About
Contact & Profiles
A5060473003
Research Areas
- Biochemical and Molecular Research
- Lysosomal Storage Disorders Research
- Trypanosoma species research and implications
University of Würzburg
2021
The dense variant surface glycoprotein (VSG) coat of African trypanosomes represents the primary host-pathogen interface. Antigenic variation prevents clearing pathogen by employing a large repertoire antigenically distinct VSG genes, thus neutralizing host's antibody response. To explore epitope space VSGs, we generate anti-VSG nanobodies and combine high-resolution structural analysis VSG-nanobody complexes with binding assays on living cells, revealing that these camelid antibodies bind...
10.1016/j.celrep.2021.109923
article
EN
cc-by-nc-nd
Cell Reports
2021-11-01
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