A5101450453- Insect symbiosis and bacterial influences
- Trypanosoma species research and implications
- RNA Research and Splicing
- MicroRNA in disease regulation
- Biological and pharmacological studies of plants
- Plant Gene Expression Analysis
- Studies on Chitinases and Chitosanases
- Cancer-related molecular mechanisms research
- CRISPR and Genetic Engineering
- GABA and Rice Research
- Plant Molecular Biology Research
Yale University
2018-2021
Kunming Institute of Botany
2019-2021
Chinese Academy of Sciences
2021
Yale Cancer Center
2018
Abstract Measuring multiple omics profiles from the same single cell opens up opportunity to decode molecular regulation that underlies intercellular heterogeneity in development and disease. Here, we present co-sequencing of microRNAs mRNAs using a half-cell genomics approach. This method demonstrates good robustness (~95% success rate) reproducibility ( R 2 = 0.93 for both mRNAs), yielding paired microRNA mRNA profiles, which can independently validate. By linking level expression...
The Dendrobium plants (members of the Orchidaceae family) are used as traditional Chinese medicinal herbs. Bibenzyl, one active compounds in officinale, occurs low amounts among different tissues. However, market demands require a higher content thes to meet threshold for drug production. There is, therefore, an immediate need dissect physiological and molecular mechanisms underlying how bibenzyl biosynthesized D. officinale In this study, accumulation erianin gigantol tissues were studied...
Tsetse flies are vectors of parasitic African trypanosomes, the etiological agents human and animal trypanosomoses. Current disease control methods include fly-repelling pesticides, fly trapping, chemotherapeutic treatment infected people animals. Inhibiting tsetse’s ability to transmit trypanosomes by strengthening fly’s natural barriers can serve as an alternative approach reduce disease. The peritrophic matrix (PM) is a chitinous proteinaceous barrier that lines insect midgut serves...
ABSTRACT Co-measurement of multiple omic profiles from the same single cells opens up opportunity to decode molecular regulation that underlie intercellular heterogeneity in development and disease. Here, we present co-sequencing microRNAs mRNAs using a half-cell genomics approach. This method demonstrates good robustness (~95% success rate) reproducibility (R 2 =0.93 for both miRNAs mRNAs), yields paired miRNA mRNA could be independently validated. Linking level expression predicted target...
Abstract Background: Dendrobium plants are well known for their uses in traditional Chinese herbal medicine. Bibenzyl compounds the main active officinale. However, physiological and molecular basis biosynthesis of bibenzyl remains underexplored. Results: In this study, accumulation erianin gigantol were studied as representative bibenzyl. Their presence plant tissues investigated. Our results show that root contained highest content (erianin gigantol). Based on pre-experimental result...
Abstract Tsetse flies are vectors of parasitic African trypanosomes ( Trypanosoma spp.). Current disease control methods include fly-repelling pesticides, trapping flies, and chemotherapeutic treatment infected people. Inhibiting tsetse’s ability to transmit by strengthening the fly’s natural barriers can serve as an alternative approach reduce disease. The peritrophic matrix (PM) is a chitinous proteinaceous barrier that lines midgut. It protects epithelial cells from gut lumen content such...