power about 5 MW with far-field measurement method at a diode voltage of 300 kV, beam current 2.3 kA, guiding magnetic field T. The device remains fairly stable when changes from 200 to 330 kV. This typical feature...

The most commonly used 3′-splice site on the human papillomavirus type 16 (HPV-16) genome named SA3358 is to produce HPV-16 early mRNAs encoding E4, E5, E6 and E7, late L1 L2. We have previously shown that suboptimal totally dependent a downstream splicing enhancer containingmultiple potential ASF/SF2 binding sites. Here weshow only one of predicted sites accounts for majority activity. demonstrate single nucleotide substitutions in this impair function correlates with less efficient vitro....

Isobutyryl-CoA dehydrogenase deficiency (IBDD) is a rare autosomal recessive disorder caused by biallelic variants in the ACAD8 gene, which disrupts valine metabolism. In this study, we report seven individuals identified through newborn screening (NBS) with elevated C4-acylcarnitine levels, including five confirmed patients and two heterozygous carriers. Genetic analysis 12 distinct variants, of were novel (c.221C>T, c.518T>C, c.727A>G, c.868G>A, c.947A>T, c.966G>A, c.1058T>C). According to...

Views Icon Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Twitter Facebook Reddit LinkedIn Tools Reprints and Permissions Cite Search Site Citation Hai Zhang, Jianguo Wang, Changjiang Tong, Xiaoze Li, Guangqiang Wang; Numerical studies of powerful terahertz pulse generation from a super-radiant surface wave oscillator. Phys. Plasmas 1 December 2009; 16 (12): 123104. https://doi.org/10.1063/1.3263260 Download citation file: Ris (Zotero) Reference Manager...

Two splice sites on the human papillomavirus type 16 (HPV-16) genome are used exclusively by late capsid protein L1 mRNAs: SD3632 and SA5639. These suppressed in mitotic cells. This study showed that serine/arginine-rich 30c (SRp30c), also named SFRS9, activated both SA5639 induced production of mRNA. Activation HPV-16 mRNA splicing SRp30c required an intact arginine/serine-repeat (RS) domain SRp30c. In addition to this effect, could enhance indirectly inhibiting early 3'-splice site SA3358,...

Abstract Both of the uplift Qinghai-Tibet Plateau (QTP) and development East Asian monsoon system (EAMS) could have comprehensively impacted formation evolution Arid Central Asia (ACA). To understand how desert plants endemic to ACA responded these two factors, we profiled historical population dynamics distribution range shift a constructive shrub Reaumuria soongarica (Tamaricaceae) based on species wide investigation sequence variation chloroplast DNA nuclear ribosomal ITS. Phylogenetic...

An overmoded rectangularly corrugated relativistic surface wave oscillator is designed and theoretically analyzed to produce the high power terahertz radiation with a TM01 mode. The design fully verified optimized by 2.5D particle-in-cell simulations. A obtained output of 285 MW at frequency 0.148 THz conversion efficiency 20% when beam voltage about 400 kV, current 3.8 kA, magnetic field 6 T.

A method on electromagnetic mode analysis in overmoded structure terahertz source is studied this paper. This based Fourier-Bessel series and the particle-in-cell simulation. The result of shows that there are TM02 TM03 modes present waveguide motivated by change discontinuity. content keeps stable when device starts to work. magnetic field voltage beam do not some extent. parameters diode affect significantly.

Abstract Plasmon‐free surface‐enhanced Raman spectroscopy (SERS) assisted by charge‐transfer (CT) resonance in semiconductors has drawn considerable attention the past decades due to extraordinary advantages chemical stability and homogeneity. Unfortunately, weak confinement of excitation light semiconductor nanostructures 2D materials, either their limited refractive indexes or atomic thickness, results enhancement nonmetallic SERS substrates significantly lower than noble ones. Here a...

Klystronlike relativistic backward wave oscillator (RBWO) can produce microwave power exceeding 5 GW with a high efficiency larger than 40%. In the experiment of klystronlike RBWO, for about 1 MV peak diode voltages, increasing magnetic field from 1.43 to 1.89 T slowed impedance collapse until it was suppressed completely. The introduction stainless steel obstructing ring aggravated collapse, whereas replacing flat provided more stable variation during pulse duration. These collapses did not...

The apparition of adaptive immunity in Gnathostomata correlates with the expansion E-protein family to encompass E2-2, HEB and E2A. Within family, E2-2 are more closely evolutionarily related but their concerted action hematopoiesis remains be explored. Here we show that combined disruption results failure express early lymphoid program CLPs a near complete block B-cell development. In thymus, ETPs were reduced T-cell development perturbed, resulting CD4 T- increased γδ numbers. contrast,...

Abstract Monolayer transition metal dichalcogenides (ML‐TMDCs) possess degenerate levels with antiparallel spins in K and ′ valleys, providing the intrinsic valley polarization, which attracts great interest for potential applications on quantum information technology on‐chip nanophotonics. Unfortunately, it is difficult to distinguish degree of polarization (DoP) near room temperature due intensive phonon‐assisted intervalley scattering long‐range electron‐hole exchange interaction...

Hypoparathyroidism, deafness, and renal dysplasia (HDR) syndrome is an infrequent autosomal dominant genetic disorder caused by haploinsufficiency of the GATA binding protein 3 ( GATA3 ) gene. In this report, we present a case study 6-year-old female patient manifesting seizures, tetany, hypoparathyroidism, sensorineural hearing loss. A heterozygous variant, c.1050 + 2T>C, in gene was discovered testing. Moreover, minigene splicing experiment revealed that aforementioned variation...