A5008302971- Viral gastroenteritis research and epidemiology
- Immune Cell Function and Interaction
- Recycling and Waste Management Techniques
- Virus-based gene therapy research
- Immune cells in cancer
- Animal Virus Infections Studies
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Electric Vehicles and Infrastructure
- Extraction and Separation Processes
- Diabetes and associated disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- CAR-T cell therapy research
- Energy and Environment Impacts
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Mosquito-borne diseases and control
- Dengue and Mosquito Control Research
- Sustainable Supply Chain Management
- Lymphoma Diagnosis and Treatment
- Hepatitis B Virus Studies
- Cancer Research and Treatments
- S100 Proteins and Annexins
- Cancer Immunotherapy and Biomarkers
Jilin Medical University
2015-2025
China University of Geosciences (Beijing)
2022-2024
Jilin University
2015-2020
First Bethune Hospital of Jilin University
2016-2020
IL-17 is a proinflammatory cytokine produced by various immune cells. Polymorphonuclear neutrophils (PMNs) are the first line of defense in bacterial infection and express surface Toll-like receptor 9 (sTLR9). To study relationship sTLR9 PMNs during infection, we infected mice with E. coli intraperitoneally to establish septic peritonitis model for studying response peritoneal cavity. We found that some “giant cells” were massively accumulated cavity fatal induced . Kinetically, CD11b +...
A previous study found that an AAAG-rich Oligodeoxynucleotide (ODN), designated as MS19, could lessen the acute lung inflammatory injury (ALII) in mice infected by influenza viruses. Bioinformatics analysis MS19 is consensus with binding site of interferon regulatory factor 5 (IRF5) elements pro-inflammatory genes. This established a septic peritonitis model Institute Cancer Research (ICR) Escherichia coli (E. coli), and prolonged survival down-regulated expression inducible nitric oxide...
Monitoring the assembly and disassembly of virus-like particles (VLPs) is important in developing effective VLP-based vaccines. We tried to establish a simple rapid method evaluate status VLP using fluorescence spectroscopic analysis (FSA) while vaccine against porcine circovirus type 2b (PCV2b). synthesized gene coding for PCV2b capsid protein (CP). The CP was expressed <i>Escherichia coli</i> soluble form, dialyzed into three different buffers, assembled VLPs. immunogenicity...
Abstract The success of using immune checkpoint inhibitors to treat cancers implies that inhibiting an immunosuppressive cytokine, such as TGF-β2, could be a strategy develop novel adjuvants for microbial vaccines. To nucleic acid based TGF-β2 inhibitors, we designed three antisense oligonucleotides, designated TIO1, TIO2, and TIO3, targeting the conserve regions identical in human mouse mRNA 3′-untranslated region. In cultured cells, TIO3 TIO1 significantly reduced expression protein...
Natural killer group 2 member D (NKG2D) ligands (NKG2DLs) on tumor cells engage NKG2D and mediate killing by NKG2D+ immune cells. However, with high levels of NKG2DLs are still malignant proliferate rapidly. We investigated the reason for NKG2DL-expressing cell progression. Tumor in mice were assessed their NKG2DL expression, ability to attract cells, tumorigenicity, mTOR, signal transducer activator transcription 3 (STAT3) signaling activation. Antibody blockade was used determine effect...
Antibody responses to vaccines can be influenced by various behavioral and psychosocial factors. Few reports exist on the impact of fighting antibody response vaccines. This study unexpectedly found that could significantly enhance production in male mice immunized with hepatitis B virus (HBV) To confirm finding, a mouse-fighting model was established which it observed only intense fighting, not mild enhanced HBV surface antigen mice, frequency active attacks during showed no obvious...
// Li Hua 1 , Mingli Fang 2 Boqi Dong Sheng Guo Cuiyun Cui Jiwei Liu Yun Yao Yue Xiao Xin Yunjia Ren Xiuping Meng Xu Hao Peiyan Zhao Yilan Song Liying Wang Yongli Yu Department of Immunology, College Basic Medical Sciences, Norman Bethune Health Science Center, Jilin University, Changchun, 130021, China Molecular Biology, Correspondence to: Wang, email: wlying@jlu.edu.cn Yu, ylyu@jlu.edu.cn Keywords: NKG2DL, allogeneic tumors, early stage, NK cells, NKG2D + cells Received: October 12,...
Electric vehicles (EVs) are developing rapidly in China, but domestic power battery recycling remains low, partly due to neglect by consumers. We construct a tripartite evolutionary game model comprising the government, consumers and EV manufacturers. The results show that when initial willingness of three parties recycle batteries is not strong, government takes lead drives participation manufacturers When have medium/high levels willingness, chooses nonregulated strategy. Simulations...